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memo - Magazine of European Medical Oncology OnlineFirst articles

29.10.2020 | review

Fertility preservation in women with endometrial cancer

Fertility preservation should only be offered to patients with endometrial cancer stage Ia grade 1 (G1), who present without myometrial invasion or where the cancer has invaded less than 50% of the myometrium, with no evidence of pathological …

Autoren:
MD Helena Bralo, MD Maria Roethlisberger, MD Assoc. Prof. Kazem Nouri

27.10.2020 | short review Open Access

Prevalence of comorbidities in elderly cancer patients

Comorbidity is common among cancer patients and increases with age. Comorbid conditions potentially affect treatment, therapy outcomes, and survival of people with cancer. This short review aims at presenting the prevalence of comorbidities, to …

Autoren:
MD Alfa Wenkstetten-Holub, MD Maria Fangmeyer-Binder, MD Prof. Peter Fasching

21.10.2020 | short review

Tackling DNA damage repair mechanisms—a promising molecular informed therapeutic approach in pancreatic ductal adenocarcinoma

Molecular targeted therapies in pancreatic ductal adenocarcinoma (PDAC) lag behind treatment options in other tumor entities. The POLO trial has provided promising preliminary data for targeting gBRCA in PDAC by the poly(ADP-ribose) polymerase …

Autor:
Bernhard Doleschal

20.10.2020 | short review Open Access

Cytoreductive surgery and HIPEC in colorectal cancer—did we get hold of the wrong end of the stick?

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are a multimodal treatment approach combining surgical interventions of varying extent with administration of heated cytostatic drugs flushed through the abdominal …

Autoren:
Can Yurttas, Oliver M. Fisher, Delia Cortés-Guiral, Sebastian P. Haen, Ingmar Königsrainer, Alfred Königsrainer, Stefan Beckert, Winston Liauw, Markus W. Löffler

13.10.2020 | original report

WNT3 and LEF1 as markers for diagnosis and survival prediction in chronic lymphocytic leukemia patients

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy characterized by clonal expansion and accumulation of mature B‑lymphocytes in peripheral blood, bone marrow, and secondary lymphoid tissues [ 1 ]. CLL is highly heterogeneous where some …

Autoren:
Manal Atef, MD/PhD Layla M. Saleh, Noha Eisa, Sameh Shamaa

30.09.2020 | case report Open Access

A case report on the long-term survival of a patient with HER2-positive metastatic gastric adenocarcinoma and a short review of the current literature

The prognosis of patients with metastatic gastroesophageal cancer remains poor despite numerous promising clinical trials, and the clinical benefit of systemic therapies is under critical review. This case report of a patient with human epidermal …

Autoren:
MD Hannah Christina Puhr, MD PhD Aysegül Ilhan-Mutlu

21.09.2020 | short review

Autologous stem cell transplantation in light-chain amyloidosis

Treatment of patients with light-chain amyloidosis (AL amyloidosis) has changed over the last 20 years, and early mortality rates have decreased with prolongation of survival. However, many patients are not cured with conventional therapy.

Autor:
PD Dr. Alexandra Böhm

18.09.2020 | short review Open Access

Ovarian transposition

Cytotoxic chemotherapy regimens and radiotherapy can lead to acute ovarian failure, premature ovarian insufficiency and menopause. Fertility preservation options before radiotherapy include ovarian transposition, where one or both ovaries are …

Autoren:
Elisabeth Reiser, Bettina Böttcher, Danijela Minasch, Julian Mangesius, Bettina Toth

18.09.2020 | short review Open Access

Do we still need CRS and HIPEC in colorectal cancer in times of modern chemotherapy and immunotherapy?

Peritoneal carcinomatosis from colorectal cancer is associated with a poor prognosis and is usually treated with systemic chemotherapy and immunotherapy alone. In patients with isolated peritoneal carcinomatosis (PC) without nonperitoneal …

Autoren:
Dr. Elisabeth Gasser, PD Dr. Pamela Kogler, Dr. Andreas Lorenz, PD Dr. Reinhold Kafka-Ritsch, Univ. Prof. Dr. Dietmar Öfner, Assoc. Professor PD Dr. med. univ. Alexander Perathoner

28.08.2020 | short review

Transoral robotic surgery in head and neck cancer

Robotic surgery in the field of head and neck cancer was initiated at the beginning of this century. In the last decade, transoral robotic surgery (TORS) had to prove its oncological equivalence to standardised conservative treatment regimens like …

Autoren:
Andreas Strobl, Maximilian Hartl, Martin Burian

14.08.2020 | short review Open Access

Clinical characteristics and treatment of delirium in palliative care settings

Delirium is commonly seen in palliative care. It usually develops over a short period of time and is characterized by a disturbance of attention and awareness. As delirium is associated with increased mortality, prevention and early identification …

Autoren:
MD Filipe Portela Millinger, MD Matthäus Fellinger

29.07.2020 | short review Open Access

Sarcopenia in cancer—a focus on elderly cancer patients

Geriatric assessments, nutritional counseling and monitoring of muscle health before and during therapy are of high clinical significance in the management of elderly cancer patients. Criteria, data and cut-offs characterizing cancer-related …

Autoren:
PhD Dr. Maximilian Marhold, MSc Thais Topakian, PhD Dr. Matthias Unseld

13.07.2020 | short review Open Access

Monoclonal gammopathy of undetermined significance (MGUS): where is the hidden danger? Definition and work-up

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant hematological condition arising from B‑cells, characterized by the presence of monoclonal immunoglobulin production, also known as paraprotein. It is found in up to 3% of …

Autoren:
Georg Jeryczynski, Maria-Theresa Krauth

13.07.2020 | short review

Patient selection for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in colorectal cancer

Colorectal peritoneal metastasis (pmCRC) occurs in up to 15% of patients with colorectal cancer (CRC) [ 1 – 3 ]. In Germany in 2018 approximately 55% of hyperthermic intraperitoneal chemotherapy (HIPEC) procedures were performed for peritoneal …

Autoren:
Philipp Horvath, Ingmar Königsrainer

23.06.2020 | short review Open Access

Future perspectives of fertility preservation in women

Fertility preservation in women has become well established over the last two decades. Nevertheless, options for cancer survivors need to be improved to regain ovarian functioning, ideally leading to pregnancy and live birth. Techniques to protect …

Autoren:
MD, MA Bettina Böttcher, MD Katharina Winkler-Crepaz

09.06.2020 | short review Open Access

Homologous recombination deficiency in breast cancer

BRCA mutation-related DNA repair deficiencies increase the individual sensitivity to DNA-targeting agents. Therefore, the patient’s BRCA mutational status is evaluated in clinical practice as a predictive marker in response to platinum salts and …

Autoren:
MD BA Dr. Thomas Bartl, MD PhD Alex Farr

09.06.2020 | review Open Access

Geriatric oncology: questions, answers and guidelines

Raising awareness of the necessity to adapt cancer therapy to the individual needs and resources of elderly cancer patients is the mission for geriatric oncology in the 21st century. Since its beginnings around the turn of the millennium [ 1 ] …

Autoren:
MD, PhD Matthias Unseld, MD Christine Marosi

04.06.2020 | short review

Particle therapy in head and neck cancer—expanding therapeutic options

The management of head and neck tumors is challenging and requires a multidisciplinary approach. Besides the common histology of squamous cell cancer, other histologies like adenoid cystic carcinoma, mucosal melanoma, and adenocarcinoma are often …

Autor:
MD, PhD Petra Georg

20.05.2020 | short review Open Access

Fertility preservation procedures in girls, adolescents and women

Fertility preservation has become an integral part of standard treatment for young patients with planned gonadotoxic therapy. The decision-making process is an interdisciplinary challenge to both oncologists and radiotherapists involved in the …

Autoren:
MA Dr. Bettina Böttcher, Dr. Maren Goeckenjan

14.05.2020 | short review Open Access

Nutritional management during treatment for head and neck cancer

Cancer patients are at risk of malnutrition due to disease progress and antitumor therapy. The risk for patients with head and neck cancer is even higher due to the location of their tumor. The development of difficulties in chewing and dysphagia …

Autor:
MSc Christina Wagner