Hepatoid adenocarcinomas (HAC), first described in 1985 by Ishikura et al. [ 1 ], are a rare type of extrahepatic alpha-fetoprotein secreting tumor with hepatocellular carcinoma (HCC) like morphology. Since that time, only 33 cases of HAC of the …
Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells driven by mutations in the mitogen-activated protein kinase (MAPK) pathway. It can present as single or multisystem LCH. It occurs in 0.5–5.4 per million …
Autoren:
Dr. Ilson Sepúlveda, Ignacio Mendoza, Romina Novoa, Geraldine Ayres, Nadia Inostroza, J Patricio Ulloa, Francisco Rivas-Rodriguez
Advanced stage prostate cancer is frequently treated with androgen receptor antagonists. Improvement in patients’ survival has been achieved with the anti-androgen enzalutamide. However, there may be an increasing number of point mutations of the …
The benefits of screening programs are highly dependent on risk group definition. This is especially true for lung cancer screening. Results from the National Lung Cancer Screening Trial (NLST) and the NELSON trial (Dutch/Belgian randomised lung …
Non-small cell lung cancer (NSCLC) accounts for about 85% of all diagnosed lung cancers and at initial diagnosis nearly 70% of all patients suffer from locally advanced or metastatic disease [ 1 , 2 ]. Accordingly, most patients require systemic …
Autoren:
Diego Kauffmann-Guerrero, Andreas Schindler, Amanda Tufman, Zulfiya Syunyaeva, Thomas Pfluger, Rudolf Maria Huber, Frank Berger, Kathrin Kahnert
Correction to: memo 2019 https://doi.org/10.1007/s12254-019-0487-4 The original version of this article unfortunately contained a mistake.The spelling of the last author’s name is “Prerna Mewawalla”.The original article has been … …
Autoren:
MD Abhishek Chaturvedi, MD Muhammad Salman Faisal, MD Ahmed Khattab, MD Joan Devine, MD Dr. Prerna Mewawalla
In the field of thrombosis and hemostasis the focus was laid on the prophylaxis and treatment of venous thromboembolism in patients with active cancer during this years’ meeting of the American Society of Hematology (ASH) in San Diego. The …
How does lung cancer treatment benefit from the NELSON trial
With the release of the survival results from the NELSON lung cancer screening trial there is now additional evidence that low-dose computed tomography (LDCT) screening leads to a reduction of lung cancer mortality in high-risk individuals. These …
Immuno-oncology and in particular checkpoint inhibitor (CPI) treatment has become a novel promising cancer therapy strategy in recent years. However, still a minority of patients respond to checkpoint blockade. Primary and secondary resistance to …
Implementation of lung cancer screening is a challenge for radiology. The present short review summarizes major requirements which are needed to ensure high rates of diagnostic accuracy and appropriate protocols for follow-up and invasive work-up.
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive inflammation and immune activation. The syndrome can be triggered by multiple events that disrupt immune homeostasis, including infection, autoimmune diseases, and lymphoma.
Autoren:
MD Abhishek Chaturvedi, MD Muhammad Salman Faisal, MD Ahmed Khattab, MD Joan Devine, MD Dr. Prerna Mewawalla
The approval of imatinib for the treatment of patients with gastrointestinal stromal tumor has (GIST) revolutionized the treatment in the adjuvant setting and metastatic disease. Imatinib is an inhibitor of the receptor tyrosine kinases KIT and …
Autoren:
Andreas Seeber, Alexander Perathoner, Florian Kocher
The most common driver mutation in non-small cell lung cancer (NSCLC) is found within the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). It commonly affects younger, female, and non-smoking patients. To date, there are five …
Reasons for high smoking prevalence in Europe compared to Australia and North America are low prices of tobacco adjusted for purchasing power and poor smoke-free legislation and enforcement in Central and Eastern Europe. High rates of passive …
Venous thrombosis and pulmonary embolism are common complications in patients with active cancer. For many years low molecular weight heparins (LMWH) have been the preferred treatment option for cancer patients, because of their superiority over …
Autoren:
Johannes B. Jaeger, Thomas Jaeger, Ass. Prof. Priv. Doz. Dr. Clemens Feistritzer
Next-generation sequencing allows the simultaneous interrogation of a large number of genomic targets and is therefore highly suitable for situations, in which mutations in many different genes may have a clinical impact. This short educational …
Ovarian cancer (OC) is the foremost lethal gynaecologic malignancy and among the top five deadliest cancers in women. Current treatment comprises a combination therapy of surgery, platinum-based chemotherapy and anti-vascular endothelial growth …
Being the most commonly diagnosed cancer in women, breast cancer is the second leading cause of cancer deaths among women in the United States [ 1 ]. With an incidence exceeding 20%, metastatic cutaneous lesions are more often found in women with …
Autoren:
MD Ahmed A. M. Abdelhafeez, MD Wael Ibrahim, MD Wessam Elsherief