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memo - Magazine of European Medical Oncology OnlineFirst articles

13.01.2021 | short review Open Access

ASCO 2020 non-small lung cancer (NSCLC) personal highlights

In this article we summarize our personal non-small cell lung cancer (NSCLC) highlights of the virtual ASCO 2020 meeting, covering developments in early and advanced-stage NSCLC. Until recently early stage NSCLC patients were treated independently …

Autoren:
MD Lena Horvath, MD, PhD Andreas Pircher

06.01.2021 | short review Open Access

Monoclonal gammopathy of renal significance

A short clinical approach

Monoclonal gammopathy of renal significance (MGRS) encompasses a group of kidney disorders in which a monoclonal immunoglobulin secreted by a B cell or plasma cell clone causes renal damage, without meeting hematological criteria for malignancy.

Autoren:
MD Thomas Reiter, MD Maja Nackenhorst

23.12.2020 | original report

Effect of the ABO blood groups on the development, clinical features and survival of multiple myeloma

Multiple myeloma (MM) is a cytogenetically heterogeneous and incurable plasma cell disease characterized by clonal proliferation of malignant plasma cells [ 1 ]. It accounts for approximately 10% of all hematological malignancies [ 2 ]. MM is …

Autoren:
M.D Mesut Göçer, Erdal Kurtoğlu

11.12.2020 | short review Open Access

Genitourinary cancers—best of ASCO 2020

The aim of this short review is to summarize “clinical practice changing” abstracts about genitourinary cancers from this year’s ASCO Annual Meeting. The phase 3 JAVELIN Bladder 100 trial showed astonishing overall survival (OS) data up to 22 …

Autoren:
MD, PhD Renate Pichler, MD Gennadi Tulchiner, MD Jasmin Bektic

03.12.2020 | short review Open Access

Pharmacokinetic considerations in geriatric cancer patients

Pharmacological anticancer therapy in elderly people has to account for pharmacokinetic aspects in view of age-related changes in organ function and disease-related alterations. Age-related changes in organ function might still be physiological …

Autor:
Martin Hohenegger

02.12.2020 | original report

The emerging role of NOTCH target genes in Egyptian childhood acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is a malignant disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells, resulting in a marked decrease in normal blood cell production [ 1 ]. ALL …

Autoren:
Mona Reyad, Sherin Abdel-Aziz, Layla M. Saleh, Samah El-Ghlban, Ibrahim El Tantawy El Sayed, Hasan Abdel-ghaffar

24.11.2020 | short review

Physical activity and exercise in cancer patients with bone metastases

Physical activity and exercise can have numerous positive effects on various disease- and therapy-related symptoms across the continuum of cancer disease. These include an improvement in quality of life, physical function, aerobic fitness, muscle …

Autor:
MSc Dr. Winfried Habelsberger

27.10.2020 | short review Open Access

Prevalence of comorbidities in elderly cancer patients

Comorbidity is common among cancer patients and increases with age. Comorbid conditions potentially affect treatment, therapy outcomes, and survival of people with cancer. This short review aims at presenting the prevalence of comorbidities, to …

Autoren:
MD Alfa Wenkstetten-Holub, MD Maria Fangmeyer-Binder, MD Prof. Peter Fasching

13.10.2020 | original report

WNT3 and LEF1 as markers for diagnosis and survival prediction in chronic lymphocytic leukemia patients

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy characterized by clonal expansion and accumulation of mature B‑lymphocytes in peripheral blood, bone marrow, and secondary lymphoid tissues [ 1 ]. CLL is highly heterogeneous where some …

Autoren:
Manal Atef, MD/PhD Layla M. Saleh, Noha Eisa, Sameh Shamaa

21.09.2020 | short review

Autologous stem cell transplantation in light-chain amyloidosis

Treatment of patients with light-chain amyloidosis (AL amyloidosis) has changed over the last 20 years, and early mortality rates have decreased with prolongation of survival. However, many patients are not cured with conventional therapy.

Autor:
PD Dr. Alexandra Böhm

14.08.2020 | short review Open Access

Clinical characteristics and treatment of delirium in palliative care settings

Delirium is commonly seen in palliative care. It usually develops over a short period of time and is characterized by a disturbance of attention and awareness. As delirium is associated with increased mortality, prevention and early identification …

Autoren:
MD Filipe Portela Millinger, MD Matthäus Fellinger

29.07.2020 | short review Open Access

Sarcopenia in cancer—a focus on elderly cancer patients

Geriatric assessments, nutritional counseling and monitoring of muscle health before and during therapy are of high clinical significance in the management of elderly cancer patients. Criteria, data and cut-offs characterizing cancer-related …

Autoren:
PhD Dr. Maximilian Marhold, MSc Thais Topakian, PhD Dr. Matthias Unseld

13.07.2020 | short review Open Access

Monoclonal gammopathy of undetermined significance (MGUS): where is the hidden danger? Definition and work-up

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant hematological condition arising from B‑cells, characterized by the presence of monoclonal immunoglobulin production, also known as paraprotein. It is found in up to 3% of …

Autoren:
Georg Jeryczynski, Maria-Theresa Krauth

09.06.2020 | review Open Access

Geriatric oncology: questions, answers and guidelines

Raising awareness of the necessity to adapt cancer therapy to the individual needs and resources of elderly cancer patients is the mission for geriatric oncology in the 21st century. Since its beginnings around the turn of the millennium [ 1 ] …

Autoren:
MD, PhD Matthias Unseld, MD Christine Marosi

13.03.2020 | short review Open Access

Obstipation and diarrhoea in palliative care—a pharmacist’s view

This article is a brief overview of drugs, which are of use in the treatment of constipation and diarrhoea in palliative care. Whereas most of the drugs mentioned are widely used and known, the aspect of gastrointestinal symptoms as side effect of …

Autor:
Marie-Bernadette Aretin