nach oben

Tipp

Influence of a moderate physical activity intervention on red cell deformability in patients suffering from chronic obstructive pulmonary disease (COPD)

verfasst von: Basit Ahmad, Dip Sport Sci, Nina Ferrari, PhD Sport Sci, Dr. med. Georgina Montiel, Prof. Dr. Wilhelm Bloch, Dr. med. Anke Raabe-Oetker, Nina Skrobala, Prof. Dr. Klara Brixius

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 13-14/2013

Einloggen, um Zugang zu erhalten

Summary

The present study investigates whether a moderate physical activity intervention may alter red cell deformability (RCD) of patients suffering from chronic obstructive pulmonary disease (COPD). Subjects (n = 10; age: 62 ± 4; body-mass index (BMI): 25.8 ± 7.5) performed a training regimen for 10 weeks. In the beginning of the study and after the training period, COPD patients underwent a WHO cycle ergometry test. Venous blood samples were taken before (T0), immediately after (T1) and 30 min after (T2) the intervention. RCD was measured with the laser-assisted optical rotational cell analyzer (LORCA). Significant improvements of the RCD were detected. The semi-maximal shear stress increased significantly. Acute exhaustion had no effect on RCD. Thus, the training period of 10 weeks influenced RCD.

Vorheriger Artikel Die Briefe Ernst Wilhelm Brückes an Rudolf Virchow aus den Jahren 1850–1857

Nächster Artikel Alexej Gerassimovitsch Polotebnov (1838–1907) – der Begründer der wissenschaftlichen Dermatologie in Russland

Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet. 1997;349(9063):1436–42. PubMedCrossRef

Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, Schmid V, Buist S. Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J. 2006;27(2):397–412. PubMedCrossRef

Gershon AS, Warner L, Cascagnette P, Victor JC, To T. Lifetime risk of developing chronic obstructive disease: a longitudinal population study. Lancet. 2011;378:991–6. PubMedCrossRef

Fletcher MJ, Upton J, Taylor-Fishwick J, Buist SA, Jenkins C, Hutton J, Barnes N, Van Der Molen T, Walsh JW, Jones P, Walker S. COPD uncovered: an international survey on the impact of chronic obstructive pulmonary disease [COPD] on a working age population. BMC Public Health. 2011;11:612–25. PubMedCrossRef

Meyer A, Baumann HJ. Bewegungstherapie bei COPD. Dtsch Z Sportmedv. 2007;10:351–6.

Nadeem A, Raj AG, Chabra SK. Effect of vitamin E supplementation with standard treatment on oxidant-antioxidant status in chronic obstructive pulmonary disease. Indian J Med Res. 2008;128:705–11. PubMed

Mannino DM, Martinez FJ. Lifetime risk of COPD: what will the future bring? Lancet. 2011;378:964–5. PubMedCrossRef

Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet. 2011;378:1015–26. PubMedCrossRef

Minetti M, Leto T, Malorni W. Radical generation and alterations of erythrocyte integrity as bioindicators of diagnostic or prognostic value in COPD? Antioxid Redox Signal. 2008;10(4):829–36. PubMedCrossRef

10.

Pietraforte D, Matarrese P, Strafece E, Gambardella L, Metere A, Scorza G, Leto TL, Malorni W, Minetti M. Two different pathways are involved in peroxynitrite-induced senescence and apoptosis of human erythrocytes. Free Radic Biol Med. 2007;42:202–14. PubMedCrossRef

11.

Barnes PJ, Shapiro SD, Pauwels RA. Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J. 2003;22:672–88. PubMedCrossRef

12.

Drost EM, Skwarski KM, Sauleda J, Soler N, Roca J, Agusti A, MacNee W. Oxidative stress and airway inflammation in severe exacerbations of COPD. Thorax. 2005;60:293–300. PubMedCrossRef

13.

Lucantoni G, Pietraforte D, Matarresse P, Gambardella L, Meter A, Paone G, Bianchi EL, Straface E. The red blood cell as a biosensor for monitoring oxidative imbalance in chronic obstructive pulmonary disease: an ex vivo and in vitro study. Antioxid Redox Signal. 2006;8:1172–82. CrossRef

14.

Berliner S, Rogowski O, Aharonov S, Mardi T, Tolshinsky T, Rozenblat M, Justo D, Deutsch V, Serov J, Shapira I, Zeltzer D. Erythrocyte adhesiveness/aggregation: a novel biomarker for the detection of low-grade internal inflammation and proven vascular disease. Am Heart J. 2005;149:260–7. PubMedCrossRef

15.

Rogowski O, Berliner S, Zeltser D, Serov J, Ben-Assayag E, Justo D, Rozenblat M, Kessler A, Deutsch V, Zakuth V, Shapira I. The erythrocytosense as a real-time biomarker to reveal the presence of enhanced red blood cell aggregability in atherothrombosis. Am J Ther. 2005;12:286–92. PubMedCrossRef

16.

Shin S, Ku YH, Ho JX, Kim YK, Suh JS, Singh M. Progressive impairment of erythrocyte deformability as indicator of microangiopathy in type 2 diabetes mellitus. Clin Hemorheol Microcirc. 2007;36:253–61. PubMed

17.

Chien S. Red cell deformability and its relevance to blood flow. Ann Rev Physiol. 1987;49:177–92. CrossRef

18.

Chien S. Shear dependence of effective cell volume as a determinant of blood viscosity. Science. 1970;168:977–8. PubMedCrossRef

19.

Mohandas N, Clark MR, Jacobs MS, Groner W, Shohet SB. Ektacytometric analysis of factors regulating red cell deformability. Blood Cells. 1980;6:329–34. PubMed

20.

Athanassiou GA, Moutzouri AG, Gogos CA, Skouletis AT. Red blood cell deformability in patients with human immunodeficiency virus infection. Eur J Clin Microbiol Infect Dis. 2010;29(7):845–9. PubMedCrossRef

21.

Cicco G, Pirelli A. Red blood cell (RBC) deformability, RBC aggregability and tissue oxygenation in hypertension. Clin Hemorheol Microcirc. 1999;21:169–77. PubMed

22.

Wen ZG. Observation on red cell deformability in patients with cor pulmonale. Zhonghua Jie He He Hu Xi Za Zhi. 1992;15(5):279–81, 318–9. PubMed

23.

Muravyov AV, Draygin SV, Eremin NN, Muravyov AA. The microrheological behavior of young and old red blood cells in athletes. Clin Hemorheol Microcirc. 2002;26:183–8. PubMed

24.

Cakir-Atabek H, Atsak P, Gunduz N, Bor-Kucukatay M. Effects of resistance training intensity on deformability and aggregation of red blood cells. Clin Hemorheol Microcirc. 2009;41:251–61. PubMed

25.

Lacasse Y, Brosseau S, Milne S, Martin E, Wong E, Guayatt G, Goldstein R, White J. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2006;4:CD003793. Review.

26.

Niederman M, Clemente P, Fein A, Feinsilver S, Robinson D, Ilowite J, Bernstein M. Benefits of a multidisciplinary pulmonary rehabilitation program. Improvements are independent of lung function. Chest. 1991;99:798–804. PubMedCrossRef

27.

Maltais F, Simard AA, Simard C, Jobin J, Desgagnes P, Leblanc P. Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD. Am J Respir Crit Care Med. 1996;153:288–93. PubMedCrossRef

28.

O’Shea SD, Taylor NF, Paratz J. Peripheral muscle strength training in COPD: a systematic review. Chest. 2004;126:903–14. PubMedCrossRef

29.

Griffiths TL, Burr ML, Campbell IA, Lewis-Jenkins V, Mullins J, Shiels K, Turner-Lawlor PJ, Payne N, Newcombe RG, Ionescu A, Thomas J, Tunbridge J. Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomized control trial. Lancet. 2000;355:362–8. PubMedCrossRef

30.

Salman G, Mosier M, Beasley B, Calkins D. Rehabilitation for patients with chronic obstructive pulmonary disease: meta-analysis of randomized controlled trials. J Gen Intern Med. 2003;18:213–21. PubMedCrossRef

31.

Ko FWS, Hui DSC. The lower the body weight for COPD patients, the more effective is pulmonary rehabilitation? Am Pol Sci Rev. 2011;16:187–9.

32.

Baskurt OK, Hardeman MR, Uyuklu M, Ulker P, Cengiz M, Nemeth N, Shin S, Alexy T, Meiselman HJ. Parameterization of red blood cell elongation index—shear stress curves obtained by ektacytometry. Scand J Clin Lab Investig. 2009;69:777–88. CrossRef

33.

Decramer M. Effects of rehabilitation and muscle training on quality of life in COPD patients. Eur Respir Rev. 1997;7:92–5.

34.

Bernard S, LeBlanc P, Whittom F, Carrier G, Jobin J, Belleau R, Maltais F. Peripheral muscle weakness in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;158:629–34. PubMedCrossRef

35.

Lacasse Y, Wong E, Guyatt GH, King D, Cook DJ, Goldstein RS. Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease. Lancet. 1996;348:1115–9. PubMedCrossRef

36.

O’Donnell DE, McGuire M, Samis L, Webb KA. General exercise training improves ventilatory and peripheral muscle strength and endurance in chronic airflow limitation. Am J Respir Crit Care Med. 1998;157:1489–97. PubMedCrossRef

37.

Gosselink R, Trooster T, Decramer M. Peripheral muscle weakness contributes to exercise limitation in COPD. Am J Respir Crit Care Med. 1996;153:976–80. PubMedCrossRef

38.

Hamilton AL, Killian KJ, Summers E, Jones NL. Muscle strength, symptom intensity, and exercise capacity in patients with cardio-respiratory disorders. Am J Respir Crit Care Med. 1995;152:2021–31. PubMedCrossRef

39.

Serres I, Gautier V, Varray A, Prefaut C. Impaired skeletal muscle endurance related to physical inactivity and altered lung function in COPD patients. Chest. 1998;113:900–5. PubMedCrossRef

40.

Jakobsson P, Jorfeldt L, Brundin A. Skeletal muscle metabolites and fibre types in patients with advanced chronic obstructive pulmonary disease (COPD) with and chronic respiratory failure. Eur Respir J. 1990;3:192–6. PubMed

41.

Spruit MA, Gosselink R, Troosters T, De Paepe K, Decramer M. Resistance versus endurance training in patients with COPD and peripheral muscle weakness. Eur Respir J. 2002;19:1072–8. PubMedCrossRef

42.

Gallefoss F, Bakke PS. Cost-benefit and cost-effectiveness analysis of self-management in patients with COPD—a 1-year follow-up randomized, controlled trial. Respir Med. 2002;96:330–5. CrossRef

43.

Rossi G, Florini F, Romagnoli M, Bellantone T, Lucic S, Lugli D, Clini E. Length and clinical effectiveness of pulmonary rehabilitation in outpatients with chronic airway obstruction. Chest. 2005;127:105–9. PubMedCrossRef

44.

Whittom F, Jobin J, Simard PM, Leblanc P, Simard C, Bernard S, Belleau R, Maltais F. Histochemical and morphological characteristics of vastus lateralis muscle in patients with chronic obstructive pulmonary disease. Med Sci Sports Exerc. 1998;30:1467–74. PubMedCrossRef

45.

Ricciardolo O, Di Stefano A, Sabatini F, Folkerts G. Reactive nitrogen species in the respiratory tract. Eur J Pharmacol. 2006;533:240–52. PubMedCrossRef

46.

De Castro J, Hernández-Hernández A, Rodrígzuez MC, Sardina JL, Llanillo M, Sánchez-Yagȕe J. Comparison of changes in erythrocyte and platelet phospholipid and fatty acid composition and protein oxidation in chronic obstructive pulmonary disease and asthma. Platelets. 2007;18(1):43–51. PubMedCrossRef

47.

Santini MT, Cipri A, Peverini M, Straface E, Malorni W. Ultrastructural alterations in erythrocytes from COPD patients. Haemostasis. 1997;27:201–10. PubMed

48.

Cook MK. Red cell macrocytosis and COPD. Br J Haematol. 1993;83:174–6. PubMedCrossRef

49.

Tsantes A, Papadhimitriou SI, Tassiopoulos ST, Bonovas S, Paterakis G, Meletis I, Loukopoulos D. Red cell macrocytosis in hypoxemic patients with chronic obstructive pulmonary disease. Resp Med. 2004;98(11):1117–23. CrossRef

50.

Temiz A, Baskurt OK, Pekcetin C, Kandemir F, Güre A. Leukocyte activation, oxidant stress and red blood cell properties after acute, exhausting exercise in rats. Clin Hemorheol Microcirc. 2000;22:253–9. PubMed

51.

Yalcin O, Bor-Kucukatay M, Sentürk UK, Baskurt O. Effects of swimming exercise on red blood cell rheology in trained and untrained rats. J Appl Physiol. 2000;88:2074–80. PubMed

52.

Baskurt OK, Farley RA, Meiselmann HJ. Erythrocyte aggregation tendency and cellular properties in horse, human and rat: a comparative study. Am J Physiol. 1997;273(6):H2604–12. PubMed

53.

Hawkey CM, Bennet PM, Gascoyne SC, Hart MG, Kirkwood JK. Erythrocyte size, number and hemoglobin content in vertebrates. Br J Haematol. 1991;77(3):392–7. PubMedCrossRef

54.

Sentürk UK, Gündüz F, Kuru O, Kocer G, Ozkaya YG, Yesilkaya A, Bor-Kücükatay M, Uyüklu M, Yalcin O, Baskurt OK. Exercise-induced oxidative stress leads hemolysis in sedentary but not trained humans. J Appl Physiol. 2005;99(4):1434–41.

55.

Smith JA. Exercise, training and red blood cell turnover. Sports Med. 1995;19:9–31. PubMedCrossRef

56.

Szygula Z. Erythrocytic system under the influence of physical exercise and training. Sports Med. 1990;10:181–97. PubMedCrossRef

57.

Weight LM, Byrne MJ, Jacobs P. Haemolytic effects of exercise. Clin Sci (Lond). 1991;81(2):147–52. PubMed

58.

Mika P, Spodaryk K, Cencora A, Mika A. Red cell deformability in patients with claudication after pain-free treadmill training. Clin J Sport Med. 2006;16:335–40. PubMedCrossRef

59.

Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol. 2003;284:1–12.

60.

Suhr F, Porten S, Hertrich T, Brixius K, Schmidt A, Platen P, Bloch W. Intensive exercise induces changes of endothelial nitric oxide synthase pattern in human erythrocytes. Nitric Oxide. 2009;20:95–103. PubMedCrossRef

61.

Simmonds MJ, Tripette J, Sabapathy S, Marshall-Gradisnik SM, Connes P. Cardiovascular dynamics during exercise are related to blood rheology. Clin Hemorheol Microcirc. 2011;49:231–41. PubMed

62.

Cabrales P. Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemia. Am J Physiol Heart Circ Physiol. 2007;293:H1206–15. PubMedCrossRef

Titel: Influence of a moderate physical activity intervention on red cell deformability in patients suffering from chronic obstructive pulmonary disease (COPD)
verfasst von: Basit Ahmad, Dip Sport Sci
Nina Ferrari, PhD Sport Sci
Dr. med. Georgina Montiel
Prof. Dr. Wilhelm Bloch
Dr. med. Anke Raabe-Oetker
Nina Skrobala
Prof. Dr. Klara Brixius
Publikationsdatum: 01.07.2013
Verlag: Springer Vienna
Erschienen in: Wiener Medizinische Wochenschrift / Ausgabe 13-14/2013
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI: https://doi.org/10.1007/s10354-013-0183-7

Springer Medizin Österreich

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Influence of a moderate physical activity intervention on red cell deformability in patients suffering from chronic obstructive pulmonary disease (COPD)

Summary

Springer Medizin Österreich

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 13-14/2013

Karl Alfons Portele, Pathologe und erster Direktor des Pathologisch-anatomischen Bundesmuseums in Wien

Alexej Gerassimovitsch Polotebnov (1838–1907) – der Begründer der wissenschaftlichen Dermatologie in Russland

200 Jahre Wiener Universitätspathologie

Trauer um Prof. Dr. J. H. Holzner – ein Leben für die Pathologie

Die Wiener Universitätspathologie – eine Chronologie der letzten 200 Jahre

Lorenz Biermayer und die Entstehung der Pathologisch-anatomischen Sammlung im Wiener Narrenturm