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13.07.2020 | short review

San Antonio Breast Cancer Symposium 2019: human epidermal growth factor receptor 2(HER2)-positive breast cancer and image-guided biopsy to detect pathologic complete response (pCR)

verfasst von: Clemens Dormann, M.D.

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 3/2020

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Summary

At the 2019 San Antonio Breast Cancer Symposium, new data on the management of heavily pretreated human epidermal growth factor receptor 2(HER2)-positive metastatic breast cancer were discussed. The phase 3 HER2CLIMB and the phase 2 DESTINY-Breast01 trials investigating tucatinib and trastuzumab deruxtecan, respectively, have met their primary endpoints.

In an early disease setting, four studies investigated whether image-guided biopsies could identify patients with a pathologic complete response (pCR) to neoadjuvant chemotherapy, thus allowing safe omission of surgery. As residual disease was missed in a significant number of cases, these trials could not confirm data from smaller previous studies.

Vorheriger Artikel Four lines of immunochemotherapy combinations in a young patient with an aggressive metastatic colorectal cancer

Nächster Artikel Treatment options in early triple-negative breast cancer

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Titel: San Antonio Breast Cancer Symposium 2019: human epidermal growth factor receptor 2(HER2)-positive breast cancer and image-guided biopsy to detect pathologic complete response (pCR)
verfasst von: Clemens Dormann, M.D.
Publikationsdatum: 13.07.2020
Verlag: Springer Vienna
Erschienen in: memo - Magazine of European Medical Oncology / Ausgabe 3/2020
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI: https://doi.org/10.1007/s12254-020-00632-x

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San Antonio Breast Cancer Symposium 2019: human epidermal growth factor receptor 2(HER2)-positive breast cancer and image-guided biopsy to detect pathologic complete response (pCR)

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New systemic treatment options in mycosis fungoides and Sézary syndrome

Creating the “new normal” post-Coronavirus world—web-communication replacing face-to-face interaction

Myeloid diseases—Chronic Myeloid Leukemia (CML)—report from ASH 2019 on new developments

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