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15.04.2020 | short review | Ausgabe 3/2020 Open Access

memo - Magazine of European Medical Oncology 3/2020

Neoadjuvant chemoradiotherapy in rectal cancer

Are there new drug combinations on the horizon?

Zeitschrift:
memo - Magazine of European Medical Oncology > Ausgabe 3/2020
Autoren:
MD, PhD Christoph Reinhold Arnold, MD Julian Mangesius, MD Robert Jäger, MD Ute Ganswindt
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Summary

Neoadjuvant chemoradiotherapy is a well-established standard treatment for locally advanced rectal cancer and has led to a remarkable improvement in local control. However, distant recurrences still pose a notable threat and local failure, albeit increasingly rare, can lead to unfavorable clinical situations. In this short review, we discuss three promising new strategies to improve rectal cancer treatment: total neoadjuvant therapy, short course radiotherapy, and immune checkpoint inhibitors.

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