nach oben

Wiener klinische Wochenschrift

Erschienen in:

22.07.2020 | original article

Psoriasis and IgE-mediated allergy: correlation or mutual inhibition?

A prospective cohort study in patients with mild or moderate to severe psoriasis

verfasst von: Anna Essl, Dagmara Loader, Robert Feldmann, Andreas Steiner, Dr. Paul Sator

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 19-20/2021

Einloggen, um Zugang zu erhalten

Summary

Background

Psoriasis is an autoimmune disease caused by overactivation of T_H1 (Type 1 helper cells) and T_H17 (T helper 17) cells. Overactivation of T_H1 cells inhibits the activity of T_H2 cells involved in type 1 allergies, therefore, psoriasis patients might be less affected by type 1 allergies. This study tested if allergies were less frequent in patients with moderate to severe than with mild psoriasis.

Methods

Psoriasis patients at the study site reported possible allergy symptoms and were tested for common allergens by skin prick test and IgE levels. Psoriasis was classified by PASI scores (Psoriasis Area and Severity Index) as mild (PASI <10) or moderate/severe (PASI ≥10). Patients without systemic therapy were assessed separately. Fisher’s exact test was used to test for differences.

Results

A total of 97 patients were included, 21 with mild and 76 with moderate to severe psoriasis. Allergies were found in 27.8%, most commonly against dust mites (23.4%) and grasses (18.1%). Allergies were found in 23.8% of the patients with mild vs. 29.0% allergic patients with moderate to severe psoriasis (P = 0.786). In patients without systemic medication, allergies were found in 21.1% vs. 35.3% (P = 0.463).

Conclusion

Allergy prevalence was not reduced in patients with moderate/severe psoriasis, and generally close to the prevalence in the general Austrian population (24%). The inhibiting effect of psoriasis on type 1 allergies was not confirmed.

Nächster Artikel Long-term impact of olfactory dysfunction on daily life

Nur mit Berechtigung zugänglich

Patel AB, Tsilioni I, Weng Z, Theoharides TC. TNF stimulates IL‑6, CXCL8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin. Exp Dermatol. 2018;27:135–43. https://doi.org/10.1111/exd.13461.CrossRefPubMed

Mansouri Y, Goldenberg G. Biologic safety in psoriasis: review of long-term safety data. J Clin Aesthet Dermatol. 2015;8:30–42.PubMedPubMedCentral

Blumenthal-Barby E. Charakterisierung einer humanen endogenen retroviralen dUTPase als Suszeptibilitätsgen für Psoriasis vulgaris: [Characterization of a human endogenous retroviral dUTPase as susceptibility gene for psoriasis vulgaris] [PhD Thesis]. Berlin: Universitätsmedizin Berlin; 2012.

Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, et al. Sequence and haplotype analysis supports HLA‑C as the psoriasis susceptibility 1 gene. Am J Hum Genet. 2006;78:827–51. https://doi.org/10.1086/503821.CrossRefPubMedPubMedCentral

Guttman-Yassky E, Krueger JG. Atopic dermatitis and psoriasis: two different immune diseases or one spectrum? Curr Opin Immunol. 2017;48:68–73. https://doi.org/10.1016/j.coi.2017.08.008.CrossRefPubMed

Chiricozzi A, Suárez-Fariñas M, Fuentes-Duculan J, Cueto I, Li K, Tian S, et al. Increased expression of interleukin-17 pathway genes in nonlesional skin of moderate-to-severe psoriasis vulgaris. Br J Dermatol. 2016;174:136–45. https://doi.org/10.1111/bjd.14034.CrossRefPubMed

Kreft S, Kreft M, Resman A, Marko P, Kreft KZ. Computer-aided measurement of psoriatic lesion area in a multicenter clinical trial—comparison to physician’s estimations. J Dermatol Sci. 2006;44:21–7. https://doi.org/10.1016/j.jdermsci.2006.05.006.CrossRefPubMed

Langen U, Schmitz R, Steppuhn H. Häufigkeit allergischer Erkrankungen in Deutschland: Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013;56:698–706. https://doi.org/10.1007/s00103-012-1652-7.CrossRefPubMed

Maucher J. Erster österreichischer Allergiebericht: Einschätzung und Realität unterschiedlich. Osterr Arzteztg. 2006;11:56–7.

10.

Averbeck M, Gebhardt C, Emmrich F, Treudler R, Simon JC. Immunologic principles of allergic disease. J Dtsch Dermatol Ges. 2007;5:1015–28. https://doi.org/10.1111/j.1610-0387.2007.06538.x.CrossRefPubMed

11.

Benn CS, Bendixen M, Krause TG, Olesen AB. Questionable coexistence of T(H)1- and T(H)2-related diseases. J Allergy Clin Immunol. 2002;110:328–9. author reply 329–30.CrossRef

12.

Graham-Rowe D. Lifestyle: When allergies got west. Nature. 2011;479:S2–S4.CrossRef

13.

Oriss TB, McCarthy SA, Morel BF, Campana MA, Morel PA. Crossregulation between T helper cell (Th)1 and Th2: Inhibition of Th2 proliferation by IFN-gamma involves interference with IL‑1. J Immunol. 1997;158:3666–72.PubMed

14.

Christophers E. Psoriasis—epidemiology and clinical spectrum. Clin Exp Dermatol. 2001;26:314–20.CrossRef

15.

Hajdarbegovic E, Nijsten T, Westgeest A, Habraken F, Hollestein L, Thio B. Decreased prevalence of atopic features in patients with psoriatic arthritis, but not in psoriasis vulgaris. J Am Acad Dermatol. 2013;68:270–7. https://doi.org/10.1016/j.jaad.2012.07.018.CrossRefPubMed

16.

Mrowietz U, Kragballe K, Reich K, Spuls P, Griffiths CE, Nast A, et al. Definition of treatment goals for moderate to severe psoriasis: A European consensus. Arch Dermatol Res. 2011;303:1–10.CrossRef

17.

Ruëff F, Bergmann K‑C, Brockow K, Fuchs T, Grübl A, Jung K, et al. Hauttests zur Diagnostik von allergischen Soforttypreaktionen: Leitlinie der Deutschen Gesellschaft für Allergologie und klinischen Immunologie (DGAKI). Pneumologie. 2011;65:484–95.CrossRef

18.

Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, et al. Allergy diagnostic testing: An updated practice parameter. Ann Allergy Asthma Immunol. 2008;100:S1–S148.CrossRef

19.

Kleine-Tebbe J, Ballmer-Weber B, Beyer K, Erdmann S, Fuchs T, Henzgen M, et al. In-vitro-Diagnostik und molekulare Grundlagen von IgE-vermittelten Nahrungsmittelallergien: Leitlinie der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI), des Ärzteverbandes Deutscher Allergologen (ÄDA), der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA), der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI) und der Schweizerischen Gesellschaft für Allergologie und Immunologie (SGAI). Allergo J. 2009;18:132–46.

20.

Griebler R, Winkler P, Gaiswinkler S, Delcour J, Jusaszovich B, Nowotny M, et al. Österreichischer Gesundheitsbericht 2016 [Austrian health report 2016]. 2017. Berichtszeitraum 2005–2014/15.

21.

Dittmar D, Uter W, Bauer A, Fortina AB, Bircher AJ, Czarnecka-Operacz M, et al. European Surveillance System on Contact Allergies (ESSCA): polysensitization, 2009–2014. Contact Derm. 2018;78:373–85. https://doi.org/10.1111/cod.12966.CrossRef

22.

Österreichische Gesellschaft für Pneumologie.. Klimawandel verstärkt Risiko für Allergien und Asthma: Klimawandel und die Folgen für die Lungengesundheit – Ergebnisse aus der LEAD-Studie. Wien: ÖGP; 2017.

23.

Asher MI, Montefort S, Björkstén B, Lai CKW, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368:733–43. https://doi.org/10.1016/S0140-6736(06)69283-0.CrossRefPubMed

24.

Schernhammer ES, Vutuc C, Waldhör T, Haidinger G. Time trends of the prevalence of asthma and allergic disease in Austrian children. Pediatr Allergy Immunol. 2008;19:125–31. https://doi.org/10.1111/j.1399-3038.2007.00597.x.CrossRefPubMed

25.

Bjerg A, Sandström T, Lundbäck B, Rönmark E. Time trends in asthma and wheeze in Swedish children 1996–2006: prevalence and risk factors by sex. Allergy. 2010;65:48–55. https://doi.org/10.1111/j.1398-9995.2009.02105.x.CrossRefPubMed

26.

Zöllner IK, Weiland SK, Piechotowski I, Gabrio T, von Mutius E, Link B, et al. No increase in the prevalence of asthma, allergies, and atopic sensitisation among children in Germany: 1992-2001. Thorax. 2005;60:545–8. https://doi.org/10.1136/thx.2004.029561.CrossRefPubMedPubMedCentral

27.

Pigatto PD. Atopy and contact sensitization in psoriasis. Acta Derm Venereol Suppl (Stockh). 2000;80:19–20.CrossRef

28.

Chen C, Zheng X, Duan Q, Yang P, Zheng Y. High serum IgE concentration in patients with psoriasis. Clin Res Dermatol. 2017;4:1–4.

29.

Skaaby T, Husemoen LLN, Thuesen BH, Fenger RV, Linneberg A. Specific IgE positivity against inhalant allergens and development of autoimmune disease. Autoimmunity. 2015;48:282–8. https://doi.org/10.3109/08916934.2014.1003640.CrossRefPubMed

30.

Rabin RL, Levinson AI. The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature. Clin Exp Immunol. 2008;153:19–30. https://doi.org/10.1111/j.1365-2249.2008.03679.x.CrossRefPubMedPubMedCentral

31.

Yan K‑X, Huang Q, Fang X, Zhang Z‑H, Han L, Gadaldi K, et al. IgE and FcεRI are highly expressed on innate cells in psoriasis. Br J Dermatol. 2016;175:122–33. https://doi.org/10.1111/bjd.14459.CrossRefPubMed

32.

Gruber S, Tiringer K, Dehlink E, Eiwegger T, Mayer E, Konstantin H, et al. Allergic sensitization in kidney-transplanted patients prevails under tacrolimus treatment. Clin Exp Allergy. 2011;41:1125–32. https://doi.org/10.1111/j.1365-2222.2011.03761.x.CrossRefPubMed

33.

Ozdemir O. New developments in transplant-acquired allergies. World J Transplant. 2013;3:30–5. https://doi.org/10.5500/wjt.v3.i3.30.CrossRefPubMedPubMedCentral

34.

Bandelier C, Leimgruber A, Wassenberg J, Bart PA, Spertini F. Allergies alimentaires rares. Rev Med Suisse. 2008;4:1024–9.PubMed

35.

Wassenberg J, Bart PA. Modern nutrition and development of new allergies. Rev Med Suisse. 2007;3:1032–7.PubMed

36.

Schernhammer ES, Vutuc C, Waldhör T, Haidinger G. Time trends of the prevalence of asthma and allergic disease in Austrian children. Pediatric Allergy and Immunology. 2008;19(2):125–131CrossRef

37.

de Vos G, Nazari R, Ferastraoaru D, Parikh P, Geliebter R, Pichardo Y, et al. Discordance between aeroallergen specific serum IgE and skin testing in children younger than 4 years. Ann Allergy Asthma Immunol. 2013;110:438–43. https://doi.org/10.1016/j.anai.2013.03.006.CrossRefPubMedPubMedCentral

38.

Bergmann K‑C. Current status of allergy prevalence in Germany: Position paper of the Environmental Medicine Commission of the Robert Koch Institute. 2016.CrossRef

39.

Essl A. Vergleich der Prävalenz von IGE-vermittelten Sensibilisierungen und Allergien bei Patienten mit leichter (PASO 〈 10) und schwerer (PASI 〉 10) Psoriasis vulgaris: [Comparison of the prevalence of IgE mediated sensibilisation and allergy in patients with mild (PASI 〈 10) and severe (PASI 〉 10) psoriasis vulgaris] [Thesis]. Vienna: Medical University Vienna; 2018.

40.

Eyerich S, Onken AT, Weidinger S, Franke A, Nasorri F, Pennino D, et al. Mutual antagonism of T cells causing psoriasis and atopic eczema. N Engl J Med. 2011;365:231–8. https://doi.org/10.1056/NEJMoa1104200.CrossRefPubMed

Titel: Psoriasis and IgE-mediated allergy: correlation or mutual inhibition?
A prospective cohort study in patients with mild or moderate to severe psoriasis
verfasst von: Anna Essl
Dagmara Loader
Robert Feldmann
Andreas Steiner
Dr. Paul Sator
Publikationsdatum: 22.07.2020
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 19-20/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-020-01683-0

Springer Medizin Österreich

Summary

Background

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 19-20/2021

A rare clinical sign—Pneumaturia

Health effects of electronic cigarette (e‑cigarette) use on organ systems and its implications for public health

Low dose intravenous immunoglobulin in addition to cyclophosphamide in systemic sclerosis

I smoke to cope with pain: patients’ perspectives on the link between cigarette smoking and pain

Determinants of health and well-being in adolescents

Pain management in hemophilia: expert recommendations