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Erschienen in: Wiener klinische Wochenschrift 19-20/2021

22.06.2021 | review article

Hearing impairment and diverse health outcomes

An umbrella review of meta-analyses of observational studies

verfasst von: Mike Trott, Dr. Lee Smith, Tao Xiao, Nicola Veronese, Ai Koyanagi, Louis Jacob, Guillermo F. Lopez-Sanchez, Yvonne Barnett, Shahina Pardhan

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 19-20/2021

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Summary

Background

Globally, it is estimated that approximately 1.3 billion people live with some form of hearing impairment. Major causes of hearing loss include infection/disease, age-related factors, and occupational factors. Numerous systematic reviews and meta-analyses have attempted to synthesise literature on these topics. To date there has not been a systematic evaluation of the relationships between hearing impairment and diverse physical, mental, and social outcomes.

Objective

We performed an umbrella review of systematic reviews of observational studies with meta-analyses for any physical disease, biomarkers of disease, mental health or cognitive outcomes, and/or modifiable risk factors associated with hearing impairment.

Methods

For each meta-analytic association, random effects summary effect size, 95% confidence intervals, heterogeneity, evidence for small-study effect, excess significance bias and 95% prediction intervals were calculated, and risk of bias was assessed via the AMSTAR2 tool. These were used to grade significant evidence (p < 0.05) from I to IV, using the recommendations from the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria.

Results

From 3747 studies, 21 were included covering 54 outcomes. Overall, 44/54 outcomes (82%) yielded significant results. Of the highest quality evidence, age-related hearing loss and non-specific hearing impairment were negatively associated with several types of cognitive impairments; pediatric bilateral hearing loss was negatively associated with quality of life, sensorineural hearing loss was positively associated with rheumatoid arthritis and tinnitus was positively associated with temporomandibular disorders.

Conclusion and relevance

Results show moderate quality evidence for associations between several types of hearing impairments and cognitive difficulties, quality of life and systemic diseases such as rheumatoid arthritis. Practitioners and public health policies should note these findings when developing relevant healthcare policies.
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Metadaten
Titel
Hearing impairment and diverse health outcomes
An umbrella review of meta-analyses of observational studies
verfasst von
Mike Trott
Dr. Lee Smith
Tao Xiao
Nicola Veronese
Ai Koyanagi
Louis Jacob
Guillermo F. Lopez-Sanchez
Yvonne Barnett
Shahina Pardhan
Publikationsdatum
22.06.2021
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 19-20/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-021-01893-0

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