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Erschienen in: Wiener klinische Wochenschrift 5-6/2022

24.11.2021 | review article

Frank’s sign and paired ear creases of the helix

Current concepts of significance for morbidity

verfasst von: George S. Stoyanov, Deyan Dzhenkov, Lilyana Petkova, Deyana Velkova, Nikolay Sapundzhiev, Peter Ghenev

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 5-6/2022

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Summary

Frank’s sign (FS) was described in 1973 as an auricular marker for cardiovascular disease presenting as a crease of the auricular lobule. Since its first clinical description, there have been multiple studies underlining the role of FS in a myriad of conditions, such as atherosclerosis, hypertension, cerebrovascular disease, peripheral artery disease, metabolic diseases as well as studies looking at physiological differences in the auricular shape that may mimic FS; however, a complex study to comprehensively analyze the clinical, gross, and histological findings of patients with FS has not yet been performed. Most studies focused on a specific system, mechanism of disease entry. This short review tries to summarize the current knowledge of FS in relation to diseases as well as its clinical classification, histology, and association with the recently described paired ear creases of the helix, as an attempt to reveal the dubious role of FS as a possible prognostic and predictive marker.
Literatur
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Metadaten
Titel
Frank’s sign and paired ear creases of the helix
Current concepts of significance for morbidity
verfasst von
George S. Stoyanov
Deyan Dzhenkov
Lilyana Petkova
Deyana Velkova
Nikolay Sapundzhiev
Peter Ghenev
Publikationsdatum
24.11.2021
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 5-6/2022
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-021-01969-x