Elsevier

The Lancet

Volume 334, Issue 8664, 16 September 1989, Pages 676-677
The Lancet

Letters to the Editor
MYOCARDIAL INFARCTION RISK, EARLOBE CREASE, AND SLEEP APNOEA SYNDROME

https://doi.org/10.1016/S0140-6736(89)90917-3Get rights and content

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    Another pathophysiological explanation to the relationship between COPD and DELC is that several conditions including oxidant-antioxidant imbalances in both the lungs and the circulation, gene polymorphisms, activation of transcription factors, increased plasma pro-inflammatory cytokines, and hypoxia cause endothelial dysfunction.22 Diagonal earlobe crease (DELC) is usually absent at birth and in young children and is more common in the elderly.23 Evrengul et al. evaluated 415 patients for the presence of bilateral ELC and revealed that the prevalence of DELC positively correlated with age, hypertension, male gender, and smoking.24

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