Identification of novel classes for patients with lupus nephritis using two-step cluster model
- 17.01.2022
- original article
Erschienen in:
- Verfasst von
-
Dr. Ting Huang
Dr. Ting Huang
- Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
-
Dr. Shasha Xie
Dr. Shasha Xie
- Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
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Dr. Liqing Ding
Dr. Liqing Ding
- Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
-
Prof. Xiaofeng Zeng
Prof. Xiaofeng Zeng
- Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Dermatologic and Immunologic Diseases, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 100730, Beijing, China
-
Prof. Hui Luo
Korrespondierender Autor Prof. Hui Luo
- Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
- Erschienen in
- Wiener klinische Wochenschrift | Ausgabe 5-6/2022
Summary
Objective
To identify and reclassify the patients in the lupus nephritis (LN) cohort, and to further analyze the prominent clinical features and clinical significance of each cluster.
Methods
In this retrospective cross-sectional study, we used a two-step clustering method to classify 635 patients with LN into different clusters, then we observed the main differences and analyzed relevant clinical significance between the clusters.
Results
Cluster 1 (20.5%) presented with the highest disease severity, patients in this group had the disease for a longer duration and higher systemic lupus erythematosus disease activity index (SLEDAI) score, with multiple positive auto-antibodies and lower complement level. Patients of cluster 2 (20.8%) had lower levels of IgG, IgA and IgM, with renal function being relatively worse in this cluster than in clusters 1 and 3. Cluster 3 was the largest group (58.7%), and the patients in this group showed mild disease severity.
Conclusion
This study reclassified LN patients in a large cohort into three clusters. Our classification might be helpful to implement targeted therapy at various stages of systemic lupus erythematosus.
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- Titel
- Identification of novel classes for patients with lupus nephritis using two-step cluster model
- Verfasst von
-
Dr. Ting Huang
Dr. Shasha Xie
Dr. Liqing Ding
Prof. Xiaofeng Zeng
Prof. Hui Luo
- Publikationsdatum
- 17.01.2022
- Verlag
- Springer Vienna
- Erschienen in
-
Wiener klinische Wochenschrift / Ausgabe 5-6/2022
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671 - DOI
- https://doi.org/10.1007/s00508-021-02001-y
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