Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: psychopraxis. neuropraxis 4/2016

01.09.2016 | Psychiatrie

Benzodiazepine im Fokus

verfasst von: Prim. Priv.-Doz. Dr. Martin Aigner

Erschienen in: psychopraxis. neuropraxis | Ausgabe 4/2016

Einloggen, um Zugang zu erhalten
share
TEILEN

Zusammenfassung

Benzodiazepine (BZDs) haben wegen ihrer guten Verträglichkeit und ihres Sicherheitsprofils eine weite Verbreitung gefunden. Die Langzeiteinnahme erscheint jedoch problematisch und dürfte bei entsprechender Vulnerabilität zu Schlafstörungen, verstärkter Ängstlichkeit, Konzentrationsstörungen bis zu kognitiven Einbußen und körperlichen Beschwerden führen, sodass von einem BZD-Langzeiteinnahmesyndrom gesprochen werden kann, das die Gefahr einer Demenzentwicklung in sich birgt.
Literatur
1.
Zurück zum Zitat Aigner M, Graf A, Freidl M, Prause W, Weiss M, Kaup-Eder B, Saletu B, Bach M (2003) Sleep disturbances in somatoform pain disorder. Psychopathology 36:324–328 CrossRefPubMed Aigner M, Graf A, Freidl M, Prause W, Weiss M, Kaup-Eder B, Saletu B, Bach M (2003) Sleep disturbances in somatoform pain disorder. Psychopathology 36:324–328 CrossRefPubMed
2.
Zurück zum Zitat Amato L, Minozzi S, Vecchi S, Davoli M (2010) Benzodiazepines for alcohol withdrawal. Cochrane Database Syst Rev 17(3):CD005063 Amato L, Minozzi S, Vecchi S, Davoli M (2010) Benzodiazepines for alcohol withdrawal. Cochrane Database Syst Rev 17(3):CD005063
3.
Zurück zum Zitat Bandelow B, Reitt M, Röver C, Michaelis S, Görlich Y, Wedekind D (2015) Efficacy of treatments for anxiety disorders: A meta-analysis. Int Clin Psychopharmacol 30:183–192 CrossRefPubMed Bandelow B, Reitt M, Röver C, Michaelis S, Görlich Y, Wedekind D (2015) Efficacy of treatments for anxiety disorders: A meta-analysis. Int Clin Psychopharmacol 30:183–192 CrossRefPubMed
4.
Zurück zum Zitat Barker MJ, Greenwood KM, Jackson M, Crowe SF (2004) Cognitive effects of long-term benzodiazepine use: A meta-analysis. CNS Drugs 18:37–48 CrossRefPubMed Barker MJ, Greenwood KM, Jackson M, Crowe SF (2004) Cognitive effects of long-term benzodiazepine use: A meta-analysis. CNS Drugs 18:37–48 CrossRefPubMed
5.
Zurück zum Zitat Billioti de Gage S, Pariente A, Bégaud B (2015) Is there really a link between benzodiazepine use and the risk of dementia? Expert Opin Drug Saf 14(5):733–747 CrossRefPubMed Billioti de Gage S, Pariente A, Bégaud B (2015) Is there really a link between benzodiazepine use and the risk of dementia? Expert Opin Drug Saf 14(5):733–747 CrossRefPubMed
6.
Zurück zum Zitat Buscemi N, Vandermeer B, Friesen C, Bialy L, Tubman M, Ospina M, Klassen TP, Witmans M (2007) The efficacy and safety of drug treatments for chronic insomnia in adults: A meta-analysis of RCTs. J Gen Intern Med 22(9):1335–1350 CrossRefPubMedPubMedCentral Buscemi N, Vandermeer B, Friesen C, Bialy L, Tubman M, Ospina M, Klassen TP, Witmans M (2007) The efficacy and safety of drug treatments for chronic insomnia in adults: A meta-analysis of RCTs. J Gen Intern Med 22(9):1335–1350 CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Darker CD, Sweeney BP, Barry JM, Farrell MF, Donnelly-Swift E (2015) Psychosocial interventions for benzodiazepine harmful use, abuse or dependence. Cochrane Database Syst Rev 5:CD009652 Darker CD, Sweeney BP, Barry JM, Farrell MF, Donnelly-Swift E (2015) Psychosocial interventions for benzodiazepine harmful use, abuse or dependence. Cochrane Database Syst Rev 5:CD009652
8.
Zurück zum Zitat Dold M, Li C, Gillies D, Leucht S (2013) Benzodiazepine augmentation of antipsychotic drugs in schizophrenia: A meta-analysis and Cochrane review of randomized controlled trials. Eur Neuropsychopharmacol 23(9):1023–1033 CrossRefPubMed Dold M, Li C, Gillies D, Leucht S (2013) Benzodiazepine augmentation of antipsychotic drugs in schizophrenia: A meta-analysis and Cochrane review of randomized controlled trials. Eur Neuropsychopharmacol 23(9):1023–1033 CrossRefPubMed
9.
Zurück zum Zitat Gould RL, Coulson MC, Patel N, Highton-Williamson E, Howard RJ (2014) Interventions for reducing benzodiazepine use in older people: Meta-analysis of randomised controlled trials. Br J Psychiatry 204(2):98–107 CrossRefPubMed Gould RL, Coulson MC, Patel N, Highton-Williamson E, Howard RJ (2014) Interventions for reducing benzodiazepine use in older people: Meta-analysis of randomised controlled trials. Br J Psychiatry 204(2):98–107 CrossRefPubMed
10.
Zurück zum Zitat Guina J, Rossetter SR, DeRhodes BJ, Nahhas RW, Welton RS (2015) Benzodiazepines for PTSD: A systematic review and meta-analysis. J Psychiatr Pract 21(4):281–303 CrossRefPubMed Guina J, Rossetter SR, DeRhodes BJ, Nahhas RW, Welton RS (2015) Benzodiazepines for PTSD: A systematic review and meta-analysis. J Psychiatr Pract 21(4):281–303 CrossRefPubMed
11.
12.
Zurück zum Zitat Hoff R, Braam AW (2013) Off-label prescriptions in acute psychiatry: A practice-based evaluation. Tijdschr Psychiatr 55(4):233–245 PubMed Hoff R, Braam AW (2013) Off-label prescriptions in acute psychiatry: A practice-based evaluation. Tijdschr Psychiatr 55(4):233–245 PubMed
13.
14.
Zurück zum Zitat Martin JL, Sainz-Pardo M, Furukawa TA, Martín-Sánchez E, Seoane T, Galán C (2007) Benzodiazepines in generalized anxiety disorder: Heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials. J Psychopharmacol 21(7):774–782 CrossRefPubMed Martin JL, Sainz-Pardo M, Furukawa TA, Martín-Sánchez E, Seoane T, Galán C (2007) Benzodiazepines in generalized anxiety disorder: Heterogeneity of outcomes based on a systematic review and meta-analysis of clinical trials. J Psychopharmacol 21(7):774–782 CrossRefPubMed
15.
Zurück zum Zitat Mugunthan K, McGuire T, Glasziou P (2011) Minimal interventions to decrease long-term use of benzodiazepines in primary care: A systematic review and meta-analysis. Br J Gen Pract 61(590):e573–e578 CrossRefPubMedPubMedCentral Mugunthan K, McGuire T, Glasziou P (2011) Minimal interventions to decrease long-term use of benzodiazepines in primary care: A systematic review and meta-analysis. Br J Gen Pract 61(590):e573–e578 CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Onen SH, Alloui A, Gross A, Eschallier A, Dubray C (2001) The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects. J Sleep Res 10:35–42 CrossRefPubMed Onen SH, Alloui A, Gross A, Eschallier A, Dubray C (2001) The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects. J Sleep Res 10:35–42 CrossRefPubMed
17.
Zurück zum Zitat Parr JM, Kavanagh DJ, Cahill L, Mitchell G, McD Young R (2009) Effectiveness of current treatment approaches for benzodiazepine discontinuation: A meta-analysis. Addiction 104(1):13–24 CrossRefPubMed Parr JM, Kavanagh DJ, Cahill L, Mitchell G, McD Young R (2009) Effectiveness of current treatment approaches for benzodiazepine discontinuation: A meta-analysis. Addiction 104(1):13–24 CrossRefPubMed
18.
Zurück zum Zitat Plante DT, Goldstein MR, Cook JD, Smith R, Riedner BA, Rumble ME, Jelenchick L, Roth A, Tononi G, Benca RM, Peterson MJ (2016) Effects of oral temazepam on slow waves during non-rapid eye movement sleep in healthy young adults: A high-density EEG investigation. Int J Psychophysiol 101:25–32 CrossRefPubMed Plante DT, Goldstein MR, Cook JD, Smith R, Riedner BA, Rumble ME, Jelenchick L, Roth A, Tononi G, Benca RM, Peterson MJ (2016) Effects of oral temazepam on slow waves during non-rapid eye movement sleep in healthy young adults: A high-density EEG investigation. Int J Psychophysiol 101:25–32 CrossRefPubMed
19.
Zurück zum Zitat Xing D, Ma XL, Ma JX, Wang J, Yang Y, Chen Y (2014) Association between use of benzodiazepines and risk of fractures: A meta-analysis. Osteoporos Int 25(1):105–120 CrossRefPubMed Xing D, Ma XL, Ma JX, Wang J, Yang Y, Chen Y (2014) Association between use of benzodiazepines and risk of fractures: A meta-analysis. Osteoporos Int 25(1):105–120 CrossRefPubMed
20.
Zurück zum Zitat Winkler A, Auer C, Doering BK, Rief W (2014) Drug treatment of primary insomnia: A meta-analysis of polysomnographic randomized controlled trials. CNS Drugs 28(9):799–816 CrossRefPubMed Winkler A, Auer C, Doering BK, Rief W (2014) Drug treatment of primary insomnia: A meta-analysis of polysomnographic randomized controlled trials. CNS Drugs 28(9):799–816 CrossRefPubMed
Metadaten
Titel
Benzodiazepine im Fokus
verfasst von
Prim. Priv.-Doz. Dr. Martin Aigner
Publikationsdatum
01.09.2016
Verlag
Springer Vienna
Erschienen in
psychopraxis. neuropraxis / Ausgabe 4/2016
Print ISSN: 2197-9707
Elektronische ISSN: 2197-9715
DOI
https://doi.org/10.1007/s00739-016-0336-8