Clone directed drugs
Monoclonal antibody-based treatment options
Antiplasma cell-directed antibodies
11-1F4 (CAEL 101)
Antiserum amyloid P directed drug combination (dezamizumab, miridesap)
Green tea compound epigallactocatechin-3-gallate
Autologous blood stem cell transplant (ASCT)
Heart transplantation in AL
Awareness of AL and MGRS should be intensified and broadened.
Early diagnoses and treatment are of major impact regarding improvement of organ function and overall survival in AL and MGRS.
Treatment should be given in a risk-adapted manner.
The management of treatment side effect and diseases related problems is complex and needs intensive interdisciplinary cooperation.
Daratumumab is highly effective and well tolerated.
Daratumumab is the first and only drug approved up to now (FDA approved since January 15, 2021).