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Wiener klinische Wochenschrift
Erschienen in:

Open Access 10.01.2018 | review article

S(+)-ketamine

Current trends in emergency and intensive care medicine

verfasst von: Prim. Dr. Helmut Trimmel, MSc, PD OA Dr. Raimund Helbok, Prof. Dr. Thomas Staudinger, OA Dr. Wolfgang Jaksch, OÄ Dr. Brigitte Messerer, PD OA Dr. Herbert Schöchl, Prim. Prof. Dr. Rudolf Likar, MSc

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2018

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Summary

S(+)-ketamine, the pure dextrorotatory enantiomer of ketamine has been available for clinical use in analgesia and anesthesia for more than 25 years. The main effects are mediated by non-competitive inhibition of the N-methyl-D-aspartate (NMDA) receptor but S(+)-ketamine also interacts with opioid receptors, monoamine receptors, adenosine receptors and other purinergic receptors. Effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, metabotropic glutamate receptors (mGluR) and L‑type calcium chanels have also been described. S(+)-ketamine stimulates the sympathetic nerve system, making it an ideal drug for analgosedation or induction of anesthesia in instable patients. In addition, the neuroprotective properties, bronchodilatory, antihyperalgesic or antiepileptic effects provide interesting therapeutic options. In this article we discuss the numerous effects of S(+)-ketamine under pharmacological and clinical aspects especially for typical indications in emergency medicine as well as intensive care.
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Metadaten
Titel
S(+)-ketamine
Current trends in emergency and intensive care medicine
verfasst von
Prim. Dr. Helmut Trimmel, MSc
PD OA Dr. Raimund Helbok
Prof. Dr. Thomas Staudinger
OA Dr. Wolfgang Jaksch
OÄ Dr. Brigitte Messerer
PD OA Dr. Herbert Schöchl
Prim. Prof. Dr. Rudolf Likar, MSc
Publikationsdatum
10.01.2018
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 9-10/2018
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1299-3

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