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Erschienen in: memo - Magazine of European Medical Oncology 1/2024

07.11.2023 | case report

Renal crystal-storing histiocytosis successfully treated with bortezomib-based regimen

verfasst von: Dr. Poornima Tadkal, Dr. Siddini Vishwanath, Dr. Vankalakunti Mahesha, Dr. Kishore Babu, Dr. Mallikarjun Kalashetty

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 1/2024

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Summary

Crystal-storing histiocytosis (CSH) represents a rare disease seen in patients with monoclonal gammopathy of unknown significance, multiple myeloma, lymphoplasmocytic lymphoma, and other hematological disorders. In the kidneys, it commonly involves the interstitium but can also involve the glomeruli or the vasculature. Herein we present a case of CSH involving the renal interstitium in a patient who presented with rapidly progressing renal failure. He was treated with cyclophosphamide, dexamethasone and bortezomib-based chemotherapy and afterwards his renal function improved back to baseline. CSH is a rare monoclonal gammopathy affecting the kidneys. The underlying clonal cell type of the aberrant monoclonal protein can be identified, which might help in optimizing the treatment strategy and further patient management.
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Metadaten
Titel
Renal crystal-storing histiocytosis successfully treated with bortezomib-based regimen
verfasst von
Dr. Poornima Tadkal
Dr. Siddini Vishwanath
Dr. Vankalakunti Mahesha
Dr. Kishore Babu
Dr. Mallikarjun Kalashetty
Publikationsdatum
07.11.2023
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 1/2024
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-023-00922-0

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