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Erschienen in: memo - Magazine of European Medical Oncology 1/2018

20.09.2017 | review

Cell free nucleic acids as diagnostic and prognostic marker in leukemia

verfasst von: Maryam Eini, Seyed Ali Nojoumi, Mohammad-Amin Saki, Abbas Khosravi

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 1/2018

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Summary

Nucleic acids in circulation, called cell free DNA (cfDNA) and cell free RNA (cfRNA), have recently been analyzed as suitable diagnostic and prognostic markers in cancer. There have also been several reports about the role of this type of marker in leukemia. The relevant literature was identified by a PubMed search (2000–2017) of English-language literature using the terms “cell free DNA”, “Leukemia” and Micro-RNA. Many quantitative and qualitative cfDNA biomarkers including copy number alteration, mutation, LOH and micro-RNA deregulated expression have been investigated in different studies, indicating promising results to distinguish patients from healthy individuals. The findings of this study indicate that nucleic acids in circulation have a high diagnostic and prognostic value in leukemic patients and, thus, have the potential to be used alongside the usual methods in the management of this disease.
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Metadaten
Titel
Cell free nucleic acids as diagnostic and prognostic marker in leukemia
verfasst von
Maryam Eini
Seyed Ali Nojoumi
Mohammad-Amin Saki
Abbas Khosravi
Publikationsdatum
20.09.2017
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 1/2018
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-017-0357-x

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