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WHO classification of tumors of the nervous system: preview of the upcoming 5th edition

Zeitschrift:: memo - Magazine of European Medical Oncology > Ausgabe 2/2021

Autor:: Elisabeth J. Rushing

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Summary

Identification of the underlying genetic and epigenetic alterations in an increasing number of tumors of the nervous system is contributing to a more clinically relevant classification. In the following article, the 7 cIMPACT-NOW publications, which adumbrate the upcoming 5th edition of the WHO Classification of Tumours of the Central Nervous Sytem are summarized.

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Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. International Agency for Research on Cancer, World Health Organization histological classification of tumours of the central nervous system. 4th ed. Lyon: International Agency for Research on Cancer, WHO; 2016.

Louis DN, Aldape K, Brat DJ, et al. Announcing cIMPACT-NOW: the consortium to inform molecular and practical approaches to CNS tumor taxonomy. Acta Neuropathol. 2017;133:1–3. CrossRef

Louis DN, Wesseling P, Paulus W, et al. cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC). Acta Neuropathol. 2018;135:481–4. CrossRef

Gessi CD, Sahm F, et al. Evidence of H3 K27M mutations in posterior fossa ependymomas. Acta Neuropathol. 2016;132:635–7. CrossRef

Orillac C, Thomas C, Dastagirzada Y, al el. Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation. Acta Neuropathol Commun. 2016;4:84. CrossRef

Louis DN, Giannini C, Capper D, et al. cIMPACT-NOW update 2: diagnostic clarifications for Diffuse Midline Glioma, H3 K27M—mutant and Diffuse Astrocytoma/Anaplastic Astrocytoma, IDH-mutant. Acta Neuropathol. 2018;135:639–42. CrossRef

Brat DJ, Aldape K, Colman H, et al. cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”. Acta Neuropathol. 2018;136:805–10. CrossRef

Ellison DW, Hawkins C, Jones DTW, et al. cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAF ^V600E mutation. Acta Neuropathol. 2019;137:683–7. CrossRef

Brat DJ, Aldape K, Colman H, et al. cIMPACT-NOW update 5: recommended grading criteria and terminologies for IDH-mutant astrocytomas. Acta Neuropathol. 2020;139:603–8. CrossRef

10.

Louis DN, Wesseling P, Aldape K, et al. cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading. Brain Pathol. 2020;30:844–56. CrossRef

11.

Ghasemi DR, Sill M, Okonechnikov K, et al. MYCN amplification drives an aggressive form of spinal ependymoma. Acta Neuropathol. 2019;138:1075–89. CrossRef

12.

Ellison DW, Aldape KD, Capper D, et al. cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors. Brain Pathol. 2020;30:863–6. CrossRef

13.

Cooney TM, Lubanszky E, Prasad R, et al. Diffuse midline glioma: review of epigenetics. J Neurooncol. 2020. https://doi.org/10.1007/s11060-020-03553-1. CrossRefPubMed

14.

Antony R, Solomon D, Lee-Way J, et al. HGG-12. Primary bithalamic glioma with EGFR mutation: a rare case report. Neuro Oncol. 2018;20(Suppl 2):i91. CrossRef

15.

Huse JT, Snuderl M, Jones DTW, et al. Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway. Acta Neuropathol. 2017;133:417–29. CrossRef

16.

Deng MY, Sill M, Sturm D, et al. Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC)—a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14. Neuropathol Appl Neurobiol. 2020;46:422–30. CrossRef

17.

Jonsson P, Lin AL, Young RJ, et al. Genomic correlates of disease progression and treatment response in prospectively characterized gliomas. Clin Cancer Res. 2019;25:5537–47. CrossRef

18.

Capper D, Stichel D, Sahm F, et al. Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience. Acta Neuropathol. 2018;136:181–210. CrossRef

19.

Torre M, Vasudevarja V, Serrano J, et al. Molecular and clinicopathologic features of gliomas harboring NTRK fusions. Acta Neuropathol Commun. 2020;8:107. CrossRef

Titel: WHO classification of tumors of the nervous system: preview of the upcoming 5th edition
Autor:: Elisabeth J. Rushing
Publikationsdatum: 12.02.2021
DOI: https://doi.org/10.1007/s12254-021-00680-x
Verlag: Springer Vienna
Zeitschrift: memo - Magazine of European Medical Oncology An International Journal for Oncology and Haematology Professionals
Ausgabe 2/2021
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076

Springer Medizin Österreich

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WHO classification of tumors of the nervous system: preview of the upcoming 5th edition

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