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01.12.2022 | Review

Special Issue: Novel Diagnostic and Therapeutic Approach Options in Lupus Nephritis

Transcriptome Studies in Lupus Nephritis

verfasst von: Marta E. Alarcón-Riquelme

Erschienen in: Archivum Immunologiae et Therapiae Experimentalis | Ausgabe 1/2022

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Abstract

The present review is aimed at describing the main works that have used gene expression to analyze tissue kidney samples of lupus nephritis patients. Most studies used the gene expression arrays, which enormously advanced our knowledge on the possible mechanisms behind lupus nephritis. However, using bulk gene expression platforms, either as arrays, or as sequencing of RNA is not enough to go into detail of the cells and their molecular patterns and single cell mechanisms of disease. More recently, the first single cell RNA Sequencing study was published and this will also be discussed in the context of lupus nephritis. Single cell RNA sequencing allows to retrieve the genes expressed in each cell in the tissue of interest or in blood. In this context, the results of such studies give us a first glimpse of how a lupus nephritis kidney looks like, but much is still to be done to understand the changes that occur with treatment or with the different pathological subtypes of lupus nephritis and their cellular content.
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Metadaten
Titel
Special Issue: Novel Diagnostic and Therapeutic Approach Options in Lupus Nephritis
Transcriptome Studies in Lupus Nephritis
verfasst von
Marta E. Alarcón-Riquelme
Publikationsdatum
01.12.2022
Verlag
Springer International Publishing
Erschienen in
Archivum Immunologiae et Therapiae Experimentalis / Ausgabe 1/2022
Print ISSN: 0004-069X
Elektronische ISSN: 1661-4917
DOI
https://doi.org/10.1007/s00005-022-00651-y

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