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01.07.2015 | case report | Ausgabe 13-14/2015

Wiener Medizinische Wochenschrift 13-14/2015

Osteogenesis imperfecta type III and hypogonadotropic hypogonadism result in severe bone loss: a case report

Wiener Medizinische Wochenschrift > Ausgabe 13-14/2015
MD Fabian Plachel, MD Ursula Renner, MD Roland Kocijan, MD Christian Muschitz, MD Univ. Doz. Fritz Lomoschitz, MD Prof. Heinrich Resch


We present the case of a 33-year-old male patient with multiple fractures and typical radiographical and clinical characteristics of osteogenesis imperfecta (OI) type III. Furthermore, the patient has suffered from hypogonadotropic hypogonadism since childhood. On the basis of antiresorptive therapy, no further fractures occurred within several years. Recently, recurrent nontraumatic fractures without bone healing were observed. Decreased bone mineral density was assessed by dual X-ray absorptiometry (DXA). High-resolution peripheral quantitative computed tomography (HR-pQCT) showed impaired trabecular bone structure. Due to recurrent fragility fractures and severe deterioration of bone structure, an osteoanabolic treatment with teriparatide was initiated to potentially stimulate fracture healing and to increase bone formation.

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