Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Spektrum der Augenheilkunde 6/2018

12.09.2018 | original article

Long-term follow-up of half-fluence photodynamic therapy in acute central serous chorioretinopathy

verfasst von: MD Eva Smretschnig, MD Stefan Hagen, BSc Jutta Gamper, MD Ilse Krebs, MD Susanne Binder, MD Siamak Ansari-Shahrezaei

Erschienen in: Spektrum der Augenheilkunde | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten
share
TEILEN

Summary

Background

To evaluate the long-term results of indocyanine green angiography(ICGA)-guided verteporfin (Visudyne®, Novartis, Basel, Switzerland) photodynamic therapy (PDT) with half-fluence rate in the treatment of acute symptomatic central serous chorioretinopathy (CSC).

Material and methods

A retrospective review was performed of 12 patients with acute symptomatic CSC verified by spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA), treated with ICGA-guided verteporfin (6 mg/m2)-PDT with half-fluence rate (25 J/cm2). The vision-related quality of life (VR QOL) 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25) was completed by all patients and 82 controls.

Results

Best corrected visual acuity (BCVA) at baseline was 77.5 (±10; n = 12) according to the Early Treatment Diabetic Retinopathy Study (EDTRS) letter score and changed to 89 letters (±9.9; p = 0.0003) at long-term follow-up (83.8 ± 4.8 months after PDT). Baseline contrast sensitivity (CS) was 29.5 ± 4.5 Pelli–Robson letters and increased to 34.5 ± 4.5 letters at long term (p < 0.0006). Baseline central foveal thickness (CFT) was 419 μm and decreased to 242 µm at long term (p < 0.0001). The long-term vision-related quality of life of patients was similar to that of controls.

Conclusion

ICGA-guided half-fluence PDT with verteporfin results in excellent long-term visual improvement in BCVA and CS, a significant reduction of CFT, and high levels of VR QOL.
Literatur
1.
Zurück zum Zitat Chan WM, Lai TY, Lai RY, Tang EW, Liu DT, Lam DS. Safety enhanced photodynamic therapy for chronic central serous chorioretinopathy: one-year results of a prospective study. Retina. 2008;28:85–93. CrossRefPubMed Chan WM, Lai TY, Lai RY, Tang EW, Liu DT, Lam DS. Safety enhanced photodynamic therapy for chronic central serous chorioretinopathy: one-year results of a prospective study. Retina. 2008;28:85–93. CrossRefPubMed
2.
Zurück zum Zitat Gass JD. Pathogenesis of disciform detachment of the neuroepithelium. Am J Ophthalmol. 1967;63:1–139. Gass JD. Pathogenesis of disciform detachment of the neuroepithelium. Am J Ophthalmol. 1967;63:1–139.
3.
Zurück zum Zitat Fok AC, Chan PP, Lam DS, Lai TY. Risk factors for recurrence of serous macular detachment in untreated patients with central serous chorioretinopathy. Ophthalmic Res. 2011;46:160–3. CrossRefPubMed Fok AC, Chan PP, Lam DS, Lai TY. Risk factors for recurrence of serous macular detachment in untreated patients with central serous chorioretinopathy. Ophthalmic Res. 2011;46:160–3. CrossRefPubMed
4.
Zurück zum Zitat Gass JD. Stereoscopic atlas of macular diseases: diagnosis and treatment. 4th ed. Vol. 1. St.Louis: Mosby; 1997. pp. 52–70. Gass JD. Stereoscopic atlas of macular diseases: diagnosis and treatment. 4th ed. Vol. 1. St.Louis: Mosby; 1997. pp. 52–70.
5.
Zurück zum Zitat Han DP, Thompson HS, Folk JC. Differentiation between recently resolved optic neuritis and central serous retinopathy. Use of tests of visual function. Arch Ophthalmol. 1985;103:394–6. CrossRefPubMed Han DP, Thompson HS, Folk JC. Differentiation between recently resolved optic neuritis and central serous retinopathy. Use of tests of visual function. Arch Ophthalmol. 1985;103:394–6. CrossRefPubMed
6.
Zurück zum Zitat Ozkaya A, Alkin Z, Ozveren M, Yazici AT, Taskapili M. The time of resolution and the rate of recurrence in acute central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy: a case-control study. Eye (Lond). 2016;30:1005–10. CrossRef Ozkaya A, Alkin Z, Ozveren M, Yazici AT, Taskapili M. The time of resolution and the rate of recurrence in acute central serous chorioretinopathy following spontaneous resolution and low-fluence photodynamic therapy: a case-control study. Eye (Lond). 2016;30:1005–10. CrossRef
7.
Zurück zum Zitat Piccolino FC, Borgia L. Central serous chorioretinopathy and indocyanine green angiography. Retina. 1994;14:231–42. CrossRefPubMed Piccolino FC, Borgia L. Central serous chorioretinopathy and indocyanine green angiography. Retina. 1994;14:231–42. CrossRefPubMed
8.
Zurück zum Zitat Chan WM, Lai TY, Lai RY, Liu DT, Lam DS. Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy: one-year results of a randomized controlled trial. Ophthalmology. 2008;115:1756–65. CrossRefPubMed Chan WM, Lai TY, Lai RY, Liu DT, Lam DS. Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy: one-year results of a randomized controlled trial. Ophthalmology. 2008;115:1756–65. CrossRefPubMed
9.
Zurück zum Zitat Ober MD, Yannuzzi LA, Do DV, Spaide RF, Bressler NM, Jampol LM, et al. Photodynamic therapy for focal retinal pigment epithelial leaks secondary to central serous chorioretinopathy. Ophthalmology. 2005;112:2088–94. CrossRefPubMed Ober MD, Yannuzzi LA, Do DV, Spaide RF, Bressler NM, Jampol LM, et al. Photodynamic therapy for focal retinal pigment epithelial leaks secondary to central serous chorioretinopathy. Ophthalmology. 2005;112:2088–94. CrossRefPubMed
10.
Zurück zum Zitat Wu ZH, Lai RY, Yip YW, Chan WM, Lam DS, Lai TY. Improvement in multifocal electroretinography after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy. A randomized placebo-controlled trial. Retina. 2011;31:1378–86. CrossRefPubMed Wu ZH, Lai RY, Yip YW, Chan WM, Lam DS, Lai TY. Improvement in multifocal electroretinography after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy. A randomized placebo-controlled trial. Retina. 2011;31:1378–86. CrossRefPubMed
11.
Zurück zum Zitat Zhao MW, Zhou P, Xiao HX, Lv YS, Li CA, Liu GD, et al. Photodynamic therapy for acute central serous chorioretinopathy: the safe effective lowest dose of verteporfin. Retina. 2009;29:1155–61. CrossRefPubMed Zhao MW, Zhou P, Xiao HX, Lv YS, Li CA, Liu GD, et al. Photodynamic therapy for acute central serous chorioretinopathy: the safe effective lowest dose of verteporfin. Retina. 2009;29:1155–61. CrossRefPubMed
12.
Zurück zum Zitat Reibaldi M, Cardascia N, Longo A, Furino C, Avitabile T, Faro S, et al. Standard-fluence versus low-fluence photodynamic therapy in chronic central serous chorioretinopathy: a nonrandomized clinical trial. Am J Ophthalmol. 2010;149:307–15. CrossRefPubMed Reibaldi M, Cardascia N, Longo A, Furino C, Avitabile T, Faro S, et al. Standard-fluence versus low-fluence photodynamic therapy in chronic central serous chorioretinopathy: a nonrandomized clinical trial. Am J Ophthalmol. 2010;149:307–15. CrossRefPubMed
13.
Zurück zum Zitat Smretschnig E, Ansari-Shahrezaei S, Moussa S, Glittenberg C, Krebs I, Binder S. Half-fluence photodynamic therapy in acute central serous chorioretinopathy. Retina. 2012;32:2014–9. CrossRefPubMed Smretschnig E, Ansari-Shahrezaei S, Moussa S, Glittenberg C, Krebs I, Binder S. Half-fluence photodynamic therapy in acute central serous chorioretinopathy. Retina. 2012;32:2014–9. CrossRefPubMed
14.
Zurück zum Zitat Hagen S, Ansari-Shahrezaei S, Smretschnig E, Glittenberg C, Krebs I, Steiner I, et al. Effect of photodynamic therapy on short-wavelength fundus autofluorescence in eyes with acute central serous chorioretinopathy. Retina. 2015;35:223–30. CrossRefPubMed Hagen S, Ansari-Shahrezaei S, Smretschnig E, Glittenberg C, Krebs I, Steiner I, et al. Effect of photodynamic therapy on short-wavelength fundus autofluorescence in eyes with acute central serous chorioretinopathy. Retina. 2015;35:223–30. CrossRefPubMed
15.
Zurück zum Zitat Hagen S, Ansari-Shahrezaei S, Smretschnig E, Glittenberg C, Krebs I, Graf A, et al. The effect of photodynamic therapy on macular sensitivity in eyes with acute central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol. 2013;251:1081–9. CrossRefPubMed Hagen S, Ansari-Shahrezaei S, Smretschnig E, Glittenberg C, Krebs I, Graf A, et al. The effect of photodynamic therapy on macular sensitivity in eyes with acute central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol. 2013;251:1081–9. CrossRefPubMed
16.
Zurück zum Zitat Ferris FL III, Bailey I. Standardizing the measurement of visual acuity for clinical research studies: guidelines from the Eye Care Technology Forum. Ophthalmology. 1996;103:181–2. CrossRefPubMed Ferris FL III, Bailey I. Standardizing the measurement of visual acuity for clinical research studies: guidelines from the Eye Care Technology Forum. Ophthalmology. 1996;103:181–2. CrossRefPubMed
17.
Zurück zum Zitat Mangione CM, Lee PP, Gutierrez PR, Spritzer K, Berry S, Hays RD, National Eye Institute Visual Function Questionnaire Field Test Investigators. Development of the 25-item national eye institute visual function questionnaire. Arch Ophthalmol. 2001;119:1050–8. CrossRefPubMed Mangione CM, Lee PP, Gutierrez PR, Spritzer K, Berry S, Hays RD, National Eye Institute Visual Function Questionnaire Field Test Investigators. Development of the 25-item national eye institute visual function questionnaire. Arch Ophthalmol. 2001;119:1050–8. CrossRefPubMed
18.
Zurück zum Zitat Maaranen T, Mäntyjärvi M. Contrast sensitivity in patients recovered from central serous chorioretinopathy. Int Ophthalmol. 1999;23:31–5. CrossRef Maaranen T, Mäntyjärvi M. Contrast sensitivity in patients recovered from central serous chorioretinopathy. Int Ophthalmol. 1999;23:31–5. CrossRef
19.
Zurück zum Zitat Rubin GS, Bandeen-Roche K, Huang GH, Muñoz B, Schein OD, Fried LP, et al. The association of multiple visual impairments with self report visual disability: SEE project. Invest Ophthalmol Vis Sci. 2001;42:64–72. Rubin GS, Bandeen-Roche K, Huang GH, Muñoz B, Schein OD, Fried LP, et al. The association of multiple visual impairments with self report visual disability: SEE project. Invest Ophthalmol Vis Sci. 2001;42:64–72.
21.
Zurück zum Zitat Rubin GS. Reliability and sensitivity of clinical contrast sensitivity tests. Clin Vis Sci. 1988;2:169–77. Rubin GS. Reliability and sensitivity of clinical contrast sensitivity tests. Clin Vis Sci. 1988;2:169–77.
22.
Zurück zum Zitat Kyo T, Yuzawa M, Tochigi K, Yamaguchi T, Shimozuma K, Fukuhara S, et al. Assessment of the quality of life in patients with age-related macular degeneration 1 year after photodynamic therapy. Nippon Ganka Gakkai Zasshi. 2007;111:315–21. PubMed Kyo T, Yuzawa M, Tochigi K, Yamaguchi T, Shimozuma K, Fukuhara S, et al. Assessment of the quality of life in patients with age-related macular degeneration 1 year after photodynamic therapy. Nippon Ganka Gakkai Zasshi. 2007;111:315–21. PubMed
23.
Zurück zum Zitat Mozaffarieh M, Krepler K, Heinzl H, Sacu S, Wedrich A. Visual function, quality of life and patient satisfaction after ophthalmic surgery: a comparative study. Ophthalmologica. 2004;218:26–30. CrossRefPubMed Mozaffarieh M, Krepler K, Heinzl H, Sacu S, Wedrich A. Visual function, quality of life and patient satisfaction after ophthalmic surgery: a comparative study. Ophthalmologica. 2004;218:26–30. CrossRefPubMed
24.
Zurück zum Zitat Türkcü FM, Sahin A, Bez Y, Yüksel H, Cinar Y, Kürşat, et al. Vision-related quality of life in patients with chronic central serous chorioretinopathy. Semin Ophthalmol. 2015;30:272–5. CrossRefPubMed Türkcü FM, Sahin A, Bez Y, Yüksel H, Cinar Y, Kürşat, et al. Vision-related quality of life in patients with chronic central serous chorioretinopathy. Semin Ophthalmol. 2015;30:272–5. CrossRefPubMed
25.
Zurück zum Zitat Smretschnig E, Falkner-Radler CI, Binder S, Spörl J, Ristl R, Glittenberg C, et al. Vision-related quality of life and visual function after retinal detachment surgery. Retina. 2016;36:967–73. CrossRefPubMed Smretschnig E, Falkner-Radler CI, Binder S, Spörl J, Ristl R, Glittenberg C, et al. Vision-related quality of life and visual function after retinal detachment surgery. Retina. 2016;36:967–73. CrossRefPubMed
26.
Zurück zum Zitat Okamoto F, Okamoto Y, Fukuda S, Hiraoka T, Oshika T. Vision-related quality of life and visual function after vitrectomy for various vitreoretinal disorders. Invest Ophthalmol Vis Sci. 2010;51:744–51. CrossRefPubMed Okamoto F, Okamoto Y, Fukuda S, Hiraoka T, Oshika T. Vision-related quality of life and visual function after vitrectomy for various vitreoretinal disorders. Invest Ophthalmol Vis Sci. 2010;51:744–51. CrossRefPubMed
27.
Zurück zum Zitat Okamoto F, Okamoto Y, Hiraoka T, Hiraoka T, Oshika T. Vision-related quality of life and visual function after retinal detachment surgery. Am J Ophthalmol. 2008;146:85–90. CrossRefPubMed Okamoto F, Okamoto Y, Hiraoka T, Hiraoka T, Oshika T. Vision-related quality of life and visual function after retinal detachment surgery. Am J Ophthalmol. 2008;146:85–90. CrossRefPubMed
28.
Zurück zum Zitat Mason JO, Neimkin MG, Mason JO, Friedman DA, Feist RM, Thomley ML, et al. Safety, efficacy, and quality of life following sutureless vitrectomy for symptomatic vitreous floaters. Retina. 2014;34:1055–61. CrossRefPubMed Mason JO, Neimkin MG, Mason JO, Friedman DA, Feist RM, Thomley ML, et al. Safety, efficacy, and quality of life following sutureless vitrectomy for symptomatic vitreous floaters. Retina. 2014;34:1055–61. CrossRefPubMed
29.
Zurück zum Zitat Okamoto F, Okamoto Y, Fukuda S, Hiraoka T, Oshika T. Vision-related quality of life and visual function following vitrectomy for proliferative diabetic retinopathy. Am J Ophthalmol. 2008;145:1031–6. CrossRefPubMed Okamoto F, Okamoto Y, Fukuda S, Hiraoka T, Oshika T. Vision-related quality of life and visual function following vitrectomy for proliferative diabetic retinopathy. Am J Ophthalmol. 2008;145:1031–6. CrossRefPubMed
30.
Zurück zum Zitat Fukuda S, Okamoto F, Yuasa M, Kunikata T, Okamoto Y, Hiraoka T, et al. Vision-related quality of life and visual function in patients undergoing vitrectomy, gas tamponade and cataract surgery for macular hole. J Ophthalmol. 2009;93:1595–9. Fukuda S, Okamoto F, Yuasa M, Kunikata T, Okamoto Y, Hiraoka T, et al. Vision-related quality of life and visual function in patients undergoing vitrectomy, gas tamponade and cataract surgery for macular hole. J Ophthalmol. 2009;93:1595–9.
31.
Zurück zum Zitat Okamoto Y, Okamoto F, Hiraoka T, Oshika T. Vision-related quality of life and visual function following intravitreal bevacizumab injection for persistent diabetic macular edema after vitrectomy. Jpn J Ophthalmol. 2014;58:369–74. CrossRefPubMed Okamoto Y, Okamoto F, Hiraoka T, Oshika T. Vision-related quality of life and visual function following intravitreal bevacizumab injection for persistent diabetic macular edema after vitrectomy. Jpn J Ophthalmol. 2014;58:369–74. CrossRefPubMed
33.
Zurück zum Zitat Zou H, Zhang X, Xu X, Liu H, Bai L, Xu X. Vision-related quality of life and self-rated satisfaction outcomes of rhegmatogenous retinal detachment surgery: three-year prospective study. PLoS ONE. 2011;6:e28597. CrossRefPubMedPubMedCentral Zou H, Zhang X, Xu X, Liu H, Bai L, Xu X. Vision-related quality of life and self-rated satisfaction outcomes of rhegmatogenous retinal detachment surgery: three-year prospective study. PLoS ONE. 2011;6:e28597. CrossRefPubMedPubMedCentral
34.
Zurück zum Zitat Ghazi-Nouri SM, Tranos PG, Rubin GS, Adams ZC, Charteris DG. Visual function and quality of life following vitrectomy and epiretinal membrane peel surgery. Br J Ophthalmol. 2006;90:559–62. CrossRefPubMedPubMedCentral Ghazi-Nouri SM, Tranos PG, Rubin GS, Adams ZC, Charteris DG. Visual function and quality of life following vitrectomy and epiretinal membrane peel surgery. Br J Ophthalmol. 2006;90:559–62. CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Tranos PG, Ghazi-Nouri SM, Rubin GS, Adams ZC, Charteris DG. Visual function and subjective perception of visual ability after macular hole surgery. Am J Ophthalmol. 2004;138:995–1002. CrossRefPubMed Tranos PG, Ghazi-Nouri SM, Rubin GS, Adams ZC, Charteris DG. Visual function and subjective perception of visual ability after macular hole surgery. Am J Ophthalmol. 2004;138:995–1002. CrossRefPubMed
36.
Zurück zum Zitat Okamoto F, Okamoto Y, Hiraoka T, Oshika T. Effect of vitrectomy for epiretinal membrane on visual function and vision-related quality of life. Am J Ophthalmol. 2009;147:869–74. CrossRefPubMed Okamoto F, Okamoto Y, Hiraoka T, Oshika T. Effect of vitrectomy for epiretinal membrane on visual function and vision-related quality of life. Am J Ophthalmol. 2009;147:869–74. CrossRefPubMed
37.
Zurück zum Zitat Lahousen T, Painold A, Luxenberger W, Schienle A, Kapfhammer HP, Ille R. Psychological factors associated with acute and chronic central serous chorioretinopathy. Nord J Psychiatry. 2016;70:24–30. CrossRefPubMed Lahousen T, Painold A, Luxenberger W, Schienle A, Kapfhammer HP, Ille R. Psychological factors associated with acute and chronic central serous chorioretinopathy. Nord J Psychiatry. 2016;70:24–30. CrossRefPubMed
38.
Zurück zum Zitat Lai TY, Wong RL, Chan WM. Long-term outcome of half-dose Verteporfin photodynamic therapy for the treatment of central serous chorioretinopathy (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2015;113:T81–T827. Lai TY, Wong RL, Chan WM. Long-term outcome of half-dose Verteporfin photodynamic therapy for the treatment of central serous chorioretinopathy (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2015;113:T81–T827.
39.
Zurück zum Zitat Kitzmann AS, Pulido JS, Diehl NN, Hodge DO, Burke JP. The incidence of central serous chorioretinopathy in Olmsted County, Minnesota, 1980–2002. Ophthalmology. 2008;115:169–73. CrossRefPubMed Kitzmann AS, Pulido JS, Diehl NN, Hodge DO, Burke JP. The incidence of central serous chorioretinopathy in Olmsted County, Minnesota, 1980–2002. Ophthalmology. 2008;115:169–73. CrossRefPubMed
Metadaten
Titel
Long-term follow-up of half-fluence photodynamic therapy in acute central serous chorioretinopathy
verfasst von
MD Eva Smretschnig
MD Stefan Hagen
BSc Jutta Gamper
MD Ilse Krebs
MD Susanne Binder
MD Siamak Ansari-Shahrezaei
Publikationsdatum
12.09.2018
Verlag
Springer Vienna
Erschienen in
Spektrum der Augenheilkunde / Ausgabe 6/2018
Print ISSN: 0930-4282
Elektronische ISSN: 1613-7523
DOI
https://doi.org/10.1007/s00717-018-0412-y