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The effect of photodynamic therapy on macular sensitivity in eyes with acute central serous chorioretinopathy

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

To evaluate the effect of half-fluence rate indocyanine green angiography (ICGA)-guided verteporfin photodynamic therapy (PDT) on macular sensitivity (MS) in eyes with acute symptomatic central serous chorioretinopathy (CSC).

Methods

Single-center consecutive case series by retrospective chart review. Sixteen eyes of 16 patients with acute CSC of 3 months duration or less, treated with half-fluence (25 mJ/cm2) ICGA-guided verteporfin PDT were reviewed. At baseline and after 1, 3, and 6 months, all patients underwent MS testing of the central 20 °, MS testing of the retinal area covered by the PDT laser spot (MSLS), and evaluation of fixation stability (FS) for the central two degrees with the MP-1 microperimeter (Nidek, Vigonza, Italy).

Results

Macular sensitivity improved from 16.4 ± 3.0 dB at baseline (n = 16) to 18.2 ± 2.4 dB (p < 0.001) at 1 month (n = 16). At the 3-month (n = 13) and 6-month (n = 12) follow-up, MS stabilized at 19.5 ± 0.9 dB (p = 0.21) and 19.0 ± 1.3 dB (p = 0.74), without changes when compared to respective precedent follow-up. Mean MSLS improved from 12.9 ± 5.4 dB at baseline to 16.4 ± 4.9 dB (p < 0.001) after 1 month. At the 3- and 6-month follow-up, MSLS was 19.1 ± 1.2 dB (p = 0.1) and 18.9 ± 1.9 dB (p = 0.8) respectively. Mean FS at the central 2 ° was 78.8 ± 30.4 % before treatment and 81.8 ± 29.5 % (p = 0.7), 81.9 ± 27.5 % (p = 0.7) and 83.6 ± 17.1 % (p = 0.5) respectively 1, 3 and 6 months after treatment.

Conclusion

Half-fluence (25 mJ/cm2) PDT significantly increased mean MS of central 20 ° and mean MSLS, in eyes with acute symptomatic CSC. Fixation stability was stable at baseline and throughout 6 months of follow-up.

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Conflicts of interest

The authors have no conflict of interest to declare.

Financial support

No financial support was provided for this study.

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Authors and Affiliations

  1. The Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Juchgasse 25, 1030, Wien, Austria

    Stefan Hagen, Siamak Ansari-Shahrezaei, Eva Smretschnig, Carl Glittenberg, Ilse Krebs & Susanne Binder

  2. Department of Ophthalmology, Rudolf Foundation Clinic, Vienna, Juchgasse 25, 1030, Wien, Austria

    Stefan Hagen, Siamak Ansari-Shahrezaei, Eva Smretschnig, Carl Glittenberg, Ilse Krebs & Susanne Binder

  3. Department of Ophthalmology, Medical University of Graz, Graz, Auenbruggerplatz 4, 8036, Graz, Austria

    Siamak Ansari-Shahrezaei

  4. Retina Center Vienna, Vienna, Jacquingasse 41, 1030, Wien, Austria

    Siamak Ansari-Shahrezaei & Susanne Binder

  5. Core Unit for Medical Statistics and Informatics, Medical University of Vienna, Vienna, Spitalgasse 23, 1090, Wien, Austria

    Alexandra Graf

Authors
  1. Stefan Hagen
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  2. Siamak Ansari-Shahrezaei
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  3. Eva Smretschnig
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  4. Carl Glittenberg
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  5. Ilse Krebs
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  6. Alexandra Graf
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  7. Susanne Binder
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Corresponding author

Correspondence to Siamak Ansari-Shahrezaei.

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The authors have full control of all primary data, and they agree to allow Graefe's Archive for Clinical and Experimental Ophthalmology to review their data upon request.

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Hagen, S., Ansari-Shahrezaei, S., Smretschnig, E. et al. The effect of photodynamic therapy on macular sensitivity in eyes with acute central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 251, 1081–1089 (2013). https://doi.org/10.1007/s00417-012-2139-9

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  • DOI: https://doi.org/10.1007/s00417-012-2139-9

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