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Erschienen in: Wiener klinisches Magazin 4/2019

07.08.2019 | Kardiologie | Kardiologie

Bedeutung von Biomarkern bei akuter Herzinsuffizienz

verfasst von: Dr. Kristian Hellenkamp, Univ.-Prof. DDr. Stephan von Haehling

Erschienen in: Wiener klinisches Magazin | Ausgabe 4/2019

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Zusammenfassung

Bei Patienten mit akuter Dyspnoe können Biomarker helfen zwischen akuter Herzinsuffizienz und Luftnot nichtkardialer Genese zu unterscheiden. Hierbei sind vor allem die natriuretischen Peptide von großer praktischer Bedeutung. Sie sollten im Rahmen der Aufnahme bei allen Patienten mit akuter Luftnot bestimmt werden. Einen hohen Stellenwert hat insbesondere deren hoher negativer prädiktiver Wert, der den weitgehenden Ausschluss einer Herzinsuffizienz bei normwertigen natriuretischen Peptiden erlaubt. Zur Verfügung stehen Assays für das natriuretische Peptid vom B‑Typ (BNP), das N‑terminale pro-natriuretische Peptid vom B‑Typ (NT-proBNP) und das mittregionale pro-atriale natriuretische Peptid (MR-proANP) mit unterschiedlichen Grenzwerten. Bei Patienten, die mit einem Angiotensinrezeptor-Neprilysin-Inhibitor behandelt werden, muss NT-proBNP (oder MR-proANP) zur Beurteilung verwendet werden, da BNP durch die Medikamentenwirkung gesteigert wird und daher keine adäquate Aussage zur Krankheitsschwere zulässt. Neben der gut etablierten diagnostischen Bedeutung bei der akuten Herzinsuffizienz können die natriuretischen Peptide auch eine Rolle bei der Beurteilung der Krankheitsschwere und bei der Prognoseabschätzung spielen. Neben den natriuretischen Peptiden existieren zahlreiche weitere Biomarker, die verschiedene pathophysiologische Vorgänge der Herzinsuffizienz widerspiegeln. Ob diese Biomarker den Sprung in die klinische Routine schaffen, bleibt abzuwarten.
Literatur
1.
Zurück zum Zitat Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, Authors/Task Force Members (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37(27):2129–2200 CrossRefPubMed Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, Authors/Task Force Members (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 37(27):2129–2200 CrossRefPubMed
2.
Zurück zum Zitat Haass M, Katus HA (Hrsg) (2005) Diagnostische Marker in der Kardiologie. UNI-MED Science, Bremen London Boston Haass M, Katus HA (Hrsg) (2005) Diagnostische Marker in der Kardiologie. UNI-MED Science, Bremen London Boston
4.
Zurück zum Zitat Chow SL, Maisel AS, Anand I, Bozkurt B, de Boer RA, Felker GM, Fonarow GC, Greenberg B, Januzzi JL Jr, Kiernan MS, Liu PP, Wang TJ, Yancy CW, Zile MR; American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology; Council on Basic Cardiovascular Sciences; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Council on Quality of Care and Outcomes Research (2017) Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association. Circulation 135(22):e1054–e1091 Chow SL, Maisel AS, Anand I, Bozkurt B, de Boer RA, Felker GM, Fonarow GC, Greenberg B, Januzzi JL Jr, Kiernan MS, Liu PP, Wang TJ, Yancy CW, Zile MR; American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology; Council on Basic Cardiovascular Sciences; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Council on Quality of Care and Outcomes Research (2017) Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association. Circulation 135(22):e1054–e1091
6.
Zurück zum Zitat Harjola VP, Parissis J, Brunner-La Rocca HP, Čelutkienė J, Chioncel O, Collins SP, De Backer D, Filippatos GS, Gayat E, Hill L, Lainscak M, Lassus J, Masip J, Mebazaa A, Miró Ò, Mortara A, Mueller C, Mullens W, Nieminen MS, Rudiger A, Ruschitzka F, Seferovic PM, Sionis A, Vieillard-Baron A, Weinstein JM, de Boer RA, Crespo-Leiro MG, Piepoli M, Riley JP (2018) Comprehensive in-hospital monitoring in acute heart failure: applications for clinical practice and future directions for research. A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur J Heart Fail 20(7):1081–1099 CrossRefPubMed Harjola VP, Parissis J, Brunner-La Rocca HP, Čelutkienė J, Chioncel O, Collins SP, De Backer D, Filippatos GS, Gayat E, Hill L, Lainscak M, Lassus J, Masip J, Mebazaa A, Miró Ò, Mortara A, Mueller C, Mullens W, Nieminen MS, Rudiger A, Ruschitzka F, Seferovic PM, Sionis A, Vieillard-Baron A, Weinstein JM, de Boer RA, Crespo-Leiro MG, Piepoli M, Riley JP (2018) Comprehensive in-hospital monitoring in acute heart failure: applications for clinical practice and future directions for research. A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur J Heart Fail 20(7):1081–1099 CrossRefPubMed
7.
Zurück zum Zitat Dao Q, Krishnaswamy P, Kazanegra R, Harrison A, Amirnovin R, Lenert L, Clopton P, Alberto J, Hlavin P, Maisel AS (2001) Utility of B‑type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting. J Am Coll Cardiol 37(2):379–385 CrossRefPubMed Dao Q, Krishnaswamy P, Kazanegra R, Harrison A, Amirnovin R, Lenert L, Clopton P, Alberto J, Hlavin P, Maisel AS (2001) Utility of B‑type natriuretic peptide in the diagnosis of congestive heart failure in an urgent-care setting. J Am Coll Cardiol 37(2):379–385 CrossRefPubMed
8.
Zurück zum Zitat Morrison LK, Harrison A, Krishnaswamy P, Kazanegra R, Clopton P, Maisel A (2002) Utility of a rapid B‑natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea. J Am Coll Cardiol 39(2):202–209 CrossRefPubMed Morrison LK, Harrison A, Krishnaswamy P, Kazanegra R, Clopton P, Maisel A (2002) Utility of a rapid B‑natriuretic peptide assay in differentiating congestive heart failure from lung disease in patients presenting with dyspnea. J Am Coll Cardiol 39(2):202–209 CrossRefPubMed
9.
Zurück zum Zitat Laufs U, Anker SD, Falk V, Pieske B, Baldus S, Perings CA, Birner C (2017) Kommentar zu den Leitlinien der Europäischen Gesellschaft für Kardiologie (ESC) zur Diagnostik und Behandlung der akuten und chronischen Herzinsuffizienz. Kardiologe 11:183–192 CrossRef Laufs U, Anker SD, Falk V, Pieske B, Baldus S, Perings CA, Birner C (2017) Kommentar zu den Leitlinien der Europäischen Gesellschaft für Kardiologie (ESC) zur Diagnostik und Behandlung der akuten und chronischen Herzinsuffizienz. Kardiologe 11:183–192 CrossRef
10.
Zurück zum Zitat Roberts E, Ludman AJ, Dworzynski K, Al-Mohammad A, Cowie MR, McMurray JJ, Mant J (2015) NICE Guideline Development Group for Acute Heart Failure. The diagnostic accuracy of the natriuretic peptides in heart failure: systematic review and diagnostic meta-analysis in the acute care setting. BMJ 350:h910 CrossRefPubMedPubMedCentral Roberts E, Ludman AJ, Dworzynski K, Al-Mohammad A, Cowie MR, McMurray JJ, Mant J (2015) NICE Guideline Development Group for Acute Heart Failure. The diagnostic accuracy of the natriuretic peptides in heart failure: systematic review and diagnostic meta-analysis in the acute care setting. BMJ 350:h910 CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Maisel A, Mueller C, Nowak R, Peacock WF, Landsberg JW, Ponikowski P, Mockel M, Hogan C, Wu AH, Richards M, Clopton P, Filippatos GS, Di Somma S, Anand I, Ng L, Daniels LB, Neath SX, Christenson R, Potocki M, McCord J, Terracciano G, Kremastinos D, Hartmann O, von Haehling S, Bergmann A, Morgenthaler NG, Anker SD (2010) Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial. J Am Coll Cardiol 55(19):2062–2076 CrossRefPubMed Maisel A, Mueller C, Nowak R, Peacock WF, Landsberg JW, Ponikowski P, Mockel M, Hogan C, Wu AH, Richards M, Clopton P, Filippatos GS, Di Somma S, Anand I, Ng L, Daniels LB, Neath SX, Christenson R, Potocki M, McCord J, Terracciano G, Kremastinos D, Hartmann O, von Haehling S, Bergmann A, Morgenthaler NG, Anker SD (2010) Mid-region pro-hormone markers for diagnosis and prognosis in acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial. J Am Coll Cardiol 55(19):2062–2076 CrossRefPubMed
12.
Zurück zum Zitat Statistisches Bundesamt (Destatis) (2017) Diagnosedaten der Patienten und Patientinnen in Krankenhäusern (einschl. Sterbe- und Stundenfälle) 2016. Fachserie 12 Reihe 6.2.1 Statistisches Bundesamt (Destatis) (2017) Diagnosedaten der Patienten und Patientinnen in Krankenhäusern (einschl. Sterbe- und Stundenfälle) 2016. Fachserie 12 Reihe 6.2.1
13.
Zurück zum Zitat Statistisches Bundesamt (Destatis) (2017) Todesursachen in Deutschland 2015. Fachserie 12 Reihe 4 Statistisches Bundesamt (Destatis) (2017) Todesursachen in Deutschland 2015. Fachserie 12 Reihe 4
14.
Zurück zum Zitat SOLVD Investigators, Yusuf S, Pitt B, Davis CE, Hood WB, Cohn JN (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325(5):293–302 CrossRef SOLVD Investigators, Yusuf S, Pitt B, Davis CE, Hood WB, Cohn JN (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325(5):293–302 CrossRef
15.
Zurück zum Zitat McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, PARADIGM-HF Investigators and Committees (2014) Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 371(11):993–1004 CrossRefPubMed McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, PARADIGM-HF Investigators and Committees (2014) Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 371(11):993–1004 CrossRefPubMed
17.
Zurück zum Zitat Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola VP, Hochadel M, Komajda M, Lassus J, Lopez-Sendon JL, Ponikowski P, Tavazzi L (2006) EuroHeart Survey Investigators; Heart Failure Association, European Society of Cardiology. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J 27(22):2725–2736 CrossRefPubMed Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola VP, Hochadel M, Komajda M, Lassus J, Lopez-Sendon JL, Ponikowski P, Tavazzi L (2006) EuroHeart Survey Investigators; Heart Failure Association, European Society of Cardiology. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J 27(22):2725–2736 CrossRefPubMed
18.
Zurück zum Zitat Harjola VP, Follath F, Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Hochadel M, Komajda M, Lopez-Sendon JL, Ponikowski P, Tavazzi L (2010) Characteristics, outcomes, and predictors of mortality at 3 months and 1 year in patients hospitalized for acute heart failure. Eur J Heart Fail 12(3):239–248 CrossRefPubMed Harjola VP, Follath F, Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Hochadel M, Komajda M, Lopez-Sendon JL, Ponikowski P, Tavazzi L (2010) Characteristics, outcomes, and predictors of mortality at 3 months and 1 year in patients hospitalized for acute heart failure. Eur J Heart Fail 12(3):239–248 CrossRefPubMed
19.
Zurück zum Zitat Peacock WF, Emerman C, Costanzo MR, Diercks DB, Lopatin M, Fonarow GC (2009) Early vasoactive drugs improve heart failure outcomes. Congest Heart Fail 15(6):256–264 CrossRefPubMed Peacock WF, Emerman C, Costanzo MR, Diercks DB, Lopatin M, Fonarow GC (2009) Early vasoactive drugs improve heart failure outcomes. Congest Heart Fail 15(6):256–264 CrossRefPubMed
20.
Zurück zum Zitat Santaguida PL, Don-Wauchope AC, Oremus M, McKelvie R, Ali U, Hill SA, Balion C, Booth RA, Brown JA, Bustamam A, Sohel N, Raina P (2014) BNP and NT-proBNP as prognostic markers in persons with acute decompensated heart failure: a systematic review. Heart Fail Rev 19(4):453–470 CrossRefPubMed Santaguida PL, Don-Wauchope AC, Oremus M, McKelvie R, Ali U, Hill SA, Balion C, Booth RA, Brown JA, Bustamam A, Sohel N, Raina P (2014) BNP and NT-proBNP as prognostic markers in persons with acute decompensated heart failure: a systematic review. Heart Fail Rev 19(4):453–470 CrossRefPubMed
21.
Zurück zum Zitat Kisch B (1956) Electron microscopy of the atrium of the heart. I. Guinea pig. Exp Med Surg 14(2–3):99–112 PubMed Kisch B (1956) Electron microscopy of the atrium of the heart. I. Guinea pig. Exp Med Surg 14(2–3):99–112 PubMed
22.
Zurück zum Zitat de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28(1):89–94 CrossRefPubMed de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28(1):89–94 CrossRefPubMed
23.
Zurück zum Zitat Kangawa K, Matsuo H (1984) Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP). Biochem Biophys Res Commun 118(1):131–139 CrossRefPubMed Kangawa K, Matsuo H (1984) Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP). Biochem Biophys Res Commun 118(1):131–139 CrossRefPubMed
24.
Zurück zum Zitat Sudoh T, Kangawa K, Minamino N, Matsuo H (1988) A new natriuretic peptide in porcine brain. Nature 332(6159):78–81 CrossRefPubMed Sudoh T, Kangawa K, Minamino N, Matsuo H (1988) A new natriuretic peptide in porcine brain. Nature 332(6159):78–81 CrossRefPubMed
25.
Zurück zum Zitat Nishikimi T, Kuwahara K, Nakao K (2011) Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides. J Cardiol 57(2):131–140 CrossRefPubMed Nishikimi T, Kuwahara K, Nakao K (2011) Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides. J Cardiol 57(2):131–140 CrossRefPubMed
26.
Zurück zum Zitat Morgenthaler NG, Struck J, Thomas B, Bergmann A (2004) Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma. Clin Chem 50(1):234–236 CrossRefPubMed Morgenthaler NG, Struck J, Thomas B, Bergmann A (2004) Immunoluminometric assay for the midregion of pro-atrial natriuretic peptide in human plasma. Clin Chem 50(1):234–236 CrossRefPubMed
27.
Zurück zum Zitat Sudoh T, Minamino N, Kangawa K, Matsuo H (1990) C‑type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun 168(2):863–870 CrossRefPubMed Sudoh T, Minamino N, Kangawa K, Matsuo H (1990) C‑type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun 168(2):863–870 CrossRefPubMed
28.
29.
Zurück zum Zitat Mangiafico S, Costello-Boerrigter LC, Andersen IA, Cataliotti A, Burnett JC Jr. (2013) Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics. Eur Heart J 34(12):886–893c CrossRefPubMed Mangiafico S, Costello-Boerrigter LC, Andersen IA, Cataliotti A, Burnett JC Jr. (2013) Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics. Eur Heart J 34(12):886–893c CrossRefPubMed
30.
Zurück zum Zitat Packer M, McMurray JJ, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile M, Andersen K, Arango JL, Arnold JM, Bělohlávek J, Böhm M, Boytsov S, Burgess LJ, Cabrera W, Calvo C, Chen CH, Dukat A, Duarte YC, Erglis A, Fu M, Gomez E, Gonzàlez-Medina A, Hagège AA, Huang J, Katova T, Kiatchoosakun S, Kim KS, Kozan Ö, Llamas EB, Martinez F, Merkely B, Mendoza I, Mosterd A, Negrusz-Kawecka M, Peuhkurinen K, Ramires FJ, Refsgaard J, Rosenthal A, Senni M, Sibulo AS Jr, Silva-Cardoso J, Squire IB, Starling RC, Teerlink JR, Vanhaecke J, Vinereanu D, Wong RC, PARADIGM-HF Investigators and Coordinators (2015) Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure. Circulation 131(1):54–61 CrossRefPubMed Packer M, McMurray JJ, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile M, Andersen K, Arango JL, Arnold JM, Bělohlávek J, Böhm M, Boytsov S, Burgess LJ, Cabrera W, Calvo C, Chen CH, Dukat A, Duarte YC, Erglis A, Fu M, Gomez E, Gonzàlez-Medina A, Hagège AA, Huang J, Katova T, Kiatchoosakun S, Kim KS, Kozan Ö, Llamas EB, Martinez F, Merkely B, Mendoza I, Mosterd A, Negrusz-Kawecka M, Peuhkurinen K, Ramires FJ, Refsgaard J, Rosenthal A, Senni M, Sibulo AS Jr, Silva-Cardoso J, Squire IB, Starling RC, Teerlink JR, Vanhaecke J, Vinereanu D, Wong RC, PARADIGM-HF Investigators and Coordinators (2015) Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure. Circulation 131(1):54–61 CrossRefPubMed
31.
Zurück zum Zitat Davis M, Espiner E, Richards G, Billings J, Town I, Neill A, Drennan C, Richards M, Turner J, Yandle T (1994) Plasma brain natriuretic peptide in assessment of acute dyspnoea. Lancet 343(8895):440–444 CrossRefPubMed Davis M, Espiner E, Richards G, Billings J, Town I, Neill A, Drennan C, Richards M, Turner J, Yandle T (1994) Plasma brain natriuretic peptide in assessment of acute dyspnoea. Lancet 343(8895):440–444 CrossRefPubMed
32.
Zurück zum Zitat Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, Omland T, Storrow AB, Abraham WT, Wu AH, Clopton P, Steg PG, Westheim A, Knudsen CW, Perez A, Kazanegra R, Herrmann HC, McCullough PA, Breathing Not Properly Multinational Study Investigators (2002) Rapid measurement of B‑type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347(3):161–167 CrossRefPubMed Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, Omland T, Storrow AB, Abraham WT, Wu AH, Clopton P, Steg PG, Westheim A, Knudsen CW, Perez A, Kazanegra R, Herrmann HC, McCullough PA, Breathing Not Properly Multinational Study Investigators (2002) Rapid measurement of B‑type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 347(3):161–167 CrossRefPubMed
33.
Zurück zum Zitat Mueller C, Scholer A, Laule-Kilian K, Martina B, Schindler C, Buser P, Pfisterer M, Perruchoud AP (2004) Use of B‑type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 350(7):647–654 CrossRefPubMed Mueller C, Scholer A, Laule-Kilian K, Martina B, Schindler C, Buser P, Pfisterer M, Perruchoud AP (2004) Use of B‑type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 350(7):647–654 CrossRefPubMed
34.
Zurück zum Zitat Januzzi JL Jr, Camargo CA, Anwaruddin S, Baggish AL, Chen AA, Krauser DG, Tung R, Cameron R, Nagurney JT, Chae CU, Lloyd-Jones DM, Brown DF, Foran-Melanson S, Sluss PM, Lee-Lewandrowski E, Lewandrowski KB (2005) The N‑terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol 95(8):948–954 CrossRefPubMed Januzzi JL Jr, Camargo CA, Anwaruddin S, Baggish AL, Chen AA, Krauser DG, Tung R, Cameron R, Nagurney JT, Chae CU, Lloyd-Jones DM, Brown DF, Foran-Melanson S, Sluss PM, Lee-Lewandrowski E, Lewandrowski KB (2005) The N‑terminal Pro-BNP investigation of dyspnea in the emergency department (PRIDE) study. Am J Cardiol 95(8):948–954 CrossRefPubMed
35.
Zurück zum Zitat Fonarow GC, Peacock WF, Phillips CO, Givertz MM, Lopatin M, ADHERE Scientific Advisory Committee and Investigators (2007) Admission B‑type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure. J Am Coll Cardiol 49(19):1943–1950 CrossRefPubMed Fonarow GC, Peacock WF, Phillips CO, Givertz MM, Lopatin M, ADHERE Scientific Advisory Committee and Investigators (2007) Admission B‑type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure. J Am Coll Cardiol 49(19):1943–1950 CrossRefPubMed
36.
Zurück zum Zitat Januzzi JL Jr, Sakhuja R, O’donoghue M, Baggish AL, Anwaruddin S, Chae CU, Cameron R, Krauser DG, Tung R, Camargo CA Jr, Lloyd-Jones DM (2006) Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1‑year mortality in patients with dyspnea treated in the emergency department. Arch Intern Med 166(3):315–320 CrossRefPubMed Januzzi JL Jr, Sakhuja R, O’donoghue M, Baggish AL, Anwaruddin S, Chae CU, Cameron R, Krauser DG, Tung R, Camargo CA Jr, Lloyd-Jones DM (2006) Utility of amino-terminal pro-brain natriuretic peptide testing for prediction of 1‑year mortality in patients with dyspnea treated in the emergency department. Arch Intern Med 166(3):315–320 CrossRefPubMed
37.
Zurück zum Zitat Logeart D, Thabut G, Jourdain P, Chavelas C, Beyne P, Beauvais F, Bouvier E, Solal AC (2004) Predischarge B‑type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure. J Am Coll Cardiol 43(4):635–641 CrossRefPubMed Logeart D, Thabut G, Jourdain P, Chavelas C, Beyne P, Beauvais F, Bouvier E, Solal AC (2004) Predischarge B‑type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure. J Am Coll Cardiol 43(4):635–641 CrossRefPubMed
38.
Zurück zum Zitat Bettencourt P, Azevedo A, Pimenta J, Friões F, Ferreira S, Ferreira A (2004) N‑terminal-pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients. Circulation 110(15):2168–2174 CrossRefPubMed Bettencourt P, Azevedo A, Pimenta J, Friões F, Ferreira S, Ferreira A (2004) N‑terminal-pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients. Circulation 110(15):2168–2174 CrossRefPubMed
39.
Zurück zum Zitat van Kimmenade RR, Januzzi JL Jr, Ellinor PT, Sharma UC, Bakker JA, Low AF, Martinez A, Crijns HJ, MacRae CA, Menheere PP, Pinto YM (2006) Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol 48(6):1217–1224 CrossRefPubMed van Kimmenade RR, Januzzi JL Jr, Ellinor PT, Sharma UC, Bakker JA, Low AF, Martinez A, Crijns HJ, MacRae CA, Menheere PP, Pinto YM (2006) Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol 48(6):1217–1224 CrossRefPubMed
40.
Zurück zum Zitat Bolignano D, Cabassi A, Fiaccadori E, Ghigo E, Pasquali R, Peracino A, Peri A, Plebani M, Santoro A, Settanni F, Zoccali C (2014) Copeptin (CTproAVP), a new tool for understanding the role of vasopressin in pathophysiology. Clin Chem Lab Med 52(10):1447–1456 CrossRefPubMed Bolignano D, Cabassi A, Fiaccadori E, Ghigo E, Pasquali R, Peracino A, Peri A, Plebani M, Santoro A, Settanni F, Zoccali C (2014) Copeptin (CTproAVP), a new tool for understanding the role of vasopressin in pathophysiology. Clin Chem Lab Med 52(10):1447–1456 CrossRefPubMed
41.
Zurück zum Zitat Morgenthaler NG (2010) Copeptin: a biomarker of cardiovascular and renal function. Congest Heart Fail 16(Suppl 1):S37–S44 CrossRefPubMed Morgenthaler NG (2010) Copeptin: a biomarker of cardiovascular and renal function. Congest Heart Fail 16(Suppl 1):S37–S44 CrossRefPubMed
42.
Zurück zum Zitat Liebetrau C, Nef H, Szardien S, Dörr O, Willmer M, Voss S, Troidl C, Hoffmann J, Rixe J, Rolf A, Hamm C, Möllmann H (2013) Release kinetics of copeptin in patients undergoing transcoronary ablation of septal hypertrophy. Clin Chem 59(3):566–569 CrossRefPubMed Liebetrau C, Nef H, Szardien S, Dörr O, Willmer M, Voss S, Troidl C, Hoffmann J, Rixe J, Rolf A, Hamm C, Möllmann H (2013) Release kinetics of copeptin in patients undergoing transcoronary ablation of septal hypertrophy. Clin Chem 59(3):566–569 CrossRefPubMed
43.
Zurück zum Zitat Reichlin T, Hochholzer W, Stelzig C, Laule K, Freidank H, Morgenthaler NG, Bergmann A, Potocki M, Noveanu M, Breidthardt T, Christ A, Boldanova T, Merki R, Schaub N, Bingisser R, Christ M, Mueller C (2009) Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol 54(1):60–68 CrossRef Reichlin T, Hochholzer W, Stelzig C, Laule K, Freidank H, Morgenthaler NG, Bergmann A, Potocki M, Noveanu M, Breidthardt T, Christ A, Boldanova T, Merki R, Schaub N, Bingisser R, Christ M, Mueller C (2009) Incremental value of copeptin for rapid rule out of acute myocardial infarction. J Am Coll Cardiol 54(1):60–68 CrossRef
44.
Zurück zum Zitat Maisel A, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke G, Daniels LB, Hollander JE, Apple FS, Cannon C, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Stein JC, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Papassotiriou J, Hartmann O, Ebmeyer S, Clopton P, Jaffe AS, Peacock WF (2013) Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction). J Am Coll Cardiol 62(2):150–160 CrossRefPubMed Maisel A, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke G, Daniels LB, Hollander JE, Apple FS, Cannon C, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Stein JC, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Papassotiriou J, Hartmann O, Ebmeyer S, Clopton P, Jaffe AS, Peacock WF (2013) Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection Of Patients with acute myocardial INfarction). J Am Coll Cardiol 62(2):150–160 CrossRefPubMed
45.
Zurück zum Zitat Khan SQ, Dhillon OS, O’Brien RJ, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL (2007) C‑terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation 115(16):2103–2110 CrossRef Khan SQ, Dhillon OS, O’Brien RJ, Struck J, Quinn PA, Morgenthaler NG, Squire IB, Davies JE, Bergmann A, Ng LL (2007) C‑terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation 115(16):2103–2110 CrossRef
46.
Zurück zum Zitat Morgenthaler NG, Müller B, Struck J, Bergmann A, Redl H, Christ-Crain M (2007) Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock. Shock 28(2):219–226 CrossRefPubMed Morgenthaler NG, Müller B, Struck J, Bergmann A, Redl H, Christ-Crain M (2007) Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock. Shock 28(2):219–226 CrossRefPubMed
47.
Zurück zum Zitat Hellenkamp K, Schwung J, Rossmann H, Kaeberich A, Wachter R, Hasenfuß G, Konstantinides S, Lankeit M (2015) Risk stratification of normotensive pulmonary embolism: prognostic impact of copeptin. Eur Respir J 46(6):1701–1710 CrossRefPubMed Hellenkamp K, Schwung J, Rossmann H, Kaeberich A, Wachter R, Hasenfuß G, Konstantinides S, Lankeit M (2015) Risk stratification of normotensive pulmonary embolism: prognostic impact of copeptin. Eur Respir J 46(6):1701–1710 CrossRefPubMed
49.
Zurück zum Zitat Maisel A, Xue Y, Shah K, Mueller C, Nowak R, Peacock WF, Ponikowski P, Mockel M, Hogan C, Wu AH, Richards M, Clopton P, Filippatos GS, Di Somma S, Anand IS, Ng L, Daniels LB, Neath SX, Christenson R, Potocki M, McCord J, Terracciano G, Kremastinos D, Hartmann O, von Haehling S, Bergmann A, Morgenthaler NG, Anker SD (2011) Increased 90-day mortality in patients with acute heart failure with elevated copeptin: secondary results from the Biomarkers in Acute Heart Failure (BACH) study. Circ Heart Fail 4(5):613–620 CrossRefPubMed Maisel A, Xue Y, Shah K, Mueller C, Nowak R, Peacock WF, Ponikowski P, Mockel M, Hogan C, Wu AH, Richards M, Clopton P, Filippatos GS, Di Somma S, Anand IS, Ng L, Daniels LB, Neath SX, Christenson R, Potocki M, McCord J, Terracciano G, Kremastinos D, Hartmann O, von Haehling S, Bergmann A, Morgenthaler NG, Anker SD (2011) Increased 90-day mortality in patients with acute heart failure with elevated copeptin: secondary results from the Biomarkers in Acute Heart Failure (BACH) study. Circ Heart Fail 4(5):613–620 CrossRefPubMed
50.
Zurück zum Zitat Düngen HD, Tscholl V, Obradovic D, Radenovic S, Matic D, Musial Bright L, Tahirovic E, Marx A, Inkrot S, Hashemi D, Veskovic J, Apostolovic S, von Haehling S, Doehner W, Cvetinovic N, Lainscak M, Pieske B, Edelmann F, Trippel T, Loncar G (2018) Prognostic performance of serial in-hospital measurements of copeptin and multiple novel biomarkers among patients with worsening heart failure: results from the MOLITOR study. Esc Heart Fail 5(2):288–296 CrossRefPubMedPubMedCentral Düngen HD, Tscholl V, Obradovic D, Radenovic S, Matic D, Musial Bright L, Tahirovic E, Marx A, Inkrot S, Hashemi D, Veskovic J, Apostolovic S, von Haehling S, Doehner W, Cvetinovic N, Lainscak M, Pieske B, Edelmann F, Trippel T, Loncar G (2018) Prognostic performance of serial in-hospital measurements of copeptin and multiple novel biomarkers among patients with worsening heart failure: results from the MOLITOR study. Esc Heart Fail 5(2):288–296 CrossRefPubMedPubMedCentral
51.
Zurück zum Zitat Statistisches Bundesamt (Destatis) (2017) Fallpauschalenbezogene Krankenhausstatistik 2016. Fachserie 12 Reihe 6.4. Statistisches Bundesamt (Destatis) (2017) Fallpauschalenbezogene Krankenhausstatistik 2016. Fachserie 12 Reihe 6.4.
52.
Zurück zum Zitat Hummel A, Empe K, Dörr M, Felix SB (2015) De novo acute heart failure and acutely decompensated chronic heart failure. Dtsch Arztebl Int 112(17):298–310 PubMedPubMedCentral Hummel A, Empe K, Dörr M, Felix SB (2015) De novo acute heart failure and acutely decompensated chronic heart failure. Dtsch Arztebl Int 112(17):298–310 PubMedPubMedCentral
53.
Zurück zum Zitat Luchner A, von Haehling S, Holubarsch C, Keller T, Knebel F, Zugck C, Laufs U (2017) Einsatzgebiete und praktischer Nutzen der kardialen Marker BNP und NT-proBNP. Dtsch Med Wochenschr 142(5):346–355 CrossRefPubMed Luchner A, von Haehling S, Holubarsch C, Keller T, Knebel F, Zugck C, Laufs U (2017) Einsatzgebiete und praktischer Nutzen der kardialen Marker BNP und NT-proBNP. Dtsch Med Wochenschr 142(5):346–355 CrossRefPubMed
54.
Zurück zum Zitat Kube J, Ebner N, Jankowska EA, Rozentryt P, Cicoira M, Filippatos GS, Ponikowski P, Doehner W, Anker SD, von Haehling S (2016) The influence of confounders in the analysis of mid-regional pro-atrial natriuretic peptide in patients with chronic heart failure. Int J Cardiol 219:84–91 CrossRefPubMed Kube J, Ebner N, Jankowska EA, Rozentryt P, Cicoira M, Filippatos GS, Ponikowski P, Doehner W, Anker SD, von Haehling S (2016) The influence of confounders in the analysis of mid-regional pro-atrial natriuretic peptide in patients with chronic heart failure. Int J Cardiol 219:84–91 CrossRefPubMed
Metadaten
Titel
Bedeutung von Biomarkern bei akuter Herzinsuffizienz
verfasst von
Dr. Kristian Hellenkamp
Univ.-Prof. DDr. Stephan von Haehling
Publikationsdatum
07.08.2019
Verlag
Springer Vienna
Schlagwort
Kardiologie
Erschienen in
Wiener klinisches Magazin / Ausgabe 4/2019
Print ISSN: 1869-1757
Elektronische ISSN: 1613-7817
DOI
https://doi.org/10.1007/s00740-019-00299-z