Several trials have investigated the effect of novel neoadjuvant regimens on the resectability of both borderline resectable (BR) and locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). However, specific histopathologic changes of PDAC …
Hilar cholangiocarcinoma (HCCA) is a malignant tumour arising from the confluence of the common hepatic duct into left and right branches. Pathologically, HCCA is known to spread longitudinally along the bile ducts, with concomitant perineural …
Autoren:
MB ChB, MRes Dr. Abdullah Khalid Malik, MB ChB, PhD Stuart Michael Robinson, MB BS, MD Jeremy Jules French, MB BS, MD Gourab Sen, MB BS, PhD Colin Hugh Wilson, BM BS, PhD John Stotesbury Hammond, MB ChB, MD Prof. Steven Alan White, MB BCh, MMed Prof. Derek Michael Manas
The oncologists view: systemic treatment options in 2018
Ductal pancreatic cancer currently represents the seventh most common cause of cancer mortality worldwide, accounting for about 4% of cancer-related deaths in males and females [ 1 ]. It is more common in the elderly population and rarely diagnosed …
Autoren:
Angela Djanani, Andreas Schmiderer, Lukas Niederreiter, Markus Niederreiter, Herbert Tilg
Kehlet et al. introduced the enhanced recovery after surgery (ERAS) protocol for perioperative care in 1997 as a way to accelerate recovery after surgery [ 1 ]. This protocol has been shown in various randomised controlled clinical trials …
Autoren:
M.D. Ph.D. Petr Kocián, M.D. Adam Whitley, M.D. Petr Přikryl, M.D. Markéta Bocková, M.D. Ph.D. Daniel Hodyc, M.Phil. Blanka Čermáková, M.D. Ph.D. Tomáš Vymazal, M.D. Ph.D. Jiří Hoch
The manifestation of an echinococcus multilocularis (EM) infection, known as alveolar echinococcosis (AE), represents a highly pathogenic and potentially deadly disease of visceral organs. The natural course consists of an asymptomatic incubation …
Autoren:
Stefanie Kuscher, Irmgard Elisabeth Kronberger, Alexander Loizides, Michaela Plaikner, Marijana Ninkovic, Andrea Brunner, Herbert Auer, Eva Maria Gassner, Dietmar Öfner, Stefan Schneeberger
Three decades ago, cystic neoplasia of the pancreas were a relatively unknown and poorly classified tumor entity. Nowadays, they account for a large proportion of treated lesions in the field of pancreatic surgery. The development of …
Autoren:
Assoc. Prof. PD Dr. Klaus Sahora, Univ. Prof. Dr. Martin Schindl
Chronic pancreatitis (CP) remains a challenging condition to manage, despite its establishment as a clinical entity almost 80 years ago [ 1 ]. Although most studies demonstrate incidence and prevalence rates of around 7 per 100,000 and 28 per …
Autoren:
Carlo Frola, Murali Somasundaram, Deepak Hariharan, Valdone Kolaityte, Shailesh Mohandas, PD Dr. Stefan Stättner, Vincent S. Yip
An internal hernia is defined as a protrusion from the intestines or other abdominal organs through a congenital (for example omental foramen) or acquired (post-surgery, post-traumatic, post-infection) aperture within the peritoneal cavity.
Autoren:
Jan Philipp Ramspott, MD Tarkan Jäger, Klaus Emmanuel, Philipp Schredl
In the recent issues of European Surgery we examined how much myth, medicine, surgery, diagnosis, therapy, and the conduct of disease management share a common character and quality. Basically, myth and medicine operate by converting images …
Stenosis of the carotid artery is considered to be the foremost cause of stroke. The indications for CEA to prevent stroke in symptomatic and asymptomatic patients are well known, while is uncertain in octogenarians. The incidence of carotid …
Autoren:
MD Serkan Burç Deşer, MD Mustafa Kemal Demirag, MD Fersat Kolbakir, MD Semih Murat Yucel, MD Murat Muzaffer Güçlü, MD Merve Polat, MD Hasan Tahsin Keceligil
The technical and clinical progress in surgery of the pancreas has led to an advancement regarding resectability of pancreatic pathologies over the past decades [ 1 ]. Pancreaticoduodenectomy and total pancreatectomy are performed in a higher …
Autoren:
Daniel Putzer, Peter Schullian, Stefan Stättner, Florian Primavesi, Eva Braunwarth, Margot Fodor, Benno Cardini, Thomas Resch, Rupert Oberhuber, Manuel Maglione, Christian Margreiter, Stefan Schneeberger, Dietmar Öfner, Reto Bale, Werner Jaschke
Despite enormous efforts and improvements in terms of effective chemotherapy regimens as well as the perioperative and surgical management of patients with pancreatic cancer (PC; [ 1 – 4 ]), the prognosis for the whole cohort suffering from this …
Autoren:
Willem Niesen, Florian Primavesi, Silvia Gasteiger, John Neoptolemos, Thilo Hackert, PD Dr. Stefan Stättner
Frailty is a complex concept which has received several definitions over the years. Initially, a biological syndrome was considered to be characterized by a decrease in homeostasis and resistance to stress, in which vulnerability and disability …
Pancreatic cancer is presently the third leading cause of cancer-related death in the Western world and is projected to become the second leading cause of cancer-related mortality within the next few years [ 1 , 2 ]. For all stages combined, the …
Autoren:
Ulla Klaiber, Susanne Roth, Thilo Hackert, MA, MB, BChir, MD, FRCS, FMedSci John P. Neoptolemos
Esophageal cancer (EC) represents a significant global health burden with 746,000 new cases and 459,300 deaths reported in 2015 [ 1 , 2 ]. The incidence of EC is rising worldwide, mainly due to the increased incidence rates of adenocarcinoma of the …
Autoren:
MD Assistant Professor Dejan Velickovic, MD, PhD Associate Professor Predrag Sabljak, MD, PhD Associate Professor Dejan Stojakov, MD Assistant Professor Jelena Velickovic, MD, PhD Assistant Professor Keramatollah Ebrahimi, MD Assistant Professor Vladimir Sljukic, MD, PhD, FACS Professor Predrag Pesko
Anastomotic leakage (AL) following colorectal surgery represents a devastating postoperative complication with an incidence ranging from 3 to 39% [ 1 , 2 ]. Early healing is dependent upon suture (or staple) integrity with an appropriate degree of …
Autoren:
MD FEBS Bernhard Dauser, MD Wolf Heitland, MD Franz G. Bader, MSc FRCS Walter Brunner, MD Yael Nir, MD (Lond) MBBS (Melb) FRCS (Ed) FRACS FSICCR (Hon) Andrew P. Zbar
Mortality following pancreatic resection (PR) has decreased over the last decades with current rates ranging between 2 and 6% in high-volume centres. In contrast, morbidity in this surgical field still remains high, and increases depending on the …
Autoren:
Benno Cardini, MD Florian Primavesi, Manuel Maglione, Julia Oberschmied, Luisa Guschlbauer, Silvia Gasteiger, Stefanie Kuscher, Thomas Resch, Rupert Oberhuber, Christian Margreiter, Stefan Schneeberger, Dietmar Öfner, Stefan Stättner
Blunt abdominal injuries, frequently due to sports and traffic accidents, represent a challenging and common cause of trauma in central Europe. Management of these injuries can be difficult because of the frequent association with a multifaceted …
Autoren:
Margot Fodor, Florian Primavesi, Dagmar Morell-Hofert, Matthias Haselbacher, Eva Braunwarth, Benno Cardini, Eva Gassner, Dietmar Öfner, MD Stefan Stättner
The liver is the most common site for distant metastatic spread of rectal cancer [ 1 ]. In patients with liver metastases, approximately 20% will present with synchronous disease [ 2 ]. Liver resection of colorectal metastases has been shown to …
Autoren:
Andrew E. Giles, Marlie Valencia, Sameer Parpia, Erin Fu, Leyo Ruo, Marko Simunovic, Dr. Pablo E. Serrano
Despite an ongoing significant improvement of perioperative mortality during the past years, pancreatoduodenectomy still remains a challenging procedure. This is reflected in institutional and national series demonstrating a 30-day mortality of up …
Autoren:
Helwig Wundsam, Christiane S. Rösch, Ines Fischer, Reinhold Függer