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Erschienen in: Wiener Medizinische Wochenschrift 13-14/2016

01.10.2016 | main topic

Iron, microbiota and colorectal cancer

verfasst von: Oliver Ng

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 13-14/2016

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Summary

Iron deficiency and anaemia are common in colorectal cancer. Replacement with oral or intravenous iron effectively treats this deficiency. However, mechanistic and population studies suggest that excess iron promotes colorectal carcinogenesis. Growing research into gut microbiota and dysbiosis suggests one explanation for this association. Iron is growth limiting for many pathogenic bacteria and may promote a shift in the ratio of pathogenic to protective bacteria. This may increase the toxic bacterial metabolites, promoting inflammation and carcinogenesis. This has important implications as we seek to correct anaemia in our patients.
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Metadaten
Titel
Iron, microbiota and colorectal cancer
verfasst von
Oliver Ng
Publikationsdatum
01.10.2016
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 13-14/2016
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-016-0508-4