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01.10.2016 | main topic

Iron, microbiota and colorectal cancer

verfasst von: Oliver Ng

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 13-14/2016

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Summary

Iron deficiency and anaemia are common in colorectal cancer. Replacement with oral or intravenous iron effectively treats this deficiency. However, mechanistic and population studies suggest that excess iron promotes colorectal carcinogenesis. Growing research into gut microbiota and dysbiosis suggests one explanation for this association. Iron is growth limiting for many pathogenic bacteria and may promote a shift in the ratio of pathogenic to protective bacteria. This may increase the toxic bacterial metabolites, promoting inflammation and carcinogenesis. This has important implications as we seek to correct anaemia in our patients.

Vorheriger Artikel Autoimmune gastritis

Nächster Artikel Eisenmangel, Thrombozytose und Thromboembolie

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Titel: Iron, microbiota and colorectal cancer
verfasst von: Oliver Ng
Publikationsdatum: 01.10.2016
Verlag: Springer Vienna
Erschienen in: Wiener Medizinische Wochenschrift / Ausgabe 13-14/2016
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI: https://doi.org/10.1007/s10354-016-0508-4

Springer Medizin Österreich

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