Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Wiener klinische Wochenschrift 1-2/2022

24.11.2021 | original article

Impact of rapid correction of vitamin D deficiency in asthmatic patients

verfasst von: PharmD Dr. Ariandokht Einisadr, Ph.D. Dr. Mehdi Rajabi, M.D. Dr. Hamidreza Moezzi, M.D. Ph.D. Dr. Hooman Bakhshandeh

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2022

Einloggen, um Zugang zu erhalten
share
TEILEN

Summary

Background

Asthma is one of the most common chronic diseases, which is a growing public health concern worldwide. In recent years, there has been an increasing number of interests in the relationship between vitamin D level and asthma control. Hence, the objective of this study was to assess the effect of high doses of vitamin D3 injection on asthmatic patient’s respiratory condition and quality of life.

Methods

This was a single arm, before and after interventional study involving 18 patients with moderate to severe asthma. Spirometry test, St George’s respiratory questionnaire (SGRQ) and serum vitamin D assay were performed. Subjects with 25-hydroxyvitamin D3 (25-(OH) D3) < 20 ng/ml were deemed deficient (n = 18) and received 2 intramuscular injections of vitamin D3 300,000 IU at monthly intervals consecutively.

Results

The mean changes of forced expiratory volume in the first second (FEV1) were significantly different in subjects who received vitamin D3 injections (p = 0.008). Also, the mean changes in FEV1/forced vital capacity ratio (FEV1/FVC) were significant (p < 0.001) as well as maximum expiratory flow between 25% and 75% of FVC (MEF25-75) (p = 0.001). Interestingly, improvement in clinical parameters of SGRQ was also observed with significant differences in total score (p = 0.001). Naturally, serum vitamin D levels were increased in our patients following the injections (p < 0.001).

Conclusions

Our findings suggest that screening for serum 25-(OH) D3 deficiency is important in asthmatic patients and correction of this deficiency with high doses of vitamin D3 injection may lead to improvement in pulmonary function, symptoms and quality of life (QOL).
Literatur
1.
Zurück zum Zitat Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 1: a review of potential mechanisms. Pulm Pharmacol Ther. 2015;32:60–74. CrossRef Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 1: a review of potential mechanisms. Pulm Pharmacol Ther. 2015;32:60–74. CrossRef
2.
Zurück zum Zitat Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014;371(13):1189–97. CrossRef Bel EH, Wenzel SE, Thompson PJ, Prazma CM, Keene ON, Yancey SW, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014;371(13):1189–97. CrossRef
3.
Zurück zum Zitat Mohamed AS, Ibrahim IS, Ibrahim WS. Serum vitamin D levels in patients with atopic asthma. Egypt J Chest Dis Tuberc. 2015;64(2):303–6. CrossRef Mohamed AS, Ibrahim IS, Ibrahim WS. Serum vitamin D levels in patients with atopic asthma. Egypt J Chest Dis Tuberc. 2015;64(2):303–6. CrossRef
4.
Zurück zum Zitat Litonjua AA. Vitamin D deficiency as a risk factor for childhood allergic disease and asthma. Curr Opin Allergy Clin Immunol. 2012;12(2):179. CrossRef Litonjua AA. Vitamin D deficiency as a risk factor for childhood allergic disease and asthma. Curr Opin Allergy Clin Immunol. 2012;12(2):179. CrossRef
5.
Zurück zum Zitat Bener A, Ehlayel MS, Tulic MK, Hamid Q. Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol. 2012;157(2):168–75. CrossRef Bener A, Ehlayel MS, Tulic MK, Hamid Q. Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol. 2012;157(2):168–75. CrossRef
6.
Zurück zum Zitat Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 2011;158(3):437–41. CrossRef Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 2011;158(3):437–41. CrossRef
7.
Zurück zum Zitat Sharif MR, Tabatabaei F, Madani M. The relationship between serum vitamin D levels and asthma in children referred to the pediatric clinics in Isfahan during 2012–2013. KAUMS J. 2014;18(5):462–8. Sharif MR, Tabatabaei F, Madani M. The relationship between serum vitamin D levels and asthma in children referred to the pediatric clinics in Isfahan during 2012–2013. KAUMS J. 2014;18(5):462–8.
8.
Zurück zum Zitat Korn S, Hübner M, Jung M, Blettner M, Buhl R. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res. 2013;14(1):25. CrossRef Korn S, Hübner M, Jung M, Blettner M, Buhl R. Severe and uncontrolled adult asthma is associated with vitamin D insufficiency and deficiency. Respir Res. 2013;14(1):25. CrossRef
9.
Zurück zum Zitat Hollams EM, Hart PH, Holt BJ, Serralha M, Parsons F, De Klerk NH, et al. Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study. Eur Respir J. 2011;38(6):1320–7. CrossRef Hollams EM, Hart PH, Holt BJ, Serralha M, Parsons F, De Klerk NH, et al. Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study. Eur Respir J. 2011;38(6):1320–7. CrossRef
10.
Zurück zum Zitat Rajabbik MH, Lotfi T, Alkhaled L, Fares M, Fuleihan GE, Mroueh S, et al. Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy Asthma Clin Immunol. 2014;10(1):31. CrossRef Rajabbik MH, Lotfi T, Alkhaled L, Fares M, Fuleihan GE, Mroueh S, et al. Association between low vitamin D levels and the diagnosis of asthma in children: a systematic review of cohort studies. Allergy Asthma Clin Immunol. 2014;10(1):31. CrossRef
11.
Zurück zum Zitat Paul G, Brehm JM, Alcorn JF, Holguín F, Aujla SJ, Celedón JC. Vitamin D and asthma. Am J Respir Crit Care Med. 2012;185(2):124–32. CrossRef Paul G, Brehm JM, Alcorn JF, Holguín F, Aujla SJ, Celedón JC. Vitamin D and asthma. Am J Respir Crit Care Med. 2012;185(2):124–32. CrossRef
12.
Zurück zum Zitat Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol. 2010;105(3):191–9. CrossRef Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol. 2010;105(3):191–9. CrossRef
13.
Zurück zum Zitat Mendy A, Cohn RD, Thorne PS. Endotoxin exposure, serum vitamin D, asthma and wheeze outcomes. Respir Med. 2016;114:61–6. CrossRef Mendy A, Cohn RD, Thorne PS. Endotoxin exposure, serum vitamin D, asthma and wheeze outcomes. Respir Med. 2016;114:61–6. CrossRef
14.
Zurück zum Zitat Samaha HM, Elsaid AR, NasrEldin E. Vitamin D and markers of airway inflammation in asthma. Egypt J Chest Dis Tuberc. 2015;64(4):779–83. CrossRef Samaha HM, Elsaid AR, NasrEldin E. Vitamin D and markers of airway inflammation in asthma. Egypt J Chest Dis Tuberc. 2015;64(4):779–83. CrossRef
15.
Zurück zum Zitat Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med. 2011;184(12):1342–9. CrossRef Gupta A, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med. 2011;184(12):1342–9. CrossRef
16.
Zurück zum Zitat Gupta A, Bhat G, Pianosi P. What is new in the management of childhood asthma? Indian J Pediatr. 2018;85(9):773–81. CrossRef Gupta A, Bhat G, Pianosi P. What is new in the management of childhood asthma? Indian J Pediatr. 2018;85(9):773–81. CrossRef
17.
Zurück zum Zitat Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 2010;126(1):52–8. CrossRef Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 2010;126(1):52–8. CrossRef
18.
Zurück zum Zitat Raissy H, Blake K. Vitamin D and asthma: association, causality, or intervention? Pediatr Allergy Immunol Pulmonol. 2015;28(1):60–2. CrossRef Raissy H, Blake K. Vitamin D and asthma: association, causality, or intervention? Pediatr Allergy Immunol Pulmonol. 2015;28(1):60–2. CrossRef
19.
Zurück zum Zitat Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med. 2010;181(7):699–704. CrossRef Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med. 2010;181(7):699–704. CrossRef
20.
Zurück zum Zitat Columbo M, Panettieri RA, Rohr AS. Asthma in the elderly: a study of the role of vitamin D. Allergy Asthma Clin Immunol. 2014;10(1):48. CrossRef Columbo M, Panettieri RA, Rohr AS. Asthma in the elderly: a study of the role of vitamin D. Allergy Asthma Clin Immunol. 2014;10(1):48. CrossRef
21.
Zurück zum Zitat Gouda E, Zidan M, Gharraf H, Younan DN, Mohamed S. Pattern of vitamin D in patients with chronic obstructive pulmonary diseases and in patients with bronchial asthma. Egypt J Chest Dis Tuberc. 2016;65(2):389–96. CrossRef Gouda E, Zidan M, Gharraf H, Younan DN, Mohamed S. Pattern of vitamin D in patients with chronic obstructive pulmonary diseases and in patients with bronchial asthma. Egypt J Chest Dis Tuberc. 2016;65(2):389–96. CrossRef
22.
Zurück zum Zitat Yadav M, Mittal K. Effect of vitamin D supplementation on moderate to severe bronchial asthma. Indian J Pediatr. 2014;81(7):650–4. CrossRef Yadav M, Mittal K. Effect of vitamin D supplementation on moderate to severe bronchial asthma. Indian J Pediatr. 2014;81(7):650–4. CrossRef
23.
Zurück zum Zitat Pojsupap S, Iliriani K, Sampaio TZ, O’Hearn K, Kovesi T, Menon K, et al. Efficacy of high-dose vitamin D in pediatric asthma: a systematic review and meta-analysis. J Asthma. 2015;52(4):382–90. CrossRef Pojsupap S, Iliriani K, Sampaio TZ, O’Hearn K, Kovesi T, Menon K, et al. Efficacy of high-dose vitamin D in pediatric asthma: a systematic review and meta-analysis. J Asthma. 2015;52(4):382–90. CrossRef
24.
Zurück zum Zitat de Groot JC, van Roon EN, Storm H, Veeger NJ, Zwinderman AH, Hiemstra PS, et al. Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma. J Allergy Clin Immunol. 2015;135(3):670–5. CrossRef de Groot JC, van Roon EN, Storm H, Veeger NJ, Zwinderman AH, Hiemstra PS, et al. Vitamin D reduces eosinophilic airway inflammation in nonatopic asthma. J Allergy Clin Immunol. 2015;135(3):670–5. CrossRef
25.
Zurück zum Zitat Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311(20):2083–91. CrossRef Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014;311(20):2083–91. CrossRef
26.
Zurück zum Zitat Razavi MZ, Nazarali P, Hanachi P. The effect of an exercise programme and consumption of vitamin D on performance and respiratory indicators in patients with asthma. Sport Sci Health. 2011;6(2–3):89. CrossRef Razavi MZ, Nazarali P, Hanachi P. The effect of an exercise programme and consumption of vitamin D on performance and respiratory indicators in patients with asthma. Sport Sci Health. 2011;6(2–3):89. CrossRef
Metadaten
Titel
Impact of rapid correction of vitamin D deficiency in asthmatic patients
verfasst von
PharmD Dr. Ariandokht Einisadr
Ph.D. Dr. Mehdi Rajabi
M.D. Dr. Hamidreza Moezzi
M.D. Ph.D. Dr. Hooman Bakhshandeh
Publikationsdatum
24.11.2021
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2022
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-021-01975-z