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Erschienen in: Wiener klinische Wochenschrift 9-10/2019

18.03.2019 | consensus statement

Contralateral prophylactic mastectomy in women with breast cancer without a family history or genetic predisposition

Consensus statement from the Austrian Gynecologic Oncology Working Group of the Austrian Society of Obstetrics and Gynecology

verfasst von: Vesna Bjelic-Radisic, MD, Christian Singer, Karl Tamussino, Heinz Kölbl, Edgar Petru, Birgit Volgger, Stephan Polterauer, Peter Oppelt, Paul Sevelda, Gerhard Bogner, Christian Marth, Austrian Gynecologic Oncology Working Group

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2019

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Summary

The working group recommends against contralateral prophylactic mastectomy (CPM) in women with breast cancer without a family history or genetic predisposition with unilateral breast cancer. This is based on the low risk of developing contralateral breast cancer, the lack of a survival benefit, the increased risk of surgical complications, and the lack of benefit on quality of life.
Fußnoten
1
Bilateral breast cancer counts for two cases of breast cancer.
 
2
Bilateral breast cancer counts for two cases of breast cancer.
 
3
This recommendation is also pertinent to patients with cancer of the fallopian tube and primary peritoneal cancer.
 
Literatur
1.
Zurück zum Zitat Boughey JC, Attai DJ, Chen SL, et al. Contralateral prophylactic mastectomy (CPM) consensus statement from the American Society of Breast Surgeons: Data on CPM Outcomes and Risks. Ann Surg Oncol. 2016;23:3100–5.CrossRef Boughey JC, Attai DJ, Chen SL, et al. Contralateral prophylactic mastectomy (CPM) consensus statement from the American Society of Breast Surgeons: Data on CPM Outcomes and Risks. Ann Surg Oncol. 2016;23:3100–5.CrossRef
2.
Zurück zum Zitat Pesce CE, Liederbach E, Czechura T, et al. Changig surgical trends in young patients with early stage breast cancer, 2003–2010: A report from the National Cancer Data base. J Am Coll Surg. 2014;219:19–30.CrossRef Pesce CE, Liederbach E, Czechura T, et al. Changig surgical trends in young patients with early stage breast cancer, 2003–2010: A report from the National Cancer Data base. J Am Coll Surg. 2014;219:19–30.CrossRef
3.
Zurück zum Zitat Singer CF, Tea MK, Pristauz G, et al. Clinical Practice Guideline for the prevention and early detection of breast and ovarian cancer in women from HBOC (hereditary breast and ovarian cancer) families. Wien Klin Wochenschr. 2015;127:981–6.CrossRef Singer CF, Tea MK, Pristauz G, et al. Clinical Practice Guideline for the prevention and early detection of breast and ovarian cancer in women from HBOC (hereditary breast and ovarian cancer) families. Wien Klin Wochenschr. 2015;127:981–6.CrossRef
6.
Zurück zum Zitat DGGG, DKG. Interdisciplinary screening, diagnosis, therapy and follow-up of breast cancer. Stuttgart: Thieme; 2018. Guideline of the DGGG and the DKG (S3-Level), AWMF Registry Number 032/045OL, December 2017. DGGG, DKG. Interdisciplinary screening, diagnosis, therapy and follow-up of breast cancer. Stuttgart: Thieme; 2018. Guideline of the DGGG and the DKG (S3-Level), AWMF Registry Number 032/045OL, December 2017.
8.
Zurück zum Zitat Lehman CD, Gatsonis C, Kuhl CK, et al. MRI evvaluation of the contralatral breast in women with recently diagnosed breast cancer. N Engl J Med. 2007;356:1295–303.CrossRef Lehman CD, Gatsonis C, Kuhl CK, et al. MRI evvaluation of the contralatral breast in women with recently diagnosed breast cancer. N Engl J Med. 2007;356:1295–303.CrossRef
9.
Zurück zum Zitat Andersopn K, Jacobson JS, Heitjan DF, et al. Cost-effectiveness of preventive strategies for women with a BRCA 1 or a BRCA2 mutation. Ann Intern Med. 2006;144:397–406.CrossRef Andersopn K, Jacobson JS, Heitjan DF, et al. Cost-effectiveness of preventive strategies for women with a BRCA 1 or a BRCA2 mutation. Ann Intern Med. 2006;144:397–406.CrossRef
10.
Zurück zum Zitat Early Breast Cancer Trialists’Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randmosed trials. Lancet. 2005;365:1687–1617.CrossRef Early Breast Cancer Trialists’Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randmosed trials. Lancet. 2005;365:1687–1617.CrossRef
11.
Zurück zum Zitat Reiner AS, John EM, Brooks JD, et al. Risk of asynchronous contralateral breast cancer in noncarriers of BRCA 1 and BRCA 2 utations with a family history of breast cancer: A report from the Women’s Enviromental Caner and Radiation Epidemiology Study. J Clin Oncol. 2013;31:433–9.CrossRef Reiner AS, John EM, Brooks JD, et al. Risk of asynchronous contralateral breast cancer in noncarriers of BRCA 1 and BRCA 2 utations with a family history of breast cancer: A report from the Women’s Enviromental Caner and Radiation Epidemiology Study. J Clin Oncol. 2013;31:433–9.CrossRef
12.
Zurück zum Zitat Early Breast Cancer Trialists’Collaborative Group (EBCTCG), Davies C, Godwin J, Gray R, et al. Relevance of breast cancer hormone receptors and other factord to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials. Lancet. 2011;378:771–84.CrossRef Early Breast Cancer Trialists’Collaborative Group (EBCTCG), Davies C, Godwin J, Gray R, et al. Relevance of breast cancer hormone receptors and other factord to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials. Lancet. 2011;378:771–84.CrossRef
14.
Zurück zum Zitat Bedrosian I, Hu CY, Chang GJ. Population-based study of contralateral prophylactic mastectomy and survival outcomes of breast cancer patients. J Natl Cancer Inst. 2010;102(6):401–9.CrossRef Bedrosian I, Hu CY, Chang GJ. Population-based study of contralateral prophylactic mastectomy and survival outcomes of breast cancer patients. J Natl Cancer Inst. 2010;102(6):401–9.CrossRef
16.
Zurück zum Zitat Zeichner SB, Zeichner SB, Ruiz AL, et al. Improvedlong-term survivalwith contralateral prophylactic mastectomy among young women. Asian Pac J Cancer Prev. 2014;15(3):1155–62.CrossRef Zeichner SB, Zeichner SB, Ruiz AL, et al. Improvedlong-term survivalwith contralateral prophylactic mastectomy among young women. Asian Pac J Cancer Prev. 2014;15(3):1155–62.CrossRef
17.
Zurück zum Zitat Zion SM, Slezak JM, Sellers TA, et al. Reoperations after prophylactic mastectomy with or without implant reconstruction. Cancer. 2003;98:2152–60.CrossRef Zion SM, Slezak JM, Sellers TA, et al. Reoperations after prophylactic mastectomy with or without implant reconstruction. Cancer. 2003;98:2152–60.CrossRef
18.
Zurück zum Zitat Miller ME, Czechura T, Martz B, et al. Operative risks associated with contralateral prophylactic mastectomy: A single institution experience. Ann Surg Oncol. 2013;20:4113–20.CrossRef Miller ME, Czechura T, Martz B, et al. Operative risks associated with contralateral prophylactic mastectomy: A single institution experience. Ann Surg Oncol. 2013;20:4113–20.CrossRef
19.
Zurück zum Zitat Silva AK, Lapin B, Yao KA, et al. The effect of contralateral prophylactic mastectomy on perioperative complications in women undergoing immediate breast reconstruction: A NSQIP analysis. Ann Surg Oncol. 2015;22:3474–80.CrossRef Silva AK, Lapin B, Yao KA, et al. The effect of contralateral prophylactic mastectomy on perioperative complications in women undergoing immediate breast reconstruction: A NSQIP analysis. Ann Surg Oncol. 2015;22:3474–80.CrossRef
20.
Zurück zum Zitat Osman F, Saleh F, Jackson TD, et al. Increased postoperative complications in bilateral mastectomy patients compared to unilateral mastectomy: An analysis of the NSQIP database. Ann Surg Oncol. 2013;20:3212–7.CrossRef Osman F, Saleh F, Jackson TD, et al. Increased postoperative complications in bilateral mastectomy patients compared to unilateral mastectomy: An analysis of the NSQIP database. Ann Surg Oncol. 2013;20:3212–7.CrossRef
21.
Zurück zum Zitat Sharpe SM, Liederbach E, Czechura T, et al. Impact of bilateral versus unilateral mastectomy on short term outcomes and adjuvant therapy, 2003–2010: A report from the National Cancer Data Base. Ann Surg Oncol. 2014;21:2920–7.CrossRef Sharpe SM, Liederbach E, Czechura T, et al. Impact of bilateral versus unilateral mastectomy on short term outcomes and adjuvant therapy, 2003–2010: A report from the National Cancer Data Base. Ann Surg Oncol. 2014;21:2920–7.CrossRef
22.
Zurück zum Zitat Koslow S, Pharmer LA, Scott AM, et al. Long-term patient-reported satisfaction after contralateral prophylactic mastectomy and implant reconstruction. Ann Surg Oncol. 2013;20:3422–9.CrossRef Koslow S, Pharmer LA, Scott AM, et al. Long-term patient-reported satisfaction after contralateral prophylactic mastectomy and implant reconstruction. Ann Surg Oncol. 2013;20:3422–9.CrossRef
23.
Zurück zum Zitat Hwang ES, Locklear TD, Rushing CN, et al. Patient-reported outcomes after choice for contralateral prophylactic mastectomy. J Clin Oncol. 2016;34(13):1518–27.CrossRef Hwang ES, Locklear TD, Rushing CN, et al. Patient-reported outcomes after choice for contralateral prophylactic mastectomy. J Clin Oncol. 2016;34(13):1518–27.CrossRef
24.
Zurück zum Zitat Mitchell A, Ferguson D, Gill J, Symonds P. Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: A systematic review and meta-analysis. Lancet Oncol. 2013;34:721–32.CrossRef Mitchell A, Ferguson D, Gill J, Symonds P. Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: A systematic review and meta-analysis. Lancet Oncol. 2013;34:721–32.CrossRef
25.
Zurück zum Zitat Schmitz K, Speck R, Sheree A, et al. Prevalence of breast cancer treatment sequelae over 6 years of follow up, the pulling through study. Cancer. 2012;118(8):2217–25.CrossRef Schmitz K, Speck R, Sheree A, et al. Prevalence of breast cancer treatment sequelae over 6 years of follow up, the pulling through study. Cancer. 2012;118(8):2217–25.CrossRef
28.
Zurück zum Zitat Frost MH, Scjhaid DJ, Sellers TA, et al. Long-term satisfaction and psychological and social function following bilateral prophylactic mastectomy. JAMA. 2000;284:319–24.CrossRef Frost MH, Scjhaid DJ, Sellers TA, et al. Long-term satisfaction and psychological and social function following bilateral prophylactic mastectomy. JAMA. 2000;284:319–24.CrossRef
Metadaten
Titel
Contralateral prophylactic mastectomy in women with breast cancer without a family history or genetic predisposition
Consensus statement from the Austrian Gynecologic Oncology Working Group of the Austrian Society of Obstetrics and Gynecology
verfasst von
Vesna Bjelic-Radisic, MD
Christian Singer
Karl Tamussino
Heinz Kölbl
Edgar Petru
Birgit Volgger
Stephan Polterauer
Peter Oppelt
Paul Sevelda
Gerhard Bogner
Christian Marth
Austrian Gynecologic Oncology Working Group
Publikationsdatum
18.03.2019
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 9-10/2019
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-019-1468-7

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