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27.04.2021 | short report Open Access

Attenuation of COVID-19-induced cytokine storm in a young male patient with severe respiratory and neurological symptoms

Zeitschrift:
Wiener klinische Wochenschrift
Autoren:
M.D. Assoc. Prof. Christian Muschitz, Anita Trummert, Theresa Berent, Norbert Laimer, Lukas Knoblich, Gerd Bodlaj, Alexander Krainer, Christoph Linder, Heinrich Resch
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Summary

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), produces protean manifestations and causes indiscriminate havoc in multiple organ systems. This rapid and vast production of proinflammatory cytokines contributes to a condition termed cytokine storm. A 35-year-old, otherwise healthy, employed, male patient was tested positive for COVID-19. He was admitted to the hospital on disease day 10 due to retarded verbal reactions and progressive delirium. On account of these conditions and the need for noninvasive/invasive ventilation, a combination treatment with baricitinib and remdesivir in conjunction with standard of care was initiated. The cytokine storm was rapidly blocked, leading to a vast pulmonary recovery with retarded recovery of the central nervous system. We conclude that the rapid blockade of the COVID-19-induced cytokine storm should be considered of avail as a principle of careful decision-making for effective recovery.

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