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27.04.2021 | short report Open Access

Attenuation of COVID-19-induced cytokine storm in a young male patient with severe respiratory and neurological symptoms

Wiener klinische Wochenschrift
M.D. Assoc. Prof. Christian Muschitz, Anita Trummert, Theresa Berent, Norbert Laimer, Lukas Knoblich, Gerd Bodlaj, Alexander Krainer, Christoph Linder, Heinrich Resch
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Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), produces protean manifestations and causes indiscriminate havoc in multiple organ systems. This rapid and vast production of proinflammatory cytokines contributes to a condition termed cytokine storm. A 35-year-old, otherwise healthy, employed, male patient was tested positive for COVID-19. He was admitted to the hospital on disease day 10 due to retarded verbal reactions and progressive delirium. On account of these conditions and the need for noninvasive/invasive ventilation, a combination treatment with baricitinib and remdesivir in conjunction with standard of care was initiated. The cytokine storm was rapidly blocked, leading to a vast pulmonary recovery with retarded recovery of the central nervous system. We conclude that the rapid blockade of the COVID-19-induced cytokine storm should be considered of avail as a principle of careful decision-making for effective recovery.

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