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Erschienen in:

15.06.2021 | original article

COVID-19-associated myoclonus in a series of five critically ill patients

verfasst von: Alexander Grieb, BScMed, Tamara Seitz, Reinhard Kitzberger, Manfred Schmidbauer, Wolfgang Hoepler, Sebastian Baumgartner, Marianna T. Traugott, Erich Pawelka, Mario Karolyi, Georg Strasser, Karolina Knibbe, Hermann Laferl, Alexander Zoufaly, Christoph Wenisch, Stephanie Neuhold

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 17-18/2021

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Summary

Background

In addition to respiratory symptoms, many patients with coronavirus disease 2019 (COVID-19) present with neurological complications. Several case reports and small case series described myoclonus in five patients suffering from the disease. The purpose of this article is to report on five critically ill patients with COVID-19-associated myoclonus.

Material and methods

The clinical courses and test results of patients treated in the study center ICU and those of partner hospitals are described. Imaging, laboratory tests and electrophysiological test results are reviewed and discussed.

Results

In severe cases of COVID-19 myoclonus can manifest about 3 weeks after initial onset of symptoms. Sedation is sometimes effective for symptom control but impedes respiratory weaning. No viral particles or structural lesions explaining this phenomenon were found in this cohort.

Conclusion

Myoclonus in patients with severe COVID-19 may be due to an inflammatory process, hypoxia or GABAergic impairment. Most patients received treatment with antiepileptic or anti-inflammatory agents and improved clinically.
Literatur
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Metadaten
Titel
COVID-19-associated myoclonus in a series of five critically ill patients
verfasst von
Alexander Grieb, BScMed
Tamara Seitz
Reinhard Kitzberger
Manfred Schmidbauer
Wolfgang Hoepler
Sebastian Baumgartner
Marianna T. Traugott
Erich Pawelka
Mario Karolyi
Georg Strasser
Karolina Knibbe
Hermann Laferl
Alexander Zoufaly
Christoph Wenisch
Stephanie Neuhold
Publikationsdatum
15.06.2021
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 17-18/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-021-01890-3