Skip to main content
Erschienen in: European Surgery 6/2021

14.10.2021 | original article

Towards a zero percent anastomotic leak rate using a defined risk reduction strategy

verfasst von: Sergei Bedrikovetski, Nagendra N. Dudi-Venkata, Hidde M. Kroon, Ryash Vather, Tarik Sammour

Erschienen in: European Surgery | Ausgabe 6/2021

Einloggen, um Zugang zu erhalten

Summary

Background

Anastomotic leak (AL) remains one of the most serious complications after colorectal surgery. This study reports prospective data on a defined risk reduction strategy used by one surgeon over a 3-year period.

Methods

Using a single surgeon case series with a predefined risk reduction strategy for all anastomoses, a prospectively maintained database on demographic, perioperative, and postoperative outcomes of patients undergoing colorectal resections with formation of anastomosis between January 2017 and July 2020 was evaluated. Data were analysed using descriptive statistics.

Results

There were 145 anastomoses formed in 134 patients. The median age of patients was 67 years (32–87), and the mean body mass index (BMI) was 27.7 kg/m2. Seventy-three (50.3%) procedures were performed open and 72 (49.7%) were minimally invasive. Major complications (Clavien–Dindo grade ≥3) occurred in 13 (9.0%) cases. Two patients had an AL (1.3%) that could be treated with antibiotics (grade A). No patient experienced grade B or C leaks (requiring intervention). Median length of hospital stay was 8 days, and 2 patients died within 30-days postoperatively (1.4%).

Conclusions

A predefined risk reduction strategy may help improve patient selection and reduce anastomotic leak rates. A prospective comparative study is warranted.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat McDermott FD, Heeney A, Kelly ME, Steele RJ, Carlson GL, Winter DC. Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg. 2015;102(5):462–79.CrossRef McDermott FD, Heeney A, Kelly ME, Steele RJ, Carlson GL, Winter DC. Systematic review of preoperative, intraoperative and postoperative risk factors for colorectal anastomotic leaks. Br J Surg. 2015;102(5):462–79.CrossRef
2.
Zurück zum Zitat Slieker JC, Daams F, Mulder IM, Jeekel J, Lange JF. Systematic review of the technique of colorectal anastomosis. JAMA Surg. 2013;148(2):190–201.CrossRef Slieker JC, Daams F, Mulder IM, Jeekel J, Lange JF. Systematic review of the technique of colorectal anastomosis. JAMA Surg. 2013;148(2):190–201.CrossRef
3.
Zurück zum Zitat Boyce SA, Harris C, Stevenson A, Lumley J, Clark D. Management of low colorectal anastomotic leakage in the laparoscopic era: more than a decade of experience. Dis Colon Rectum. 2017;60(8):807–14.CrossRef Boyce SA, Harris C, Stevenson A, Lumley J, Clark D. Management of low colorectal anastomotic leakage in the laparoscopic era: more than a decade of experience. Dis Colon Rectum. 2017;60(8):807–14.CrossRef
4.
Zurück zum Zitat Snijders HS, Wouters MW, van Leersum NJ, Kolfschoten NE, Henneman D, de Vries AC, et al. Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality. Eur J Surg Oncol. 2012;38(11):1013–9.CrossRef Snijders HS, Wouters MW, van Leersum NJ, Kolfschoten NE, Henneman D, de Vries AC, et al. Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality. Eur J Surg Oncol. 2012;38(11):1013–9.CrossRef
5.
Zurück zum Zitat Frasson M, Flor-Lorente B, Rodriguez JL, Granero-Castro P, Hervas D, Alvarez Rico MA, et al. Risk factors for anastomotic leak after colon resection for cancer: multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 patients. Ann Surg. 2015;262(2):321–30.CrossRef Frasson M, Flor-Lorente B, Rodriguez JL, Granero-Castro P, Hervas D, Alvarez Rico MA, et al. Risk factors for anastomotic leak after colon resection for cancer: multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 patients. Ann Surg. 2015;262(2):321–30.CrossRef
6.
Zurück zum Zitat Lee SW, Gregory D, Cool CL. Clinical and economic burden of colorectal and bariatric anastomotic leaks. Surg Endosc. 2020;34(10):4374–81.CrossRef Lee SW, Gregory D, Cool CL. Clinical and economic burden of colorectal and bariatric anastomotic leaks. Surg Endosc. 2020;34(10):4374–81.CrossRef
7.
Zurück zum Zitat Park JS, Choi GS, Kim SH, Kim HR, Kim NK, Lee KY, et al. Multicenter analysis of risk factors for anastomotic leakage after laparoscopic rectal cancer excision: the Korean laparoscopic colorectal surgery study group. Ann Surg. 2013;257(4):665–71.CrossRef Park JS, Choi GS, Kim SH, Kim HR, Kim NK, Lee KY, et al. Multicenter analysis of risk factors for anastomotic leakage after laparoscopic rectal cancer excision: the Korean laparoscopic colorectal surgery study group. Ann Surg. 2013;257(4):665–71.CrossRef
8.
Zurück zum Zitat Bakker IS, Grossmann I, Henneman D, Havenga K, Wiggers T. Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit. Br J Surg. 2014;101(4):424–32. discussion 32.CrossRef Bakker IS, Grossmann I, Henneman D, Havenga K, Wiggers T. Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit. Br J Surg. 2014;101(4):424–32. discussion 32.CrossRef
10.
Zurück zum Zitat Moug SJ, Henderson N, Tiernan J, Bisset CN, Ferguson E, Harji D, et al. The colorectal surgeon’s personality may influence the rectal anastomotic decision. Colorectal Dis. 2018;20(11):970–80.CrossRef Moug SJ, Henderson N, Tiernan J, Bisset CN, Ferguson E, Harji D, et al. The colorectal surgeon’s personality may influence the rectal anastomotic decision. Colorectal Dis. 2018;20(11):970–80.CrossRef
11.
Zurück zum Zitat Crebbin W, Beasley SW, Watters DA. Clinical decision making: how surgeons do it. ANZ J Surg. 2013;83(6):422–8.CrossRef Crebbin W, Beasley SW, Watters DA. Clinical decision making: how surgeons do it. ANZ J Surg. 2013;83(6):422–8.CrossRef
12.
Zurück zum Zitat Benchimol EI, Smeeth L, Guttmann A, Harron K, Moher D, Petersen I, et al. The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. PLoS Med. 2015;12(10):e1001885.CrossRef Benchimol EI, Smeeth L, Guttmann A, Harron K, Moher D, Petersen I, et al. The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement. PLoS Med. 2015;12(10):e1001885.CrossRef
13.
Zurück zum Zitat Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.CrossRef Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.CrossRef
14.
Zurück zum Zitat Reisinger KW, Poeze M, Hulsewe KW, van Acker BA, van Bijnen AA, Hoofwijk AG, et al. Accurate prediction of anastomotic leakage after colorectal surgery using plasma markers for intestinal damage and inflammation. J Am Coll Surg. 2014;219(4):744–51.CrossRef Reisinger KW, Poeze M, Hulsewe KW, van Acker BA, van Bijnen AA, Hoofwijk AG, et al. Accurate prediction of anastomotic leakage after colorectal surgery using plasma markers for intestinal damage and inflammation. J Am Coll Surg. 2014;219(4):744–51.CrossRef
15.
Zurück zum Zitat Rahbari NN, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A, et al. Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery. 2010;147(3):339–51.CrossRef Rahbari NN, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A, et al. Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery. 2010;147(3):339–51.CrossRef
16.
Zurück zum Zitat Kang CY, Halabi WJ, Chaudhry OO, Nguyen V, Pigazzi A, Carmichael JC, et al. Risk factors for anastomotic leakage after anterior resection for rectal cancer. JAMA Surg. 2013;148(1):65–71.CrossRef Kang CY, Halabi WJ, Chaudhry OO, Nguyen V, Pigazzi A, Carmichael JC, et al. Risk factors for anastomotic leakage after anterior resection for rectal cancer. JAMA Surg. 2013;148(1):65–71.CrossRef
17.
Zurück zum Zitat Yamamoto T, Spinelli A, Suzuki Y, Saad-Hossne R, Teixeira FV, de Albuquerque IC, et al. Risk factors for complications after ileocolonic resection for Crohn’s disease with a major focus on the impact of preoperative immunosuppressive and biologic therapy: a retrospective international multicentre study. United European Gastroenterol J. 2016;4(6):784–93.CrossRef Yamamoto T, Spinelli A, Suzuki Y, Saad-Hossne R, Teixeira FV, de Albuquerque IC, et al. Risk factors for complications after ileocolonic resection for Crohn’s disease with a major focus on the impact of preoperative immunosuppressive and biologic therapy: a retrospective international multicentre study. United European Gastroenterol J. 2016;4(6):784–93.CrossRef
18.
Zurück zum Zitat Sammour T, Cohen L, Karunatillake AI, Lewis M, Lawrence MJ, Hunter A, et al. Validation of an online risk calculator for the prediction of anastomotic leak after colon cancer surgery and preliminary exploration of artificial intelligence-based analytics. Tech Coloproctol. 2017;21(11):869–77.CrossRef Sammour T, Cohen L, Karunatillake AI, Lewis M, Lawrence MJ, Hunter A, et al. Validation of an online risk calculator for the prediction of anastomotic leak after colon cancer surgery and preliminary exploration of artificial intelligence-based analytics. Tech Coloproctol. 2017;21(11):869–77.CrossRef
19.
Zurück zum Zitat Sammour T, Hill AG. Should colorectal surgeons continue to use nonsteroidal anti-inflammatory drugs? ANZ J Surg. 2017;87(11):861–2.CrossRef Sammour T, Hill AG. Should colorectal surgeons continue to use nonsteroidal anti-inflammatory drugs? ANZ J Surg. 2017;87(11):861–2.CrossRef
20.
Zurück zum Zitat Jolly S, Dudi-Venkata NN, Hanna-Rivero N, Kroon HM, Reid FSW, Sammour T. Four different ileorectal anastomotic configurations following total colectomy. ANZ J Surg. 2020;90(9):1588–91.CrossRef Jolly S, Dudi-Venkata NN, Hanna-Rivero N, Kroon HM, Reid FSW, Sammour T. Four different ileorectal anastomotic configurations following total colectomy. ANZ J Surg. 2020;90(9):1588–91.CrossRef
21.
Zurück zum Zitat Moghadamyeghaneh Z, Hanna MH, Alizadeh RF, Carmichael JC, Mills S, Pigazzi A, et al. Contemporary management of anastomotic leak after colon surgery: assessing the need for reoperation. Am J Surg. 2016;211(6):1005–13.CrossRef Moghadamyeghaneh Z, Hanna MH, Alizadeh RF, Carmichael JC, Mills S, Pigazzi A, et al. Contemporary management of anastomotic leak after colon surgery: assessing the need for reoperation. Am J Surg. 2016;211(6):1005–13.CrossRef
22.
Zurück zum Zitat Bedrikovetski S, Dudi-Venkata NN, Kroon HM, Moore JW, Hunter RA, Sammour T. Outcomes of minimally invasive versus open proctectomy for rectal cancer: a propensity-matched analysis of bi-national colorectal cancer audit data. Dis Colon Rectum. 2020;63(6):778–87.CrossRef Bedrikovetski S, Dudi-Venkata NN, Kroon HM, Moore JW, Hunter RA, Sammour T. Outcomes of minimally invasive versus open proctectomy for rectal cancer: a propensity-matched analysis of bi-national colorectal cancer audit data. Dis Colon Rectum. 2020;63(6):778–87.CrossRef
23.
Zurück zum Zitat Smith SA, Roberts DJ, Lipson ME, Buie WD, MacLean AR. Postoperative nonsteroidal anti-inflammatory drug use and intestinal anastomotic dehiscence: a systematic review and meta-analysis. Dis Colon Rectum. 2016;59(11):1087–97.CrossRef Smith SA, Roberts DJ, Lipson ME, Buie WD, MacLean AR. Postoperative nonsteroidal anti-inflammatory drug use and intestinal anastomotic dehiscence: a systematic review and meta-analysis. Dis Colon Rectum. 2016;59(11):1087–97.CrossRef
24.
Zurück zum Zitat Meyer J, Naiken S, Christou N, Liot E, Toso C, Buchs NC, et al. Reducing anastomotic leak in colorectal surgery: the old dogmas and the new challenges. World J Gastroenterol. 2019;25(34):5017–25.CrossRef Meyer J, Naiken S, Christou N, Liot E, Toso C, Buchs NC, et al. Reducing anastomotic leak in colorectal surgery: the old dogmas and the new challenges. World J Gastroenterol. 2019;25(34):5017–25.CrossRef
25.
Zurück zum Zitat Gaines S, Shao C, Hyman N, Alverdy JC. Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery. Br J Surg. 2018;105(2):e131–e41.CrossRef Gaines S, Shao C, Hyman N, Alverdy JC. Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery. Br J Surg. 2018;105(2):e131–e41.CrossRef
Metadaten
Titel
Towards a zero percent anastomotic leak rate using a defined risk reduction strategy
verfasst von
Sergei Bedrikovetski
Nagendra N. Dudi-Venkata
Hidde M. Kroon
Ryash Vather
Tarik Sammour
Publikationsdatum
14.10.2021
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 6/2021
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-021-00739-3

Weitere Artikel der Ausgabe 6/2021

European Surgery 6/2021 Zur Ausgabe