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01.09.2016 | original article | Ausgabe 17-18/2016

Wiener klinische Wochenschrift 17-18/2016

The relationship between visfatin, liver inflammation, and acute phase reactants in chronic viral hepatitis B

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 17-18/2016
Autoren:
MD Enver Yüksel, MD Erdem Akbal, MD Erdem Koçak, MD Ömer Akyürek, MD Seyfettin Köklü, Fuat Ekiz, Barış Yılmaz

Summary

Chronic viral hepatitis B (CHB) is an important cause of morbidity and mortality. Adipokine stimulation might play an important role in the pathogenesis of chronic inflammation. The aim of this study was to evaluate serum visfatin concentrations and the relationship between visfatin, fibrosis, liver inflammation, and acute phase reactants in CHB patients.
The sampling universe of the study consisted of 41 CHB patients and 25 healthy controls. All patients had positive hepatitis B surface antigen (Hepatitis e antigen (HBeAg) positive n: 7, n: 34 HBeAg negative) for at least 6 months and detectable serum HBV DNA. Serum visfatin concentrations were significantly higher in the CHB patients [18.0 ± 10.9 ng dL−1] than in the healthy controls [9.4 ± 1.6 ng dL−1] [P < 0.001]. On the other hand, fibrinogen and haptoglobin concentrations were significantly lower in CHB patients. A strong negative correlation was observed between serum visfatin concentration, haptoglobin, and fibrinogen levels; however, there was no significant correlation between visfatin, glucose, alanine aminotransferase, aspartate aminotransferase, BMI, Knodell score, fibrosis score, hepatitis B virus DNA, sedimentation, and C-reactive protein. Visfatin concentrations were elevated and visfatin was negatively correlated with haptoglobin and fibrinogen levels in CHB patients.

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