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01.08.2014 | Original Article | Ausgabe 4/2014

European Surgery 4/2014

Solid organ recipients are at increased risk for recurrent Clostridium difficile colitis

Zeitschrift:
European Surgery > Ausgabe 4/2014
Autoren:
Univ. Doz. H. J. R. Bonatti, MD R. Metzger, MD B. R. Swenson, MD S. Pawlowski, MD R. W. Krell, MD T. L. Pruett, MD K. L. Brayman, MD C. D. Sifri, MD R. G. Sawyer

Summary

Background

Solid organ transplant (SOT) recipients carry a high risk of developing Clostridium difficile-associated colitis (CDAC) and an increased risk for recurrence.

Patients and methods

Between December 1996 and September 2007, a total of 227 patients with CDAC were identified when querying our institutional surgical infection database. This included 169 nontransplant patients and 58 SOT recipients, including 1 cardiac, 19 renal, 2 pancreas, 5 renal/pancreas, and 31 liver recipients.

Results

Overall, we recorded 556 infectious episodes at any site in the 227 patients analyzed who eventually developed CDAC (2.4 episodes/patient); the total number of CDAC episodes was 255: 204 patients had a single episode and 23 patients had multiple episodes of CDAC. There were 19 patients with two episodes, 3 with three episodes, and 1 with four episodes. Of the 23 patients with recurrent CDAC, 11 (48 %) were SOT recipients. A total of 19 % of SOT recipients had recurrent CDAC as compared with only 7 % for nontransplant patients (p = 0.0197). Time to first CDAC recurrence was a median of 58 (range, 17–1372) days for SOT recipients and a median of 30 (range, 6–108) days for nontransplant patients (p = 0.047).

Conclusions

SOT recipients at our institution were found to be a high-risk group for CDAC and had an almost threefold risk for recurrent disease. Double-drug coverage, extended application of metronidazole, and profound reduction in the level of immunosuppression may help to cope with this emerging problem.

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