Skip to main content
Erweiterte Suche
Anmelden
nach oben
European Surgery
Erschienen in:

01.08.2014 | Short Communication

Poor sensitivity of 99mTc-labeled ubiquicidin scintigraphy in diagnosis of acute appendicitis

verfasst von: M. Kahrom, MD, M. Mehrabi Bahar, MD, A. Jangjoo, MD, M. Erfani, MD, R. Sadeghi, MD, Prof. S. R. Zakavi, MD, IBNM

Erschienen in: European Surgery | Ausgabe 4/2014

Einloggen, um Zugang zu erhalten

Summary

Background

Ubiquicidin 29–41 (UBI) is an antimicrobial peptide.

Methods

In total eight men and two women with high probability of acute appendicitis were serially imaged for up to 30 min after the intravenous administration of 370 MBq of 99mTc-UBI, before surgical exploration

Results

The scan showed mild to moderate increased uptake in the right lower quadrant in six patients. Quantitative analysis failed to show any difference between suppurative and gangrenous appendicitis.

Conclusion

99mTc-UBI scintigraphy has 20 % sensitivity for diagnosis of acute appendicitis.
Vorheriger Artikel An unusual case of excessive sweating affecting the right upper limb after bilateral endoscopic thoracic sympathectomy for primary palmar hyperhidrosis: recurrence or compensatory hyperhidrosis?
Literatur
1.
Antal A. Changes in epidemiology, etiology, diagnostics, and therapy of acute appendicitis. Orv Hetil. 2009;150(10):443–6.PubMedCrossRef
2.
Bretagnol F, Zappa M, Panis Y. Ultrasound and CT imaging in the diagnosis of acute appendicitis. J Chir (Paris). 2009;146(Spec No 1):8–11.
3.
Rypins EB, Evans DG, Hinrichs W, Kipper SL. Tc-99m-HMPAO white blood cell scan for diagnosis of acute appendicitis in patients with equivocal clinical presentation. Ann Surg. 1997;226(1):58–65.PubMedCentralPubMedCrossRef
4.
Kim E, Subhas G, Mittal VK, Golladay ES. C-reactive protein estimation does not improve accuracy in the diagnosis of acute appendicitis in pediatric patients. Int J Surg. 2009;7(1):74–7.PubMedCrossRef
5.
Asadi M, Mehrabi Bahar M, Sadeghi R, Jangjo A, Dabbagh Kakhki V, Zakavi SR. Value of polyclonal human immunoglobulin tagged with (99m)Tc for detecting acute appendicitis in patients with intermediate probability of appendicitis. World J Surg. 2011;35:1798–1802.
6.
Kerry JE, Marshall C, Griffiths PA, James MW, Scott BB. Comparison between Tc-HMPAO labelled white cells and Tc LeukoScan in the investigation of inflammatory bowel disease. Nucl Med Commun. 2005;26(3):245–51.PubMedCrossRef
7.
Sarda-Mantel L, Saleh-Mghir A, Welling MM, Meulemans A, Vrigneaud JM, Raguin O, et al. Evaluation of 99mTc-UBI 29–41 scintigraphy for specific detection of experimental Staphylococcus aureus prosthetic joint infections. Eur J Nucl Med Mol Imaging. 2007;34(8):1302–9.PubMedCrossRef
8.
Welling MM, Korsak A, Gorska B, Oliver P, Mikolajczak R, Balter HS, et al. Kit with technetium-99m labelled antimicrobial peptide UBI 29–41 for specific infection detection. J Label Compd Radiopharm. 2005;48(9):683–91.CrossRef
9.
Welling MM, Paulusma-Annema A, Balter HS, Pauwels EKJ, Nibbering PH. Technetium-99m labelled antimicrobial peptides discriminate between bacterial infections and sterile inflammations. Eur J Nucl Med. 2000;27(3):292–301.PubMedCrossRef
10.
Melendez-Alafort L, Rodriguez-Cortis J, Ferro-Flores G, Arteaga De Murphy C, Herrera-Rodriguez R, Mitsoura E, et al. Biokinetics of 99mTc-UBI 29–41 in humans. Nucl Med Biol. 2004;31(3):373–9.PubMedCrossRef
11.
Welling MM, Mongera S, Lupetti A, Balter HS, Bonetto V, Mazzi U, et al. Radiochemical and biological characteristics of 99mTc-UBI 29–41 for imaging of bacterial infections. Nucl Med Biol. 2002;29(4):413–22.PubMedCrossRef
12.
Gandomkar M, Najafi R, Mazidi M, Goudarzi M, Mirfallah SH. New peptide based freeze-dried kit [99mTc-HYNIC]-UBI 29–41 as a human specific infection imaging agent. Iran J Nucl Med. 2008;16(29):25–30.
13.
Vallejo E, Martinez I, Tejero A, Hernandez S, Jimenez L, Bialostozky D, et al. Clinical utility of 99mTc-labeled ubiquicidin 29–41 antimicrobial peptide for the scintigraphic detection of mediastinitis after cardiac surgery. Arch Med Res. 2008;39(8):768–74.PubMedCrossRef
14.
Akhtar MS, Khan ME, Khan B, Irfanullah J, Afzal MS, Khan MA, et al. An imaging analysis of 99mTc-UBI (29–41) uptake in S. aureus infected thighs of rabbits on ciprofloxacin treatment. Eur J Nucl Med Mol Imaging. 2008;35(6):1056–64.PubMedCrossRef
15.
Gandomkar M, Najafi R, Shafiei M, Mazidi M, Goudarzi M, Mirfallah SH, et al. Clinical evaluation of antimicrobial peptide [(99m)Tc/Tricine/HYNIC(0)]ubiquicidin 29–41 as a human-specific infection imaging agent. Nucl Med Biol. 2009;36(2):199–205.PubMedCrossRef
16.
Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990;132(5):910–25.PubMed
17.
Jess P, Bjerregaard B, Brynitz S, Holst-Christensen J, Kalaja E, Lund-Kristensen J. Acute appendicitis. Prospective trial concerning diagnostic accuracy and complications. Am J Surg. 1981;141(2):232–4.PubMedCrossRef
18.
Basta M, Morton NE, Mulvihill JJ, Radovanovic Z, Radojicic C, Marinkovic D. Inheritance of acute appendicitis: familial aggregation and evidence of polygenic transmission. Am J Hum Genet. 1990;46(2):377–82.PubMedCentralPubMed
19.
Sadr Azodi O, Andren-Sandberg A, Larsson H. Genetic and environmental influences on the risk of acute appendicitis in twins. Br J Surg. 2009;96(11):1336–40.PubMedCrossRef
20.
21.
Shung-Shung S, Yu-Chien S, Mei-Due Y, Hwei-Chung W, Kao A. Improving the diagnosis of acute appendicitis with atypical findings by Tc-99m HMPAO leukocyte scan. Nuklearmedizin. 2002;41(1):37–41.PubMed
22.
Biersack HJ, Overbeck B, Ott G, Kania U, Briele B, Kropp J, et al. Tc-99m labeled monoclonal antibodies against granulocytes (BW 250/183) in the detection of appendicitis. Clin Nucl Med. 1993;18(5):371–6.PubMedCrossRef
23.
Rypins EB, Kipper SL, Weiland F, Neal C, Line B, McDonald R, et al. 99m Tc anti-CD 15 monoclonal antibody (LeuTech) imaging improves diagnostic accuracy and clinical management in patients with equivocal presentation of appendicitis. Ann Surg. 2002;235(2):232–9.PubMedCentralPubMedCrossRef
24.
Welling MM, Visentin R, Feitsma HIJ, Lupetti A, Pauwels EKJ, Nibbering PH. Infection detection in mice using 99mTc-labeled HYNIC and N 2S2 chelate conjugated to the antimicrobial peptide UBI 29–41. Nucl Med Biol. 2004;31(4):503–9.PubMedCrossRef
25.
Nibbering PH, Welling MM, Paulusma-Annema A, Brouwer CPJM, Lupetti A, Pauwels EKJ. 99mTc-labeled UBI 29–41 peptide for monitoring the efficacy of antibacterial agents in mice infected with Staphylococcus aureus. J Nucl Med. 2004;45(2):321–6.PubMed
26.
Akhtar MS, Qaisar A, Irfanullah J, Iqbal J, Khan B, Jehangir M, et al. Antimicrobial peptide 99mTc-ubiquicidin 29–41 as human infection-imaging agent: clinical trial. J Nucl Med. 2005;46(4):567–73.PubMed
27.
Lupetti A, Welling MM, Pauwels EK, Nibbering PH. Radiolabelled antimicrobial peptides for infection detection. Lancet Infect Dis. 2003;3(4):223–9.PubMedCrossRef
28.
Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med. 1986;15(5):557–64.PubMedCrossRef
29.
Akhtar MS, Iqbal J, Khan MA, Irfanullah J, Jehangir M, Khan B, et al. 99mTc-labeled antimicrobial peptide ubiquicidin (29–41) accumulates less in Escherichia coli infection than in Staphlococcus aureus infection. J Nucl Med. 2004;45(5):849–56.PubMed
30.
Oltmann SC, Brekke AV, Macatangay JD, Schneider DF, Chen H, Sippel RS, Surgeon and staff radiation exposure during radioguided parathyroidectomy at a high-volume institution. Ann Surg Oncol. 2014. doi:10.1245/s10434-014-3822-3.
Metadaten
Titel
Poor sensitivity of 99mTc-labeled ubiquicidin scintigraphy in diagnosis of acute appendicitis
verfasst von
M. Kahrom, MD
M. Mehrabi Bahar, MD
A. Jangjoo, MD
M. Erfani, MD
R. Sadeghi, MD
Prof. S. R. Zakavi, MD, IBNM
Publikationsdatum
01.08.2014
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 4/2014
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-014-0278-4

Weitere Artikel der Ausgabe 4/2014

Two class medicine: the essence hits it all

  • Editorial

Supraclavicular node metastasis in thoracic esophageal squamous cell carcinoma

  • Original Article

The effect of using methylene blue in surgical treatments of pilonidal disease: a prospective randomized study

  • Original Article

An unusual case of excessive sweating affecting the right upper limb after bilateral endoscopic thoracic sympathectomy for primary palmar hyperhidrosis: recurrence or compensatory hyperhidrosis?

  • Case Report

Solid organ recipients are at increased risk for recurrent Clostridium difficile colitis

  • Original Article

Over-the-scope endoclipping for foregut leaks and perforations

  • Original Article