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European Surgery
Erschienen in:

01.06.2015 | Original Article

Significant relationship between preoperative serum concentration of anti-heat shock protein 70 antibody and postoperative morbidity in patients with esophageal cancer

verfasst von: M. Nakajima, MD, PhD, FACS, H. Kato, MD, PhD, FACS, M. Sakai, MD, PhD, A. Sano, MD, PhD, T. Miyazaki, MD, PhD, FACS, M. Sohda, MD, PhD, T. Inose, MD, PhD, T. Yokobori, MD, PhD, N. Tanaka, MD, PhD, S. Suzuki, MD, N. Masuda, MD, PhD, M. Fukuchi, MD, PhD, H. Kuwano, MD, PhD, FACS

Erschienen in: European Surgery | Ausgabe 3/2015

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Summary

Background

Heat shock protein 70 is a molecular chaperone important in host responses to stress, including infection, injury, oxidative damage, hypoxia, and thermal stress. This study analyzed the correlation between preoperative serum concentrations of anti-HPS70 antibody and postoperative morbidity in patients with esophageal cancer.

Materials and methods

Serum samples were obtained preoperatively from 50 esophageal carcinoma patients (46 men and 4 women) who underwent potentially curative surgery without preoperative therapy. Serum anti-HSP70 antibody concentrations were measured by enzyme-linked immunosorbent assays.

Results

The mean concentration of anti-HSP70 antibody was 187.0 μg/mL. When patients were dichotomized relative to this cutoff, we observed no significant relationships between perioperative inflammatory markers (maximum body temperature, white blood cell count and C-reactive protein concentration) and anti-HSP70 antibody concentration. The incidence of postoperative complications was significantly lower in patients with anti-HSP ≥ 187.0 μg/mL than < 187.0 μg/mL (p = 0.0336).

Conclusions

Preoperative serum concentration of anti-HSP70 antibody was significantly related to postoperative morbidities in patients with esophageal cancer.
Vorheriger Artikel Stapled hemorrhoidopexy versus Milligan–Morgan hemorrhoidectomy: a short-term follow-up on 640 consecutive patients
Nächster Artikel Pathophysiology of airway obstruction caused by wound hematoma after thyroidectomy: an ex vivo study
Literatur
1.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN. 2008. Int J Cancer. 2010;127(12):2893–917.PubMedCrossRef
2.
Sharaiha RZ, Halazun KJ, Mirza F, et al. Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol. 2011;18(12):3362–9.PubMedCentralPubMedCrossRef
3.
Biere SS, Maas KW, Cuesta MA, van der Peet DL. Cervical or thoracic anastomosis after esophagectomy for cancer: a systematic review and meta-analysis. Dig Surg. 2011;28(1):29–35.PubMedCrossRef
4.
Glatz T, Marjanovic G, Zirlik K, et al. Surgical treatment of esophageal cancer: evolution of management and prognosis over the last 3 decades. Chirurg. 2014 ([Epub ahead of print] German).
5.
Benedix F, Dalicho SF, Stübs P, et al. Evidence base for minimally invasive esophagectomy for esophageal cancer. Chirurg. 2014;85(8):668–74 (German).PubMedCrossRef
6.
Hoeppner J, Marjanovic G, Glatz T, et al. Hybrid laparoscopic thoracotomic esophagectomy with intrathoracic esophagogastric anastomosis. Chirurg. 2014;85(7):628–35 (German).PubMedCrossRef
7.
8.
Vega VL, Rodríguez-Silva M, Frey T, et al. HSP70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol. 2008;180(6):4299–307.PubMedCrossRef
9.
Nakajima M, Kuwano H, Miyazaki T, Masuda N, Kato H. Significant correlation between expression of heat shock proteins 27, 70 and lymphocyte infiltration in esophageal squamous cell carcinoma. Cancer Lett. 2002;178(1):99–106.PubMedCrossRef
10.
Nakajima M, Kato H, Miyazaki T, et al. Tumor immune systems in esophageal cancer with special reference to heat-shock protein 70 and humoral immunity. Anticancer Res. 2009;29(5):1595–606.PubMed
11.
Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G. Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle. 2006;5(22):2592–601.PubMedCrossRef
12.
Jäättelä M, Wissing D. Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection. J Exp Med. 1993;177(1):231–6.PubMedCrossRef
13.
14.
Ran R, Lu A, Zhang L, et al. HSP70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling. Genes Dev. 2004;18(12):1466–81.PubMedCentralPubMedCrossRef
15.
Park KJ, Gaynor RB, Kwak YT. Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation. J Biol Chem. 2003;278(37):35272–8.PubMedCrossRef
16.
Saito K, Dai Y, Ohtsuka K. Enhanced expression of heat shock proteins in gradually dying cells and their release from necrotically dead cells. Exp Cell Res. 2005;310(1):229–36.PubMedCrossRef
17.
Clayton A, Turkes A, Navabi H, Manson MD, Tabi Z. Induction of heat shock proteins in B-cell exosomes. J Cell Sci. 2005;118(Pt 16):3631–8.PubMedCrossRef
18.
Asea A, Kraeft SK, Kurt-Jones EA, et al. HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med. 2000;6(4):435–42.PubMedCrossRef
19.
Panjwani NN, Popova L, Srivastava PK. Heat shock proteins gp96 and hsp70 activate the release of nitric oxide by APCs. J Immunol. 2002;168(6):2997–3003.PubMedCrossRef
20.
Lehner T, Bergmeier LA, Wang Y, et al. Heat shock proteins generate beta-chemokines which function as innate adjuvants enhancing adaptive immunity. Eur J Immunol. 2000;30(2):594–603.PubMedCrossRef
21.
Pan PJ, Chan RC, Yang AH, Chou CL, Cheng YF, Chiu JL. Protective effects of preconditioned local somatothermal stimulation on neuromuscular plasticity against ischemia—reperfusion injury in rats. J Orthop Res. 2008;26(12):1670–4.PubMedCrossRef
22.
Jones Q, Voegeli TS, Li G, Chen Y, Currie RW. Heat shock proteins protect against ischemia and inflammation through multiple mechanisms. Inflamm Allergy Drug Targets. 2011;10(4):247–59.PubMedCrossRef
23.
St Rammos K, Koullias GJ, Hassan MO, et al. Low preoperative HSP70 atrial myocardial levels correlate significantly with high incidence of postoperative atrial fibrillation after cardiac surgery. Cardiovasc Surg. 2002; 10(3): 228–32.CrossRef
24.
Newkirk MM, Mitchell S, Procino M, et al. Chronic smoke exposure induces rheumatoid factor and anti-heat shock protein 70 autoantibodies in susceptible mice and humans with lung disease. Eur J Immunol. 2012;42(4):1051–61.PubMedCrossRef
25.
Helgeland G, Petzold A, Hoff JM, Gilhus NE, Plant GT, Romi FR. Anti-heat shock protein 70 antibody levels are increased in myasthenia gravis and Guillain-Barré syndrome. J Neuroimmunol. 2010;225(1–2):180–3.PubMedCrossRef
26.
Zhang X, Xu Z, Zhou L, et al. Plasma levels of HSP70 and anti-HSP70 antibody predict risk of acute coronary syndrome. Cell Stress Chaperones. 2010;15(5):675–86.PubMedCentralPubMedCrossRef
27.
28.
Biere SS, Maas KW, Cuesta MA, van der Peet DL. Cervical or thoracic anastomosis after esophagectomy for cancer: a systematic review and meta-analysis. Dig Surg. 2011;28(1):29–35.PubMedCrossRef
29.
Shiozaki A, Fujiwara H, Okamura H, et al. Risk factors for postoperative respiratory complications following esophageal cancer resection. Oncol Lett. 2012;3(4):907–12.PubMedCentralPubMed
30.
Aminian A, Panahi N, Mirsharifi R, et al. Predictors and outcome of cervical anastomotic leakage after esophageal cancer surgery. J Cancer Res Ther. 2011; 7(4): 448–53.PubMedCrossRef
31.
Radons J, Mulfhoff G. Immunostimulatory functions of membrane-bound and exported heat shock protein 70. Exerc Immunol Rev. 2005;11:17–33.PubMed
32.
Michelet P, Journo XBD, Roch A, et al. Perioperative risk factors for anastomotic leakage after esophagectomy. Chest. 2005;128(5):3461–6.PubMedCrossRef
33.
Miyazaki T, Kuwano H, Kato H, Yoshikawa M, Ojima H, Tsukada K. Predictive value of blood flow in the gastric tube in anastomotic insufficiency after thoracic esophagectomy. World J Surg. 2002;26(11):1319–23.PubMedCrossRef
34.
Ikeda Y, Niimi M, Kan S, et al. Clinical significance of tissue blood flow during esophagectomy by laser Doppler flowmetry. J Thorac Cardiovasc Surg. 2001;122(6):1101–6.PubMedCrossRef
35.
Kimura Y, Yamada K, Sakai T, et al. The regulatory role of heat shock protein 70-reactive CD4 + T cells during rat listeriosis. Int Immunol. 1998;10(2):117–30.PubMedCrossRef
36.
Tanaka S, Kimura Y, Mitani A, et al. Activation of T cell recognizing an epitope of heat shock protein 70 can protect against rat adjuvant arthritis. J Immunol. 1999;163(10):5560–5.PubMed
37.
Paliwal PK, Bansal A, Sagi SS, Sairam M. Intraperitoneal immunization of recombinant HSP70 (DnaK) of Salmonella typhi induces a predominant Th2 response and protective immunity in mice against lethal Salmonella infection. Vaccine. 2011;29(38):6532–9.PubMedCrossRef
38.
Fujibayashi T, Hashimoto N, Jijiwa M, Hasegawa Y, Kojima T, Ishiguro N. Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model. BMC Pulm Med. 2009; 9: 45.PubMedCentralPubMedCrossRef
39.
Yanaka A, Zhang S, Sato D, et al. Geranylgeranylacetone protects the human gastric mucosa from diclofenac-induced injury via induction of heat shock protein 70. Digestion. 2007;75(2–3):148–55.PubMedCrossRef
40.
Yu WY, Chuang TF, Guichard C, et al. Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model. Vaccine. 2011;29(18):3489–500.PubMedCrossRef
41.
Chen W, Lin Y, Liao C, Hsieh S. Modulatory effects of the human heat shock protein 70 on DNA vaccination. J Biomed Sci. 2000;7(5):412–9.PubMedCrossRef
Metadaten
Titel
Significant relationship between preoperative serum concentration of anti-heat shock protein 70 antibody and postoperative morbidity in patients with esophageal cancer
verfasst von
M. Nakajima, MD, PhD, FACS
H. Kato, MD, PhD, FACS
M. Sakai, MD, PhD
A. Sano, MD, PhD
T. Miyazaki, MD, PhD, FACS
M. Sohda, MD, PhD
T. Inose, MD, PhD
T. Yokobori, MD, PhD
N. Tanaka, MD, PhD
S. Suzuki, MD
N. Masuda, MD, PhD
M. Fukuchi, MD, PhD
H. Kuwano, MD, PhD, FACS
Publikationsdatum
01.06.2015
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 3/2015
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-015-0317-9

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