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Erschienen in: Wiener klinische Wochenschrift 5-6/2017

01.03.2017 | original article

Recent trends in the distribution of causative diseases of fever of unknown origin

verfasst von: Jin Shang, Libo Yan, Lingyao Du, Lingbo Liang, Qiaoling Zhou, Tao Liang, Lang Bai, Hong Tang

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 5-6/2017

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Summary

Fever of unknown origin is a challenging diagnostic problem and the aim of this research was to analyze trends in the distribution of its causative diseases. This retrospective study makes a comparison between two different clinical series of patients from two different periods: 227 from period 1 (1998–2002) and 602 from period 2 (2008–2012). There were fewer infections (31.72% vs.16.45%) and more miscellaneous causes (5.29% vs. 13.12%) in the period 2 series, whereas no significant differences in autoimmune diseases, malignancies and undiagnosed cases were found. Adult onset Still’s disease and lymphoma occupied the largest proportion in autoimmune diseases (75.00%) and malignancies (89.81%), respectively. Interestingly, the autoimmune diseases group, instead of infections, was found to be the leading category of the causative diseases in fever of unknown origin, which is contrary to previous reports. Further, adult onset Still’s disease and lymphoma were suggested to be valued more highly in view of the large and rising proportions found in this study. These trends could support the diagnosis and treatment of fever of unknown origin better in the future.
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Metadaten
Titel
Recent trends in the distribution of causative diseases of fever of unknown origin
verfasst von
Jin Shang
Libo Yan
Lingyao Du
Lingbo Liang
Qiaoling Zhou
Tao Liang
Lang Bai
Hong Tang
Publikationsdatum
01.03.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 5-6/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-1159-6