Skip to main content


Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.03.2017 | case report | Ausgabe 5-6/2017

Wiener klinische Wochenschrift 5-6/2017

Middle ear adenoma with neuroendocrine differentiation

A pediatric case report

Wiener klinische Wochenschrift > Ausgabe 5-6/2017
MD Elisabeth Sterrer, MD Franz Windisch, MD Kurt Frey, MD Klaus Rettensteiner, MD Benjamin Loader



Middle ear adenoma with neuroendocrine differentiation (MEA-ND), also known as carcinoid tumor of the middle ear, is an extremely rare neoplasm, especially when located within the tympanic cavity. To the best of our knowledge, this represents the first pediatric case of a MEA-ND described in Europe. Excluding the present case, only three other pediatric cases of this disease have been published globally.

Case report

We report on a 15-year-old female patient who presented with conductive hearing loss of the right ear. A tympanogram was flat. Ear microscopy revealed bulging of the right posterior superior tympanic quadrant. Computed tomography depicted an opacification of the middle ear and mastoid air cells without evidence of bone erosion. Paracentesis was performed assuming a serous otitis media. Since there was no liquid found the patient underwent an atticoantrotomy and mastoidectomy as therapy for cholesteatoma. Histologic examination revealed a highly differentiated neuroendocrine tumor. Immunohistochemical evaluation showed strong positivity for synaptophysin. On the basis of these results, the patient underwent a middle ear revision surgery. After 15 months, magnetic resonance imaging and octreotide scans suggested disease recurrence, prompting a second surgical revision. The histologic examination confirmed a recurrence of only 1 mm, but postoperative imaging still showed pathological diffuse enhancement. Eight years after the initial diagnosis there has been no evidence of recurrence or metastasis.


In our opinion a pathological radiological result is insufficient to identify recurrent or residual disease within the tympanic cavity.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:

Abo für kostenpflichtige Inhalte

Über diesen Artikel

Weitere Artikel der Ausgabe 5-6/2017

Wiener klinische Wochenschrift 5-6/2017 Zur Ausgabe

mitteilungen der gesellschaft der ärzte in wien


MUW researcher of the month

MUW researcher of the month