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Erschienen in: Wiener klinische Wochenschrift 17-18/2016

01.09.2016 | original article

Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities

verfasst von: MD Jana Figurová, MD, PhD Ingrid Dravecká, MD, PhD Martin Javorský, MD, PhD Jana Petríková, MD, FRCP, PhD Prof. Ivica Lazúrová

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 17-18/2016

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Summary

Objective

To investigate prevalence of vitamin D deficiency and its relation to clinical, anthropometrical, and biochemical findings in polycystic ovary syndrome (PCOS) and controls.

Design

Case-control prospective observational study.

Settings

Department of Internal medicine, L.P. University hospital.

Patient(s)

99 PCOS women and 66 controls.

Main outcome measure(s)

25-hydroxyvitamin D level (25(OH)D), anthropometric, endocrine, and metabolic parameters in both groups.

Results

There was no significant difference in 25(OH)D levels between PCOS women and controls (24.79 ± 10.77 vs 25.07 ± 10.14 ng/ml, p = 0.868) and also in the prevalence of 25(OH)D deficiency in both groups (80 vs 70 %; p = 0.138). Vitamin D-deficient PCOS patients had significantly higher body mass index (BMI), fasting insulin, and homeostasis model assessment-insulin resistance (median [quartiles]: 2.24 [1.38; 3.51] vs 1.23 [0.79; 1.66]; p< 0.05, age-and BMI-adjusted p = 0.036) and borderline higher glycemia (4.7 ± 0.5 vs 4.5 ± 0.4 mmol/l; p = 0.05; p_adj = 0.95) compared with vitamin D-deficient controls. PCOS women with metabolic syndrome (MS) had lower serum 25(OH)D compared with those without MS (20.6 ± 8.3 vs 25.9 ± 11.3 ng/ml, p = 0.049). 25(OH)D correlated positively with high-density lipoprotein cholesterol in all subjects (r = 0.159, p = 0.043) and negatively with luteinizing hormone/follicle-stimulating hormone ratio (r = − 0.211, p = 0.037).

Conclusion

Insulin resistance and other metabolic abnormalities in PCOS women seem to be related to PCOS rather than to vitamin D deficiency.
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Metadaten
Titel
Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities
verfasst von
MD Jana Figurová
MD, PhD Ingrid Dravecká
MD, PhD Martin Javorský
MD, PhD Jana Petríková
MD, FRCP, PhD Prof. Ivica Lazúrová
Publikationsdatum
01.09.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 17-18/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0768-9