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Erschienen in: Wiener klinische Wochenschrift 11-12/2020

28.04.2020 | original article

Plasma lipids in patients with inflammatory bowel disease

Observations on the associations between lipid indices and coronary flow reserve

verfasst von: MD Şeref Kul, MD Zuhal Çalışkan, MD Tolga Sinan Güvenç, MD Rengin Çetin Güvenç, MD Mustafa Çalışkan

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 11-12/2020

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Summary

Background and aims

Patients with inflammatory bowel disease (IBD) are at increased risk for coronary artery disease (CAD), even after adjusting for traditional risk factors for atherosclerosis. While inflammation is widely regarded as the pathophysiologic link between IBD and CAD, the exact mechanisms are largely unknown. This study was conducted to investigate the association of lipid parameters and indices with coronary flow reserve and markers of inflammation in IBD patients.

Methods

A total of 73 patients with IBD and 26 healthy controls were enrolled. Patients in the IBD arm were either in remission or had mild disease activity. Lipid parameters, C‑reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were analyzed using standard laboratory techniques. Coronary flow reserve (CFR) was measured using two-dimensional echocardiography.

Results

Both CRP and ESR were higher and CFR was significantly lower in IBD patients, but there were no differences in terms of lipid parameters or indices; however, patients with IBD and a CFR <2.0 had significantly higher triglyceride (TG) level (155.0 (80.0) mg/dl vs. 108.0 (68.0) mg/dl, p < 0.001) and there was a strong trend towards lower high-density lipoprotein (HDL) cholesterol (40.0 (8.5) mg/dl vs. 45.0 (10.0) mg/dl, p = 0.05) level in the latter group when compared to patients with a CFR ≥2.0. The atherogenic index of plasma (AIP), measured as log(TG/HDL-C) had the best predictive value for CFR in IBD group and was an independent predictor of CFR after multivariate adjustment for confounders (unstandardized coefficient: −0.75, 95% CI: (−1.13)–(−0.37)), β = −0.41, p = <0.001).

Conclusion

The atherogenic index of plasma is a marker for reduced CFR in IBD patients and could be useful to screen those at risk for early atherogenesis and CAD.
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Metadaten
Titel
Plasma lipids in patients with inflammatory bowel disease
Observations on the associations between lipid indices and coronary flow reserve
verfasst von
MD Şeref Kul
MD Zuhal Çalışkan
MD Tolga Sinan Güvenç
MD Rengin Çetin Güvenç
MD Mustafa Çalışkan
Publikationsdatum
28.04.2020
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 11-12/2020
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-020-01649-2