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01.12.2016 | original article | Ausgabe 23-24/2016

Wiener klinische Wochenschrift 23-24/2016

Orosomucoid is an independent predictor of prognosis in chronic heart failure

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 23-24/2016
Autoren:
MD Petra Kaplan, MD PhD Prof. Dr. Bojan Vrtovec, MD PhD Assist. Prof. Borut Jug

Summary

Background

Heart failure is associated with low-grade inflammation. In the present study we sought to assess the prognostic impact of orosomucoid, a marker of inflammation, in outpatients with heart failure.

Methods

In outpatients with chronic heart failure (no change in clinical status and/or therapy >3 months prior to inclusion), baseline levels of orosomucoid were determined. Clinical follow-up was obtained and the rate of heart failure-related deaths and hospitalisations recorded.

Results

A total of 134 patients (median age 71, 33.3 % female, mean left ventricular ejection fraction [LVEF] 36 %) were included. During a median follow-up of 695 (456–811) days, 54 patients (40.1 %) experienced an event. On Cox multivariate analysis, orosomucoid levels above the median (>497 mg/l) emerged as an independent predictor of prognosis (hazard ratio = 2.86, 95 % confidence interval 1.48–5.52 after adjusting for age, gender, ischaemic vs. non-ischaemic aetiology, LVEF, NT-proBNP and NYHA class).

Conclusion

Orosomucoid levels are an independent predictor of heart failure-related mortality and hospitalisations in patients with chronic heart failure.

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