Orosomucoid is an independent predictor of prognosis in chronic heart failure
- 01.12.2016
- original article
Erschienen in:
- Verfasst von
- Petra Kaplan, MD
- Prof. Dr. Bojan Vrtovec, MD PhD
- Assist. Prof. Borut Jug, MD PhD
- Erschienen in
- Wiener klinische Wochenschrift | Ausgabe 23-24/2016
Summary
Background
Heart failure is associated with low-grade inflammation. In the present study we sought to assess the prognostic impact of orosomucoid, a marker of inflammation, in outpatients with heart failure.
Methods
In outpatients with chronic heart failure (no change in clinical status and/or therapy >3 months prior to inclusion), baseline levels of orosomucoid were determined. Clinical follow-up was obtained and the rate of heart failure-related deaths and hospitalisations recorded.
Results
A total of 134 patients (median age 71, 33.3 % female, mean left ventricular ejection fraction [LVEF] 36 %) were included. During a median follow-up of 695 (456–811) days, 54 patients (40.1 %) experienced an event. On Cox multivariate analysis, orosomucoid levels above the median (>497 mg/l) emerged as an independent predictor of prognosis (hazard ratio = 2.86, 95 % confidence interval 1.48–5.52 after adjusting for age, gender, ischaemic vs. non-ischaemic aetiology, LVEF, NT-proBNP and NYHA class).
Conclusion
Orosomucoid levels are an independent predictor of heart failure-related mortality and hospitalisations in patients with chronic heart failure.
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- Titel
- Orosomucoid is an independent predictor of prognosis in chronic heart failure
- Verfasst von
-
Petra Kaplan, MD
Prof. Dr. Bojan Vrtovec, MD PhD
Assist. Prof. Borut Jug, MD PhD
- Publikationsdatum
- 01.12.2016
- Verlag
- Springer Vienna
- Erschienen in
-
Wiener klinische Wochenschrift / Ausgabe 23-24/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671 - DOI
- https://doi.org/10.1007/s00508-016-1034-5
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