Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.12.2016 | original article | Ausgabe 23-24/2016

Wiener klinische Wochenschrift 23-24/2016

Perioperative erythropoietin protects the CNS against ischemic lesions in patients after open heart surgery

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 23-24/2016
Autoren:
MD Nikola Lakič, MD Miha Mrak, MD Miha Šušteršič, MD PhD Peter Rakovec, MD PhD Prof. Matjaž Bunc

Summary

Aim

The aim of this study was to establish erythropoietin as a protective factor against brain ischemia during open heart surgery.

Methods

A total of 36 consecutive patients scheduled for revascularization heart surgery were included in the study. Of the patients 18 received 3 intravenous doses of recombinant human erythropoietin (rHuEpo, 24,000 IU) and 18 patients received a placebo. Magnetic resonance imaging (MRI) to detect new brain ischemic lesions was performed. Additionally, S100A, S100B, neuron-specific enolase A and B (NSE-A and B) and the concentration of antibodies against N‑methyl-D-aspartate receptors (NMDAR) to identify new neurological complications were determined.

Results

Patients who received rHuEpo showed no postoperative ischemic changes in the brain on MRI images. In the control group 5 (27.8 %) new ischemic lesions were found. The NMDAR antibody concentration, S100A, S100B and NSE showed no significant differences between the groups for new cerebral ischemia. High levels of lactate before and after external aortic compression (p = 0.022 and p = 0.048, respectively) and duration of operation could predict new ischemic lesions (p = 0.009).

Conclusions

The addition of rHuEpo reduced the formation of lesions detectable by MRI in the brain and could be used clinically as neuroprotection in cardiac surgery.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 23-24/2016

Wiener klinische Wochenschrift 23-24/2016 Zur Ausgabe

editorial

Editorial

mitteilungen der gesellschaft der ärzte in wien

Veranstaltungen