Sie können Operatoren mit Ihrer Suchanfrage kombinieren, um diese noch präziser einzugrenzen. Klicken Sie auf den Suchoperator, um eine Erklärung seiner Funktionsweise anzuzeigen.
Findet Dokumente, in denen beide Begriffe in beliebiger Reihenfolge innerhalb von maximal n Worten zueinander stehen. Empfehlung: Wählen Sie zwischen 15 und 30 als maximale Wortanzahl (z.B. NEAR(hybrid, antrieb, 20)).
Findet Dokumente, in denen der Begriff in Wortvarianten vorkommt, wobei diese VOR, HINTER oder VOR und HINTER dem Suchbegriff anschließen können (z.B., leichtbau*, *leichtbau, *leichtbau*).
A 51-year-old woman was admitted to the emergency department after a fall down the stairs. After physical examination, radiographic images were taken to rule out fractures. Noncontrast computed tomography revealed a well-circumscribed, mildly sclerotic lesion at the level of the trochanter major on the lateral aspect of the right thigh (Fig. 1a, arrow). In the patient, who did not have any clinical symptoms at the lesion level, further examination of the lesion was planned under elective conditions. Magnetic resonance imaging revealed a subcortically located lesion at the level of the right greater trochanter, an intermediate signal on T1-weighted images (Fig. 1b, arrow) and showing peripheral contrast enhancement in a post-contrast series (Fig. 1c, arrow). Due to the abnormal radiological nonspecific appearance of the lesion, bone scintigraphy was performed to evaluate whether the lesion was solitary and physiologically active. The bone scan images showed increased Tc-99m methylene diphosphonate activity at the same location in the femur (Fig. 1d, arrow). Additionally, bone scintigraphy showed bilateral involvement in the mandible (Fig. 1d, arrowheads). At our radiology clinic a biopsy was suggested, stating that the lesion had many differential diagnoses such as metastasis and lymphoma. A CT-guided biopsy identified the lesion as an intraosseous hibernoma (Fig. 2).
Fig. 1
a Coronal noncontrast computed tomography of the thigh shows a well-circumscribed, mildly sclerotic lesion at the level of the greater trochanter (arrow). b Coronal T1-weighted magnetic resonance imaging shows a well-defined lesion with intermediate signal (arrow). c Coronal postcontrast magnetic resonance imaging shows a lesion with peripheral contrast enhancement (arrow). d Bone scintigraphy shows areas of involvement in the femur (arrow) and bilateral mandible (arrowheads).
a Hematoxylin and eosin (4x magnification) stained histopathology image revealed tumor cells with large cytoplasm, numerous small clear vacuoles in thecytoplasm, centrally located nuclei with notches in the nucleus, as well as hematopoietic cells among bone trabeculae. b In immunohistochemical studies (4x magnification), tumor cells showed positive immune reaction with S100 and negative immune reaction with CD68, panCK, CDK4, MDM2
