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Erschienen in: Wiener klinische Wochenschrift 9-10/2018

07.12.2017 | original article

Epilepsy surgery in infants

Safety issues and developmental outcome

verfasst von: Gudrun Gröppel, Christian Dorfer, Anastasia Dressler, Angelika Mühlebner, Barbara Porsche, Thomas Czech, Daniela Prayer, Univ. Prof. Dr. Martha Feucht

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2018

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Summary

Purpose

To evaluate the efficacy and safety of epilepsy surgery in infants.

Methods

Included were patients with epilepsy onset during the first year of life, epilepsy surgery before the age of 36 months at the study center and a minimum follow-up of 24 months after surgery. Patients who were surgically treated before the age of 12 months were compared with those between 13 and 36 months. Group differences with respect to efficacy (seizure outcomes and developmental progress measured by the social interaction quotient, SIQ) as well as safety (i. e. peri-operative complication rates) were analyzed.

Results

A total of 20 patients (10 girls) were included: 10 (five girls) were operated on as infants (median age at surgery 9.0 months, median disease duration prior to surgery 5.0 months) and 10 (5 girls) were operated on as toddlers (median age at surgery 24.0 months, median disease duration prior to surgery 18.0 months). Favorable seizure outcomes (Wieser 1a and 1) were seen in 80% (8/10) of the infants and 60.0% (6/10) of toddlers. Developmental progress was most evident in infants who were seizure-free and off medication (median SIQ 85.5 versus 63.0 in the toddler group). There were no differences between the two groups with respect to safety aspects.

Conclusion

Despite several limitations due to the small number of patients included, our results are in favor of early epilepsy surgery in infants with drug-resistant epilepsy.
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Metadaten
Titel
Epilepsy surgery in infants
Safety issues and developmental outcome
verfasst von
Gudrun Gröppel
Christian Dorfer
Anastasia Dressler
Angelika Mühlebner
Barbara Porsche
Thomas Czech
Daniela Prayer
Univ. Prof. Dr. Martha Feucht
Publikationsdatum
07.12.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 9-10/2018
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1294-8

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