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Erschienen in: European Surgery 2/2020

18.03.2019 | review

Diagnosis and treatment of microvascular invasion in hepatocellular carcinoma

verfasst von: MD, PhD Rui-Sheng Ke, MD, PhD Qiu-cheng Cai, MD Yong-tai Chen, MD Li-Zhi Lv, MD, PhD Yi Jiang

Erschienen in: European Surgery | Ausgabe 2/2020

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Summary

Background

Microvascular invasion (MVI) is currently only confirmed by histopathological studies of surgical specimens. Preoperative diagnosis of MVI combined with clinical treatment is still a research problem and direction in hepatocellular carcinoma (HCC). How to assess the presence of MVI early and give appropriate treatment has become a research hotspot.

Methods

This review focuses on recent advances in MVI-related research, including the use of serum markers, tumor tissue markers, and new imaging techniques to predict MVI, as well as the molecular biology mechanisms and therapeutic advances in MVI.

Results

The emergence of MVI may be caused by the interaction of many complex biological processes and various pathogenic factors. We need to try to select several risk factors and establish a systematic evaluation method to solve their respective deficiencies, so as to provide more practical applications for the preoperative prediction of MVI program. Simultaneously, the preoperative, intraoperative, and postoperative comprehensive treatment strategies for MVI are particularly important.

Conclusion

The presence of MVI is thought to reflect increased capacity for local infiltration and distant metastases and affects the prognosis of HCC patients. To accurately assess MVI early based on some biomarkers prior to surgery, we need to work hard to explore and integrate various treatments to create a personalized treatment plan for MVI.
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Metadaten
Titel
Diagnosis and treatment of microvascular invasion in hepatocellular carcinoma
verfasst von
MD, PhD Rui-Sheng Ke
MD, PhD Qiu-cheng Cai
MD Yong-tai Chen
MD Li-Zhi Lv
MD, PhD Yi Jiang
Publikationsdatum
18.03.2019
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 2/2020
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-019-0573-1