Cyclic vomiting syndrome (CVS) is a functional disorder that can occur in all age groups. It is characterized by recurrent stereotypic episodes of nausea and vomiting. Between these episodes are nausea-free intervals. Lack of awareness leads often to delay in making the correct diagnosis. A specific test to identify patients with CVS is still missing. The correct diagnosis is based on the typical anamnestic report and the exclusion of other disorders that are associated with recurrent vomiting. Treatment of acute vomiting episode comprises antiemetic, antimigraine and sedative therapy. For prophylaxis of vomiting episodes, amitriptyline and propranolol are frequently used.