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Wiener Medizinische Wochenschrift

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05.07.2016 | brief report

Cutaneous Langerhans cell histiocytosis

The spectrum of a rare cutaneous neoplasia

verfasst von: Prof. Dr. Uwe Wollina, Dana Langner, Gesina Hansel, Jacqueline Schönlebe

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 9-10/2018

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Summary

Langerhans cell histiocytosis (LCH) is a rare disorder that is now recognized as a true malignancy of dendritic Langerhans cells. Various somatic mutations have been discovered for BRAF and MAP kinases. The clinical variability is remarkable. A very rare variant is cutaneous LCH without internal organ manifestations. We present a case series of cutaneous LCH illustrating the spectrum of clinical symptoms, treatment, and disease course. Cutaneous LCH needs a careful investigation of possible internal involvement and a long follow-up since second malignancies may develop over time. Overtreatment should be avoided, since too-aggressive treatment will not improve the outcome.

Vorheriger Artikel Psychosocial aspects associated with use of sunscreen, natural sunlight exposure, and artificial tanning

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Titel: Cutaneous Langerhans cell histiocytosis
The spectrum of a rare cutaneous neoplasia
verfasst von: Prof. Dr. Uwe Wollina
Dana Langner
Gesina Hansel
Jacqueline Schönlebe
Publikationsdatum: 05.07.2016
Verlag: Springer Vienna
Erschienen in: Wiener Medizinische Wochenschrift / Ausgabe 9-10/2018
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI: https://doi.org/10.1007/s10354-016-0460-3

Springer Medizin Österreich

Summary

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