Skip to main content


Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.01.2013 | case report | Ausgabe 1-2/2013

Wiener klinische Wochenschrift 1-2/2013

Complete remission after a single cycle of azacitidine in a case of relapsed acute myeloid leukemia

Wiener klinische Wochenschrift > Ausgabe 1-2/2013
MD Christine Valentiny, MSc Martina Mitrovic, MD, DI biomed.inf. Lisa Pleyer, MD Michael Steurer, MD Wolfgang Willenbacher, MD, MSc Assoc. Prof. Reinhard Stauder


A 75-year-old female patient presented with late relapse of acute myeloid leukemia (AML). She received a single cycle of azacitidine before refusing further treatment. Around 6 weeks after this single azacitidine cycle, complete remission—according to international working group criteria—was observed with continuous improvement in peripheral blood counts to normal values, transfusion-independence, normal blast count (< 5 %) with normal morphology and flow cytometry, as well as a normal bone marrow karyotype and no dysplastic stigmata suggestive of a coexisting myelodysplastic syndrome. The patient also showed a pronounced improvement in performance status. Seven months later a second relapse occurred, followed by one additional azacitidine cycle that showed only a transient and a minor increase in thrombocytes and granulocytes, corresponding to an international working group nonresponse. As azacitidine treatment was interrupted after a single cycle, this case gives insight into the kinetics of response. The lack of response to azacitidine in AML after the second relapse suggests that azacitidine administration should be maintained after response.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:

Abo für kostenpflichtige Inhalte

Über diesen Artikel

Weitere Artikel der Ausgabe 1-2/2013

Wiener klinische Wochenschrift 1-2/2013 Zur Ausgabe

mitteilungen der gesellschaft


mitteilungen der gesellschaft der ärzte in wien

Festabend: 175 Jahre Gesellschaft der Ärzte in Wien