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Erschienen in:

07.01.2019 | original report

Changes in patients’ quality of life during radiotherapy and 1 month after treatment

verfasst von: Osamu Tanaka, M.D., Yuka Kunishima, N.S., Takuya Taniguchi, M.P., Kousei Ono, M.P., Masayuki Matsuo, M.D.

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 1/2019

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Summary

Background

The EORTC QLQ-C30 quality of life (QOL) questionnaire is designed to measure cancer patients’ physical, psychological, and social functions. There are few reports on the impact of radiotherapy (RT) on QOL; thus, we investigated QOL changes during the RT period and 1 month after RT.

Methods

We scored EORTC QLQ-C30 (version 3.0) questionnaires from 66 patients. The questionnaire contained 30 items, including 1 item on financial concerns, a global health domain, 5 functional domains, 3 symptom domains, and 5 single-symptom items. Assessments were performed before RT, at the end of the day after RT, and 1 month after RT. Correlations between the patients’ characteristics (e.g., age, sex, organ, RT response) and QOL change were evaluated.

Results

No specific patient characteristic significantly correlated with a QOL change during RT. In 15 QLQ-C30 items, those items in which the change in score achieved statistical significance (P < 0.05) were the following: physical function was improved from the end of RT to 1 month after RT; role function worsened from the end of RT to 1 month after RT; and emotional function worsened from the start of RT to 1 month after RT.

Conclusions

The QOL was poorest at the end of RT. If treatment was completed, physical function improved, but role function and emotional function worsened just 1 month after treatment. For role and emotional function, observation by medical staff is necessary.
Literatur
1.
Zurück zum Zitat Kaasa S, Bjordal K, Aaronson N, Moum T, Wist E, Hagen S, et al. The EORTC core quality of life questionnaire (QLQ-C30): validity and reliability when analysed with patients treated with palliative radiotherapy. Eur J Cancer. 1995;31(3):2260–3.CrossRef Kaasa S, Bjordal K, Aaronson N, Moum T, Wist E, Hagen S, et al. The EORTC core quality of life questionnaire (QLQ-C30): validity and reliability when analysed with patients treated with palliative radiotherapy. Eur J Cancer. 1995;31(3):2260–3.CrossRef
3.
Zurück zum Zitat Kotronoulas G, Kearney N, Maguire R, Harrow A, Di Domenico D, Croy S, et al. What is the value of the routine use of patient-reported outcome measures toward improvement of patient outcomes: processes of care, and health service outcomes in cancer care? A systematic review of controlled trials. J Clin Oncol. 2014;32(14):1480–501.CrossRef Kotronoulas G, Kearney N, Maguire R, Harrow A, Di Domenico D, Croy S, et al. What is the value of the routine use of patient-reported outcome measures toward improvement of patient outcomes: processes of care, and health service outcomes in cancer care? A systematic review of controlled trials. J Clin Oncol. 2014;32(14):1480–501.CrossRef
4.
Zurück zum Zitat Basch E, Deal AM, Kris MG, Scher HI, Hudis CA, et al. Symptom monitoring with patient-reported outcomes during routine cancer treatment: a randomized controlled trial. J Clin Oncol. 2016;34(6):557–65.CrossRef Basch E, Deal AM, Kris MG, Scher HI, Hudis CA, et al. Symptom monitoring with patient-reported outcomes during routine cancer treatment: a randomized controlled trial. J Clin Oncol. 2016;34(6):557–65.CrossRef
5.
Zurück zum Zitat Valderas JM, Kotzeva A, Espallargues M, Guyatt G, Ferrans CE, Halyard MY, et al. The impact of measuring patient-reported outcomes in clinical practice: a systematic review of the literature. Qual Life Res. 2008;17(2):179–93.CrossRef Valderas JM, Kotzeva A, Espallargues M, Guyatt G, Ferrans CE, Halyard MY, et al. The impact of measuring patient-reported outcomes in clinical practice: a systematic review of the literature. Qual Life Res. 2008;17(2):179–93.CrossRef
6.
Zurück zum Zitat Snyder CF, Aaronson NK. Use of patient-reported outcomes in clinical practice. Lancet. 2009;374(9687):369–70.CrossRef Snyder CF, Aaronson NK. Use of patient-reported outcomes in clinical practice. Lancet. 2009;374(9687):369–70.CrossRef
7.
Zurück zum Zitat Velikova G, Booth L, Smith AB, Brown PM, Lynch P, Brown JM, et al. Measuring quality of life in routine oncology practice improves communication and patient well-being: a randomized controlled trial. J Clin Oncol. 2004;22(4):714–24.CrossRef Velikova G, Booth L, Smith AB, Brown PM, Lynch P, Brown JM, et al. Measuring quality of life in routine oncology practice improves communication and patient well-being: a randomized controlled trial. J Clin Oncol. 2004;22(4):714–24.CrossRef
8.
Zurück zum Zitat Detmar SB, Muller MJ, Schornagel JH, Wever LDV, Aaronson NK. Health-related quality-of-life assessments and patient-physician communication. a randomized clinical trial. JAMA. 2002;288(23):3027–34.CrossRef Detmar SB, Muller MJ, Schornagel JH, Wever LDV, Aaronson NK. Health-related quality-of-life assessments and patient-physician communication. a randomized clinical trial. JAMA. 2002;288(23):3027–34.CrossRef
9.
Zurück zum Zitat Nordin K, Stecl J, Hoffman K, Glimelius B. Alternative methods of interpreting quality of life data in advanced gastrointestinal cancer patients. Br J Cancer. 2001;85(9):1265–72.CrossRef Nordin K, Stecl J, Hoffman K, Glimelius B. Alternative methods of interpreting quality of life data in advanced gastrointestinal cancer patients. Br J Cancer. 2001;85(9):1265–72.CrossRef
10.
Zurück zum Zitat Cleeland CS, Wang XS, Shi Q, Mendoza TR, Wright SL, Berry MD, et al. Automated symptom alerts reduce postoperative symptom severity after cancer surgery: a randomized controlled clinical trial. J Clin Oncol. 2011;29(8):994–1000.CrossRef Cleeland CS, Wang XS, Shi Q, Mendoza TR, Wright SL, Berry MD, et al. Automated symptom alerts reduce postoperative symptom severity after cancer surgery: a randomized controlled clinical trial. J Clin Oncol. 2011;29(8):994–1000.CrossRef
11.
Zurück zum Zitat Osoba D, Zee B, Warr D, Latreille J, Kaizer L, Pater J. Effect of postchemotherapy nausea and vomiting on health-related quality of life. Support Care Cancer. 1997;5(4):307–13.CrossRef Osoba D, Zee B, Warr D, Latreille J, Kaizer L, Pater J. Effect of postchemotherapy nausea and vomiting on health-related quality of life. Support Care Cancer. 1997;5(4):307–13.CrossRef
12.
Zurück zum Zitat Cameron MG, Kersten C, van Helvoirt R, Rohde G, Fosså SD, Vistad I. Patient reported outcomes of symptoms and quality of life among cancer patients treated with palliative pelvic radiation: a pilot study. BMC Res Notes. 2011;4(1):252.CrossRef Cameron MG, Kersten C, van Helvoirt R, Rohde G, Fosså SD, Vistad I. Patient reported outcomes of symptoms and quality of life among cancer patients treated with palliative pelvic radiation: a pilot study. BMC Res Notes. 2011;4(1):252.CrossRef
13.
Zurück zum Zitat King-Kallimanis BL, Ter Hoeven CL, de Haes HC, Smets EM, Koning CC, Oort FJ. Assessing measurement invariance of a health-related quality-of-life questionnaire in radiotherapy patients. Qual Life Res. 2012;21(10):1745–53.CrossRef King-Kallimanis BL, Ter Hoeven CL, de Haes HC, Smets EM, Koning CC, Oort FJ. Assessing measurement invariance of a health-related quality-of-life questionnaire in radiotherapy patients. Qual Life Res. 2012;21(10):1745–53.CrossRef
14.
Zurück zum Zitat Jand M, Johnson D, Woelfl H, Trimmel M, Bressmann T, Schröckmayr H, et al. Measurement of quality of life in head and neck cancer patients utilizing the quality of life radiation therapy questionnaire. Strahlenther Onkol. 2002;178(3):153–8.CrossRef Jand M, Johnson D, Woelfl H, Trimmel M, Bressmann T, Schröckmayr H, et al. Measurement of quality of life in head and neck cancer patients utilizing the quality of life radiation therapy questionnaire. Strahlenther Onkol. 2002;178(3):153–8.CrossRef
15.
Zurück zum Zitat Lo PS, Lo SK, Tong MC, Ku PK, Leung SF, van Hasselt CA. Quality-of-life measurement in patients undergoing radiation therapy for head and neck cancer: a Hong Kong experience. J Oncol Manag. 2004;13(6):13–23.PubMed Lo PS, Lo SK, Tong MC, Ku PK, Leung SF, van Hasselt CA. Quality-of-life measurement in patients undergoing radiation therapy for head and neck cancer: a Hong Kong experience. J Oncol Manag. 2004;13(6):13–23.PubMed
16.
Zurück zum Zitat Trotti A, Johnson DJ, Gwede C, Casey L, Sauder B, Cantor A, et al. Development of a head and neck companion module for the quality of life-radiation therapy instrument (QOL-RTI). Int J Radiat Oncol Biol Phys. 1998;42(2):257–61.CrossRef Trotti A, Johnson DJ, Gwede C, Casey L, Sauder B, Cantor A, et al. Development of a head and neck companion module for the quality of life-radiation therapy instrument (QOL-RTI). Int J Radiat Oncol Biol Phys. 1998;42(2):257–61.CrossRef
Metadaten
Titel
Changes in patients’ quality of life during radiotherapy and 1 month after treatment
verfasst von
Osamu Tanaka, M.D.
Yuka Kunishima, N.S.
Takuya Taniguchi, M.P.
Kousei Ono, M.P.
Masayuki Matsuo, M.D.
Publikationsdatum
07.01.2019
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 1/2019
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-018-0469-y