01.10.2015 | Short Communication
Selected commentary to “Treatment of Barrett’s esophagus with a novel focal cryoablation device: a safety and feasibility study”
Erschienen in: European Surgery | Ausgabe 5/2015
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Barrett’s esophagus (BE) is caused by gastroesophageal reflux disease (GERD) and harbors an increased risk for esophageal cancer [1‐3]. Via a sequence involving low- (LGD) and high-grade dysplasia (HGD), esophageal adenocarcinoma may develop (annual cancer risk: 0.1–0.7 %) [4, 5]. Indefinite for dysplasia (ID) defines a condition where the presence or absence of dysplasia cannot be accurately assessed, due to inflammatory changes in the mucosa. Re-endoscopy and biopsy sampling is recommended after a 3–4 weeks course of double dose proton pump inhibitor (PPI) therapy p.o. (i.e. 2 × 40 mg PPI). Diagnosis of BE is established if biopsies obtained from endoscopically visible segments, tongues or islands of columnar lined esophagus (CLE) contain goblet cells ± LGD, HGD or cancer [6]. …Anzeige