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Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen

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Schützt Vitamin D vor COVID-19? Eine beschreibende Übersicht

verfasst von: PD Dr. med. habil. Stephan H. Scharla

Erschienen in: Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen

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Zusammenfassung

Die vielfältigen Wirkungen von Vitamin D (bzw. Calcitriol) auf das Immunsystem und auf die Lunge lassen eine präventive und therapeutische Wirkung auf COVID-19 plausibel erscheinen. Epidemiologische Studien legen nahe, dass Vitamin-D-Mangel ein Risikofaktor für COVID-19 sein könnte, wobei eine Kausalität daraus noch nicht abgeleitet werden kann. Reverse Kausalität oder andere zugrunde liegende gemeinsame Ursachen (Alter, Adipositas) können einen Zusammenhang erklären.

Kontrollierte prospektive Studien haben für die Vitamin-D-Supplementation und -Therapie teilweise klinisch bedeutsame Effekte zur Infektionsprophylaxe und zur Abmilderung der Krankheitsverläufe gezeigt, jedoch konnte dies nicht durch alle Studien bestätigt werden. Fragen zur Auswahl von Risikogruppen und zum besten Dosierungsregime bleiben noch offen.

Infante M, Ricordi C, Sanchez J, Clare-Salzler MJ, Padilla N, Fuenmayor V, Chavez C, Alvarez A, Baidal D, Alejandro R, Caprio M, Fabbri A (2019) Influence of vitamin D on islet autoimmunity and beta-cell function in type 1 diabetes. Nutrients 11:2185. https://doi.org/10.3390/nu11092185 CrossRefPubMedPubMedCentral

Mathieu C (2011) Vitamin D and the immune system: getting it right. IBMS BoneKEy 8:178–186 CrossRef

Colin EM, Asmawidjaja PS, van Hamburg JP, Mus AM, van Driel M, Hazes JM, van Leeuwen JP, Lubberts E (2010) 1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis. Arthritis Rheum 62:132–142 CrossRefPubMed

Scharla SH (2021) Pleiotrope Wirkung von Vitamin D mit Berücksichtigung von COVID-19. J Miner Stoffwechs Muskuloskelet Erkrank 28:2–11 CrossRef

Bergmann P, Lindh AU, Björkhem-Bergman L, Lindh JD (2013) Vitamin D and respiratory tract infections: a systematic review and meta-analysis of randomized controlled trials. PLoS One 8:e65835 CrossRef

Martineau AR, Jolliffe DA, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Janssens W, Jensen ME, Kerley CP, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S, Stelmach I, Kumar GT, Uraschima M, Camargo CA, Griffiths CJ, Hooper RL (2019) Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis. Health Technol Assess 23:1–44 CrossRefPubMedPubMedCentral

Quesada-Gomez JM, Lopez-Miranda J, Entrenas-Castillo M, Casado-Diaz A, Solans XN, Mansur JL, Bouillon R (2022) Vitamin D endocrine system and COVID-19: treatment with calcifediol. Nutrients 14:2716. https://doi.org/10.3390/nu14132716 CrossRefPubMedPubMedCentral

Xu Y, Baylink DJ, Chen CS, Reeves ME, Xiao J, Lacy C, Lau E, Cao H (2020) The importance of vitamin D metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19. J Transl Med 18:322 CrossRefPubMedPubMedCentral

Mahdavi AM (2020) A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. Rev Med Virol 30:e2119. https://doi.org/10.1002/rmv.2119 CrossRef

10.

Jiang F, Yang Y, Xue L, Li B, Zhang Z (2017) 1a,25-dihydroxyvitamin D3 attenuates TGF-b-induced pro-fibrotic effects in human lung epithelial cells through inhibition of epithelial-mesenchymal transition. Nutrients 9:980. https://doi.org/10.3390/nu9090980 CrossRefPubMedPubMedCentral

11.

Evans RM, Lippman SM (2020) Shining light on the COVID-19 pandemic: a vitamin D receptor checkpoint in defense of unregulated wound healing. Cell Metab 32:704–709 CrossRefPubMedPubMedCentral

12.

Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, Mast AE, Justice A, Aronow B, Jacobson D (2020) A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm. Elife 9:e59177. https://doi.org/10.7554/eLife.59177 CrossRefPubMedPubMedCentral

13.

Hernandez JL, Nan D, Fernandez-Ayala M, Garcia-Unzueta M, Hernandez-Hernandez MA, Lopez-Hoyos M, Munoz-Ccho P, Omos JM, Gutierrez-Cuadra M, Ruiz-Cubillan JJ, Crespo J, Marinez-Taboada VM (2020) Vitamin D status in hospitalized patients with SARS-CoV‑2 infection. J Clin Endocrinol Metab. https://doi.org/10.1210/clinem/dgaa733 CrossRef

14.

Hutchings N, Babalyan V, Baghdasaryan S, Qefoyan M, Sargsyants N, Aghajanova E, Martirosyan A, Harutyunyan R, Lesnyak O, Formenti AM, Giustina A, Bilezikian JP (2021) Patients hospitalized with COVID-19 have low levels of 25-hydroxyvitamin D. Endocrine 16:1–3. https://doi.org/10.1007/s12020-020-02597-7 CrossRef

15.

Panagiotou G, Tee SA, Ihsan Y, Athar W, Marchitelli G, Kelly D, Boot CS, Stock N, Macfarlane J, Martineau AR, Burns G, Quinton R (2020) Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity. Clin Endocrinol 93:508–511 CrossRef

16.

Vassiliou AG, Jahaj E, Pratikaki M, Orfanos SE, Dimopoulou I, Kotanidou A (2020) Low 25-hydroxyvitamin D levels on admission to the intensive care unit may predispose COVID-19 pneumonia patients to a higher 28-day mortality risk: a pilot study on a greek ICU cohort. Nutrients 12:3773 CrossRefPubMedPubMedCentral

17.

Karahan S, Katkat F (2021) Impact of serum 25(OH)Vitamin D level on mortality in patients with COVID-19 in Turkey. J Nutr Health Aging 25:189–196 CrossRefPubMed

18.

Abrishami A, Dalili N, Torbati PM, Asgari R, Arab-Ahmadi M, Behnam B, Sanei-Taheri M (2020) Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study. Z Ernahrungswiss. https://doi.org/10.1007/s00394-020-02411-0 CrossRef

19.

Orchard L, Baldry M, Nasim-Mohi M, Monck C, Saeed K, Grocott MPW, Ahilanandan D, University Hospital Southampton Critical Care Team and the REACT COVID Investigators (2021) Vitamin D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients. Clin Chem Lab Med. https://doi.org/10.1515/cclm-2020-1567 CrossRefPubMed

20.

Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Boxberger M, Merle U (2020) Vitamin D deficiency and outcome of COVID-19 patients. Nutrients 12:2757. https://doi.org/10.3390/nu12092757 CrossRefPubMedPubMedCentral

21.

Pimentel GD, Dela Vega MCM, Pichard C (2021) Low vitamin D levels and increased neutrophil in patients admitted at ICU with COVID-19. Clin Nutr ESPEN 44:466–468 CrossRefPubMedPubMedCentral

22.

Jevalikar G, Mithal A, Singh A, Sharma R, Farooqui KJ, Mahendru S, Dewan A, Budhiraja S (2021) Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patiens hospitalized for COVID-19. Sci Rep 11:6259 CrossRef

23.

Merzon E, Tworowski D, Gorohovski A, Vinker S, Cohen AG, Green I, Frenkel-Morgenstern (2020) Low plasma 25(OH)vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. FEBS J 287:3693–3702 CrossRefPubMedPubMedCentral

24.

Hastie CE, Mackay DF, Ho F, Celis-Morales CA, Katikireddi SV, Niedzwiedz C, Jani BD, Welsh P, Mair FS, Gray SR, O’Donnell CA, Gill JMR, Sattar N, Pell JP (2020) Vitamin D concentrations and COVID-19 infection in UK biobank. Diabetes Metab Syndr 14:561–565 CrossRefPubMedPubMedCentral

25.

Dror AA, Morozov N, Daoud A, Namir Y, Yakir O, Shachar Y, Lifshitz M, Segal E, Fisher L, Mizrachi M, Eisenbach N, Rayan D, Gruber M, Bashkin A, Kaykov E, Barhoum M, Edelstein M, Sela E (2022) Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness. PLoS ONE 17(2):e263069. https://doi.org/10.1371/journal.pone.0263069 CrossRefPubMedPubMedCentral

26.

Mukherjee SB, Gorohovski A, Merzon E, Levy E, Mukherjee S, Frenkel-Morgenstern M (2022) Seasonal UV exposure and vitamin D: association with the dynamics of COVID-19 transmission in Europe. FEBS Open Bio 12:106–117 CrossRefPubMed

27.

Borsche L, Glauner B, von Mendel J (2021) COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3: results of a systematic review and meta-analysis. Nutrients 13:3596. https://doi.org/10.3390/nu13103596 CrossRefPubMedPubMedCentral

28.

Chiodini I, Gatti D, Soranna D, Merlotti D, Mingiano C, Fassio A, Adami G, Falchetti A, Eller-Vainicher C, Rossini M et al (2021) Vitamin D status and SARS-CoV‑2 infection and COVID-19 clinical outcomes. Front Public Health 9:736665 CrossRefPubMedPubMedCentral

29.

Dissanayake HA, de Silva NL, Sumanatilleke M, de Silva SDN, Gamage KKK, Dematapitiya C, Kuruppu DC, Ranasinghe P, Pathmanathan S, Katulanda P (2022) Prognostic and therapeutic role of vitamin D in COVID-19: systematic review and meta-analysis. J Clin Endocrinol Metab 107:1484–1502 CrossRefPubMed

30.

D’Ecclesiis O, Gavioli C, Martinoli C, Raimondi S, Chiocca S, Miccolo C, Bossi P, Cortinovis D, Chiaradonna F, Palorini R, Faciotti F, Bellerba F, Canova S, Jemos C, Sale EO, Gaeta A, Zerbato B, Gnagnarella P, Gandini S (2022) Vitamin D and SARS-CoV2 infection, severity and mortality: a systematic review and meta-analysis. PLoS ONE 17(7):e268396. https://doi.org/10.1371/journal.pone.0268396 CrossRefPubMedPubMedCentral

31.

Barrett R, Youssef M, Shah I, Ioana J, Lawati AA, Bukhari A, Hegarty S, Cormican LJ, Judge E, Burke CM, Cody C, Feely J, Hutchinson K, Tormey W, O’Neill E, O’Shea A, Connolly M, McCartney DMA, Faul JL (2022) Vitamin D status and mortality from SARS coV-2: a prospective study of unvaccinated caucasian adults. Nutrients 14:3252. https://doi.org/10.3390/nu14163252 CrossRefPubMedPubMedCentral

32.

Annweiler G, Corvaisier M, Gautier J, Dubee V, Legrand E, Sacco G, Annweiler C (2020) Vitamin D supplementation associated to better survival in hospitalized frail elderly COVID-19 patients. The GERIA-COVID quasi-experimental study. Nutrients 12:3377. https://doi.org/10.3390/nu12113377 CrossRefPubMedPubMedCentral

33.

Annweiler C, Hanotte B, Grandin de l’Eprevier C, Sabatier JM, Lafaie L, Célarier T (2020) Vitamin D and survival in COVID-19 patients: a quasi–experimental study. J Steroid Biochem Mol Biol 204:105771 CrossRefPubMedPubMedCentral

34.

Rastogi A, Bhansali A, Khare N, Suri V, Yaddanapudi N, Sachdeva N, Puri GD, Malhotra P (2020) Short term, high-dose vitamin D‑supplementation for COVID-19 disease: a randomized, placebo–controlled study (SHADE study). Postgrad Med J. https://doi.org/10.1136/postgradmedj-2020-139065 CrossRefPubMed

35.

Rawat D, Roy A, Maitra S, Shankar V, Khanna P, Baidya DK (2021) Vitamin D supplementation and COVID-19 treatment: a systematic review and meta-analysis. Diabetes Metab Syndr 15:102189 CrossRefPubMedPubMedCentral

36.

Migliorini F, Vaishya R, Eschweiler J, Oliva F, Hildebrand F, Maffulli N (2022) Vitamins C and D and COVID-19 susceptibility, severity and progression: an evidence based systematic review. Ann Univ Mariae Curie Sklodowska [Med] 58:941. https://doi.org/10.3390/medicina58070941 CrossRef

37.

Annweiler C, Beaudenon M, Gautier J, Gonsard J, Boucher S, Chapelet G, Darsonval A, Fougere B, Guerin O, Houvet M et al (2022) High-dose versus standard-dose vitamin D supplementation in older adults with COVID-19 (COVIT-TRIAL): a multicenter, open-label, randomized controlled superiority trial. PLoS Med 19:e1003999 CrossRefPubMedPubMedCentral

38.

Elamir YM, Amir H, Lim S, Rana YP, Lopez CG, Feliciano NV, Omar A, Grist WP, Via MA (2022) A randomized pilot study using calcitriol in hospitalized COVID-19 patients. Bone 154:116175 CrossRefPubMed

39.

Lakkireddy M, Gadiga SG, Malathi RD (2021) Impact of daily high dose oral vitamin D therapy on the inflammatory markers inpatients with COVID 19 disease. Sci Rep 11:10641 CrossRefPubMedPubMedCentral

40.

Entrenas Castillo M, Costa LME, Barrios JMV, Diaz JFA, Miranda JL, Bouillon R, Gomez JMQ (2020) Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: a pilot randomized clinical study. J Steroid Biochem Mol Biol 203:105751 CrossRefPubMedPubMedCentral

41.

Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF, Duran CSC, Silva CBR, Franco AS, Macedo MB, Dalmolin HHH et al (2021) Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19. JAMA 325:1053–1060 CrossRefPubMed

42.

Maghbooli Z, Sahraian MA, Jamalimoghadamsiahkali S, Asadi A, Zarei A, Zendehdel A, Varzandi T, Mohammadnabi S, Alijani N, Karimi M et al (2021) Treatment with 25-hydroxyvitamin D3 (calcifediol) is associated with a reduction in the blood neutrophil-to-lymphocyte ratio marker of disease severity in hospitalized patients with COVID-19: a pilot multicenter, randomized, placebo-controlled, double-blinded clinical trial. Endocr Pract 27:1242–1251 CrossRefPubMedPubMedCentral

43.

Villasis-Keever MA, Lopez-Alarcon MG, Miranda-Novales G, Zurita-Cruz JN, Vázquz AS, González-Ibarra J, Martínez-Reyes M, Grajales-Muniz C, Santacruz-Tinoco CE, Martínez-Miguel B, Maldonado-Hernández J, Cifuentes-González Y, Klünder-Klünder M, Garduno-Espinosa J, López-Martínez B, Parra-Ortega I (2022) Efficacy and safety of vitamin D supplementation to prevent COVID-19 in frontline healthcare workers. A randomized clinical trial. Arch Med Res 53:423–430 CrossRefPubMedPubMedCentral

44.

Jolliffe DA, Holt H, Greenig M, Talaei M, Perdek N, Pfeffer P, Vivaldi G, Maltby S, Symons J, Barlow NL, Normandale A, Garcha R, Richter AG, Faustini SE, Orton C, Ford D, Lyons RA, Davies GA, Kee F, Griffiths CJ, Norrie J, Sheikh A, Shaheen SO, Relton C, Martineau AR (2022) Effect of a test-and treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT). BMJ 378:e71230 CrossRefPubMed

Titel: Schützt Vitamin D vor COVID-19? Eine beschreibende Übersicht
verfasst von: PD Dr. med. habil. Stephan H. Scharla
Publikationsdatum: 26.05.2023
Verlag: Springer Vienna
Erschienen in: Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen
Print ISSN: 2412-8260
Elektronische ISSN: 2412-8287
DOI: https://doi.org/10.1007/s41970-023-00231-2

Springer Medizin Österreich

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Schützt Vitamin D vor COVID-19? Eine beschreibende Übersicht

Zusammenfassung

Springer Medizin Österreich

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Zusammenfassung

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