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Wiener klinische Wochenschrift

Erschienen in:

24.11.2022 | original article

Peculiarities of melatonin levels in preterm infants

verfasst von: Prof. Halyna Pavlyshyn, MD, PhD, Iryna Sarapuk, MD, PhD, Kateryna Kozak, MD, PhD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 5-6/2024

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Summary

Background

Melatonin plays an important role in organism functioning, child growth, and development. Of particular importance is melatonin for preterm infants. The aim of our research was to study the peculiarities of melatonin levels depending on various factors in preterm infants with gestational age (GA) of less than 34 weeks.

Methods

The study involved 104 preterm infants with GA less than 34 weeks who were treated in the neonatal intensive care unit (NICU). The level of melatonin in urine samples was determined by an enzyme-linked immunosorbent assay.

Results

Melatonin concentration was significantly lower in extremely and very preterm infants compared to moderate preterm (3.57 [2.10; 5.06] ng/ml vs. 4.96 [3.20; 8.42] ng/ml, p = 0.007) and was positively correlated with GA (Spearman r = 0.32; p < 0.001). Positive correlations were revealed between melatonin levels and Apgar scores at the 1st (Spearman r = 0.31; p = 0.001) and 5th minutes after birth (Spearman r = 0.35; p < 0.001). Melatonin levels were lower in newborns with respiratory distress syndrome (p = 0.011). No significant correlations were found between melatonin concentration and birth weight (Spearman r = 0.15; p = 0.130). There were no associations of melatonin concentrations and mode of delivery (p = 0.914), the incidence of early-onset sepsis (p = 0.370) and intraventricular hemorrhages (p = 0.501), and mechanical ventilation (p = 0.090). The results of multiple regression showed that gestational age at birth was the most significant predictor of melatonin level in preterm infants (B = 0.507; p = 0.001).

Conclusion

Gestational age and the Apgar score were associated with decreased melatonin levels in preterm infants. The level of melatonin in extremely and very preterm infants was lower compared to moderate preterm infants.

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Titel: Peculiarities of melatonin levels in preterm infants
verfasst von: Prof. Halyna Pavlyshyn, MD, PhD
Iryna Sarapuk, MD, PhD
Kateryna Kozak, MD, PhD
Publikationsdatum: 24.11.2022
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 5-6/2024
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-022-02109-9

Springer Medizin Österreich

Summary

Background

Methods

Results

Conclusion

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