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Journal für Gynäkologische Endokrinologie/Schweiz

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Erschienen in: Journal für Gynäkologische Endokrinologie/Schweiz 2/2019

05.06.2019 | Orthomolekulare Medizin

Magnesium – das unterschätzte Mineral

Rolle von Magnesium im Stoffwechsel und praktische Empfehlungen

verfasst von: Dr. Roland Stegmann

Erschienen in: Journal für Gynäkologische Endokrinologie/Schweiz | Ausgabe 2/2019

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Zusammenfassung

Neben seiner Funktion als Elektrolyt spielt Magnesium eine entscheidende Rolle im Stoffwechsel. Mehr als 700 Enzymsysteme benötigen Magnesium als Kofaktor. Von zentraler Bedeutung ist das Mineral für den Energiestoffwechsel. Zahlreiche Hormone und Neurotransmitter sowie alle Organe und Gewebe sind zum richtigen Funktionieren auf Magnesium angewiesen. Ein Mangel kann sich folglich in ganz unterschiedlichen Formen manifestieren, was seine Erkennung erschweren kann. Dutzende von Symptomen werden mit einem Magnesiummangel in Verbindung gebracht. Erhebungen lassen vermuten, dass Magnesiummangel in der Bevölkerung weiter verbreitet ist als bislang angenommen. Viele Ursachen können dazu beitragen. Zahlreiche Studien zeigen, dass Magnesium bei der Therapie und Prävention vieler Erkrankungen erfolgreich eingesetzt werden kann. Für einen breiteren Einsatz in der Medizin sprechen die hohe Verträglichkeit, das breite therapeutische Spektrum, die einfache Anwendung, das weitgehende Fehlen von Interaktionen mit Medikamenten, die kurze Halbwertszeit und nicht zuletzt der günstige Preis.
Vorheriger Artikel Update Zervixkarzinomscreening in der Schweiz
Nächster Artikel Lipidstoffwechsel in normgewichtigen PCOS-Patientinnen
Literatur
1.
2.
Hartwig A (2001) Role of magnesium in genomic stability. Mutat Res 475(1–2):113–121 PubMed
3.
4.
Rosanoff A, Weaver CM, Rude RK (2012) Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev 70(3):153–164 PubMed
5.
Seelig MS (1964) The requirement of magnesium by the normal adult. Am J Clin Nutr 14(6):342–390
6.
Seelig MS (1981) Magnesium requirements in human nutrition. Magnes Bull 3(Suppl 1a):26–47
7.
Graham L, Caesar J, Burger A (1960) Gastointestinal absorption and excretion of Mg 28 in man. Metabolism 9:646–659 PubMed
8.
Glei M et al (1995) Magnesium content of foodstuffs and beverages and magnesium intake of adults in Germany. Magnes Bull 17:22–28
9.
Cashman KD, Flynn A (1999) Optimal nutrition: calcium, magnesium and phosphorus. Proc Nutr Soc 58(2):477–487 PubMed
10.
Ismail Y, Ismail AA, Ismail AA (2010) The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for “normal” results. Clin Chem Lab Med 48(3):323–327 PubMed
11.
Mircetić RN et al (2001) Magnesium concentration in plasma, leukocytes and urine of children with intermittent asthma. Clin Chim Acta 312(1–2):197–203 PubMed
12.
Mauskop A et al (1993) Deficiency in serum ionized magnesium but not total magnesium in patients with migraines. Possible role of ICa2+/IMg2+ ratio. Headache 33(3):135–138 PubMed
13.
14.
Chazov EI et al (1974) Taurine and electrical activity of the heart. Circ Res 35(Suppl. 3):11–21 PubMed
15.
Bolland MJ et al (2008) Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 336(7638):262–266 PubMedPubMedCentral
16.
Bolland MJ et al (2010) Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta analysis. BMJ 341:c3691 PubMedPubMedCentral
17.
Bolland MJ et al (2011) Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Woman’s Health Initiative Limited Access Dataset and Meta-Analysis. BMJ 342:d2040 PubMedPubMedCentral
18.
Bolland MJ et al (2013) Calcium supplements and cardiovascular risk: 5 years on. Ther Adv Drug Saf 4(5):199–210 PubMedPubMedCentral
19.
Nicoll R, Howard JM, Henein MY (2015) A review of the effect of diet on cardiovascular calcification. Int J Mol Sci 16(4):8861–8883 PubMedPubMedCentral
20.
Hruby A, O’Donnell CJ, Jacques PF et al (2014) Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. Jacc Cardiovasc Imaging 7(1):59–69 PubMed
21.
Maier JA, Malpuech-Brugere C, Zimowska W et al (2004) Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis. Biochim Biophys Acta 1689(1):13–21 PubMed
22.
Labeeuw M et al (1987) Role of magnesium in the physiopathology and treatment of calcium renal lithiasis. Presse Med 16(1):25–27 PubMed
23.
Massey L (2005) Magnesium therapy for nephrolithiasis. Magnes Res 18(2):123–126 PubMed
24.
Liao F, Folsom AR, Brancati FL (1998) Is low magnesium concentration a risk factor for coronary heart disease? The atherosclerosis risk in communities (ARIC) study. Am Heart J 136(3):480–490 PubMed
25.
Ford ES (1999) Serum magnesium and ischaemic heart disease: findings from a national sample of US adults. Int J Epidemiol 28(4):645–651 PubMed
26.
Del Gobbo LC, Imamura F, Wu JH et al (2013) Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 98(1):160–173 PubMedPubMedCentral
27.
Guasch-Ferre M, Bullo M, Estruch R et al (2014) Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk. J Nutr 144(1):55–60 PubMed
28.
Yamori Y, Sagara M, Mizushima S et al (2015) An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations. Hypertens Res 38(3):219–225 PubMed
29.
Kolte D, Vijayaraghavan K, Khera S et al (2014) Role of magnesium in cardiovascular diseases. Cardiol Rev 22(4):182–192 PubMed
30.
Kisters K et al (1999) Hypomagnesaemia, borderline hypertension and hyperlipidaemia. Magnes Bull 21:31–34
31.
Resnick LM et al (2000) Factors affecting blood pressure responses to diet: the Vanguard study. Am J Hypertens 13(9):956–965 PubMed
32.
Rosanoff A, Plesset MR (2013) Oral magnesium supplements decrease high blood pressure (SBP > 155 mm Hg) in hypertensive subjects on anti-hypertensive medications: a targeted meta-analysis. Magnes Res 26(3):93–99 PubMed
33.
Singh RB et al (1991) Does dietary magnesium modulate blood lipids? Biol Trace Elem Res 30(1):59–64 PubMed
34.
Corica F et al (1994) Effects of oral magnesium supplementation on plasma lipid concentrations in patients with non-insulin-dependent diabetes mellitus. Magnes Res 7(1):43–47 PubMed
35.
Durlach J (1996) Commentary on recent epidemiological and clinical advances. Magnes Res 9(2):139–141 PubMed
36.
King DE et al (2006) Magnesium supplement intake and C‑reactive protein levels in adults. Nutr Res 26(5):193–196
37.
Shechter M et al (2001) Beneficial antithrombotic effects of the association of pharmacological oral magnesium therapy with aspirin in coronary heart disease patients. Magnes Res 13(4):275–284
38.
Parikka HJ, Toivonen LK (1999) Acute effects of intravenous magnesium on ventricular refractoriness and monophasic action potential duration in humans. Scand Cardiovasc J 33(5):300–305 PubMed
39.
Thiele R et al (2000) Effect of intravenous magnesium on ventricular tachyarrhythmias associated with acute myocardial infarction. Magnes Res 13(2):111–122 PubMed
40.
Ceremuzyński L et al (2000) Hypermagnesemia in heart failure with ventricular arrhythmias. Beneficial effects of magnesium supplementation. J Intern Med 247(1):78–86 PubMed
41.
Dyckner T, Wester PO (1984) Magnesium deficiency in congestive heart failure. Acta Pharmacol Toxicol (Copenh) 54(Suppl.s1):119–123
42.
England MR et al (1992) Magnesium administration and dysrhythmias after cardiac surgery. JAMA 268(17):2395–2402 PubMed
43.
Caspi J et al (1995) Effects of magnesium on myocardial function after coronary artery bypass grafting. Ann Thorac Surg 59(4):942–947 PubMed
44.
Toraman F et al (2001) Magnesium infusion dramatically decreases the incidence of atrial fibrillation after coronary artery bypass grafting. Ann Thorac Surg 72(4):1256–1262 PubMed
45.
Teo KK et al (1991) Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomized trials. BMJ 303(6816):1499–1503 PubMedPubMedCentral
46.
Teo KK, Yusuf S (1993) Role of magnesium in reducing mortality in acute myocardial infarction. A review of the evidence. Drugs 46(3):347–359 PubMed
47.
Woods KL et al (1992) Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 339(8809):1553–1558 PubMed
48.
Woods KL, Fletcher S (1994) Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 343(8901):816–819 PubMed
49.
ISIS-4 Collaboration Group (1995) ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate and intravenous magnesium sulphate in 58’050 patients with suspected acute myocardial infarction. Lancet 345(8951):669–682
50.
Seelig MS (1994) Cardiovascular reactions to stress intensified by magnesium deficit, in Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications: a review. J Am Coll Nutr 13(5):429–446 PubMed
51.
Chiuve SE, Korngold EC, Januzzi JL Jr. et al (2011) Plasma and dietary magnesium and risk of sudden cardiac death in women. Am J Clin Nutr 93(2):253–260 PubMed
52.
Seelig MS (1982) Prenatal and neonatal mineral deficiencies: magnesium, zinc and chromium. In: Lifshitz F (Hrsg) Clinical disorders in Pedriatic nutrition. Marcel Dekker, N.Y., S 167–196
53.
Seelig MS (1991) Magnesium in pregnancy: special needs for the adolescent mother. J Am Coll Nutr 10:566
54.
Caddel JL (2001) Magnesium deficiency promotes muscle weakness, contribution to the risk of sudden infant death (SIDS) in infants sleeping prone. Magnes Res 14(1–2):39–50
55.
56.
Sojka JE, Weaver CM (1995) Magnesium supplementation and osteoporosis. Nutr Rev 53(3):71–74 PubMed
57.
Abraham GE, Grewal HA (1990) A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med 35(5):503–507 PubMed
58.
Seelig MS (1990) Increased magnesium need with use of combined oestrogen and calcium for osteoporosis treatment. Magnes Res 3(3):197–215 PubMed
59.
Orchard TS, Larson JC, Alghothani N et al (2014) Magnesium intake, bone mineral density, and fractures: results from the Women’s Health Initiative Observational Study. Am J Clin Nutr 99(4):926–933 PubMedPubMedCentral
60.
Humphries S et al (1999) Low dietary magnesium is associated with insulin resistance in a sample of young, non-diabetic Black Americans. Am J Hypertens 12(8):747–756 PubMed
61.
Alzaid AA et al (1995) Effects of insulin on plasma magnesium in noninsulin-dependent diabetes mellitus: evidence for insulin resistance. J Clin Endocrinol Metab 80(4):1376–1381 PubMed
62.
Guerrero-Romero F, Tamez-Perez HE, Gonzalez-Gonzalez G et al (2004) Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab 30(3):253–258 PubMed
63.
Simental-Mendia LE, Sahebkar A, Rodriguez-Moran M et al (2016) A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Pharmacol Res 111:272–282 PubMed
64.
de Lourdes Lima M et al (1998) The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care 21(5):682–686
65.
Engelen W et al (2000) Are low magnesium levels in type 1 diabetes associated with electromyographical signs of polyneuropathy? Magnes Res 13(3):197–203 PubMed
66.
Ma E et al (2010) High dietary intake of magnesium may decrease risk of colorectal cancer in Japanese men. J Nutr 140(4):779–785 PubMed
67.
Wark PA, Lau R, Norat T et al (2012) Magnesium intake and colorectal tumor risk: a case-control study and meta-analysis. Am J Clin Nutr 96(3):622–631 PubMed
68.
Dibaba D, Xun P, Yokota K et al (2015) Magnesium intake and incidence of pancreatic cancer: the VITamins and Lifestyle study. Br J Cancer 113(11):1615–1621 PubMedPubMedCentral
69.
Huxley R, Ansary-Moghaddam A, Berrington de Gonzalez A et al (2005) Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer 92(11):2076–2083 PubMedPubMedCentral
70.
Ben Q, Xu M, Ning X et al (2011) Diabetes mellitus and risk of pancreatic cancer: A meta-analysis of cohort studies. Eur J Cancer 47(13):1928–1937 PubMed
71.
Chari ST, Leibson CL, Rabe KG et al (2008) Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer. Gastroenterology 134(1):95–101 PubMed
72.
Song S, Wang B, Zhang X et al (2015) Long-term diabetes mellitus is associated with an increased risk of pancreatic cancer: a Meta-analysis. PLoS ONE 10(7):e134321 PubMedPubMedCentral
73.
Batabyal P, Vander Hoorn S, Christophi C et al (2014) Association of diabetes mellitus and pancreatic adenocarcinoma: a meta-analysis of 88 studies. Ann Surg Oncol 21(7):2453–2462 PubMed
74.
Stolzenberg-Solomon RZ, Graubard BI, Chari S et al (2005) Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers. JAMA 294(22):2872–2878 PubMed
75.
Wolpin BM, Bao Y, Qian ZR et al (2013) Hyperglycemia, insulin resistance, impaired pancreatic beta-cell function, and risk of pancreatic cancer. J Natl Cancer Inst 105(14):1027–1035 PubMedPubMedCentral
76.
Evans JM, Donnelly LA, Emslie-Smith AM et al (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ 330(7503):1304–1305 PubMedPubMedCentral
77.
Lee MS, Hsu CC, Wahlqvist ML et al (2011) Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer 11:20 PubMedPubMedCentral
78.
Wang LW, Li ZS, Zou DW et al (2008) Metformin induces apoptosis of pancreatic cancer cells. World J Gastroenterol 14(47):7192–7198 PubMedPubMedCentral
79.
Sherwood RA et al (1986) Magnesium and the premenstrual syndrome. Ann Clin Biochem 23(6):667–670 PubMed
80.
Posaci C et al (1994) Plasma copper, zinc and magnesium levels in patients with premenstrual tension syndrome. Acta Obstet Gynecol Scand 73(6):452–455 PubMed
81.
Muneyvirci-Delale O et al (1998) Sex steroid hormones modulate serum ionized magnesium and calcium levels throughout the menstrual cycle in women. Fertil Steril 69(5):958–962 PubMed
82.
Werbach M (1995) Premenstrual syndrome: magnesium. Townsend Lett Dr 13:26
83.
Facchinetti F et al (1991) Oral magnesium successfully relieves premenstrual mood changes. Obstet Gynecol Clin North Am 78(2):177–181
84.
Benassi L et al (1992) Effectiveness of magnesium pidolate in the prophylactic treatment of primary dysmenorrhea. Clin Exp Obstet Gynecol 19(3):176–179 PubMed
85.
Fontana-Klaiber H, Hogg B (1990) Therapeutische Wirkung von Magnesium bei Dysmenorroe. Schweiz Rundsch Med Prax 79(16):491–494 PubMed
86.
Seifert B et al (1989) Magnesium – a new therapeutic alternative in primary dysmenorrhea. Zentralbl Gynakol 111(11):755–760 PubMed
87.
Goldberg B (1998) Alternative medicine guide: women’s health series 1. Future Medicine Publishing, Tiburon
88.
Edorh AP et al (2003) Magnesium content in seminal fluid as an indicator of chronic prostatitis. Cell Mol Biol 49:419–423
89.
Seelig MS (1994) Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications: a review. J Am Coll Nutr 13(5):429–446. www.​mgwater.​com PubMed
90.
Conradt A, Weidinger AH (1982) The central position of magnesium in the management of fetal hypotrophy—a contribution to the pathomechanism of utero-placental insufficiency, prematurity and poor intrauterine fetal growth as well as pre-eclampsia. Magnes Bull 4:103–124
91.
Handwerker SM et al (1993) Ionized serum magnesium levels in umbilical cord blood of normal pregnant women at delivery: relationship to calcium, demographics and birthweight. Am J Perinatol 10(5):392–397 PubMed
92.
Handwerker SM, Altura BT, Altura BM (1996) Serum ionized magnesium and other electrolytes in the antenatal period of human pregnancy. J Am Coll Nutr 15(1):36–43 PubMed
93.
Almonte RA et al (1999) Gestational magnesium deficiency is deleterious to fetal outcome. Biol Neonate 76(1):26–32 PubMed
94.
Peikert A, Wilimzig C, Köhne-Volland R (1996) Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalagia 16(4):257–263
95.
Chiu HY, Yeh TH, Huang YC et al (2016) Effects of intravenous and oral magnesium on reducing migraine: a Meta-analysis of randomized controlled trials. Pain Physician 19(1):E97–E112 PubMed
96.
Mauskop A, Varughese J (2012) Why all migraine patients should be treated with magnesium. J Neural Transm (vienna) 119(5):575–579
97.
Talebi M, Savadi-Oskouei D, Farhoudi M et al (2011) Relation between serum magnesium level and migraine attacks. Neurosciences (Riyadh) 16(4):320–323
98.
Charles AC, Baca SM (2013) Cortical spreading depression and migraine. Nat Rev Neurol 9(11):637–644 PubMed
99.
Sun-Edelstein C, Mauskop A (2009) Role of magnesium in the pathogenesis and treatment of migraine. Expert Rev Neurother 9(3):369–379 PubMed
100.
Mauskop A et al (1995) Intravenous magnesium sulfate relieves cluster headache in patients with low serum ionized magnesium levels. Headache 35(10):597–600 PubMed
101.
Werbach MR (1995) Nutritional influences on aggressive behavior. J Orthomol Med 7(1):45–51
102.
Cox RH, Shealy CN et al (1996) Significant magnesium deficiency in depression. J Neur Orth Med Surg 17:7–9
103.
Seelig MS (1998) Review and hypothesis: might patients with the chronic fatigue syndrome have latent tetany of magnesium deficiency. J Chronic Fatigue Syndr 4(2):77–108
104.
Cox IM et al (1991) Red blood cell magnesium and chronic fatigue syndrome. Lancet 337(8744):757–760 PubMed
105.
Vink R, Nechifor M (2011) Magnesium in the central nervous system. University of Adelaide Press, Adelaide
106.
Gröber U, Kisters K (2017) Arzneimittel als Mikronährstoffräuber, 2. Aufl. Wissenschaftliche Verlagsgesellschaft, Stuttgart
107.
Andersen G (2011) Lebensmitteltabelle für die Praxis, 5. Aufl. Der kleine Souci/Fachmann/Kraut. Wissenschaftliche Verlagsgesellschaft, Stuttgart
Metadaten
Titel
Magnesium – das unterschätzte Mineral
Rolle von Magnesium im Stoffwechsel und praktische Empfehlungen
verfasst von
Dr. Roland Stegmann
Publikationsdatum
05.06.2019
Verlag
Springer Vienna
Erschienen in
Journal für Gynäkologische Endokrinologie/Schweiz / Ausgabe 2/2019
Print ISSN: 1995-6924
Elektronische ISSN: 2520-8500
DOI
https://doi.org/10.1007/s41975-019-0092-2

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