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Erschienen in: Wiener klinische Wochenschrift 9-10/2023

24.04.2023 | original article

Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients

A single center registry-based retrospective cohort study

verfasst von: Grgur Salai, Hrvoje Vrazic, Ivona Kovacevic, Linda Malnar Janes, Ivan Marasovic, Darjan Ranilovic, Damir Vukoja, Marina Zelenika Margeta, Ivana Huljev–Sipos, Kristina Lalic, Marko Spoljaric, Jasna Tekavec-Trkanjec, Mirna Vergles, Marko Lucijanic, Ivica Luksic, Divo Ljubicic

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2023

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Summary

Introduction

The impact of asthma and chronic obstructive pulmonary disease (COPD) in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2) infection is not clearly defined. Blood eosinophil count is a standard diagnostic test which, according to the previously published literature, might have a potential prognostic role on mortality in patients with SARS-CoV‑2 infection.

Aim

To investigate the potential prognostic value of peripheral blood eosinophil count on all-cause mortality of patients hospitalized with SARS-CoV‑2 infection, as well as to assess the impact of asthma or COPD premorbidity on all-cause mortality.

Material and methods

We conducted a retrospective registry-based cohort study. Survival analysis was performed by employing the Cox proportional hazards regression model at 30 days of follow-up. Prognostic value of eosinophil count on all-cause mortality was assessed using receiver-operating characteristic (ROC) curve analysis.

Results

A total of 5653 participants were included in the study. Our model did not reveal that pre-existing asthma or COPD is a statistically significant covariate for all-cause mortality but, indicated that higher eosinophil count at admission might have a protective effect (hazard ratio, HR 0.13 (95% confidence interval, CI 0.06–0.27), p = 0.0001). ROC curve analysis indicates cut-off value of 20 cells/mm3 (81% specificity; 30.9% sensitivity).

Conclusion

Our results indicate that eosinophil count at hospital admission might have a potential prognostic role for all-cause mortality at 30 days of follow-up; however this was not demonstrated for pre-existing obstructive lung diseases.
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Metadaten
Titel
Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients
A single center registry-based retrospective cohort study
verfasst von
Grgur Salai
Hrvoje Vrazic
Ivona Kovacevic
Linda Malnar Janes
Ivan Marasovic
Darjan Ranilovic
Damir Vukoja
Marina Zelenika Margeta
Ivana Huljev–Sipos
Kristina Lalic
Marko Spoljaric
Jasna Tekavec-Trkanjec
Mirna Vergles
Marko Lucijanic
Ivica Luksic
Divo Ljubicic
Publikationsdatum
24.04.2023
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 9-10/2023
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-023-02180-w

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