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01.08.2017 | original article | Ausgabe 4/2017

European Surgery 4/2017

Effects of papaverine on healing of colonic anastomosis in rats

European Surgery > Ausgabe 4/2017
MD Salim Ilksen Basceken, MD, FTBS Yusuf Sevim, MD Cihangir Akyol, MD Egemen Cicek, MD Ferit Aydın, MD Akin Firat Kocaay, PhD Ozge Tugce Pasaoglu, MD Volkan Genc, PhD Hatice Pasaoglu, MD Atil Cakmak
Wichtige Hinweise
Conception and design of the study: Salim Ilksen Basceken, Atil Cakmak, Volkan Genc.
Acquisition of data, or analysis and interpretation of data: Salim Ilksen Basceken, Yusuf Sevim, Akin Firat Kocaay, Ozge Tugce Pasaoglu, Hatice Pasaoglu.
Drafting the article or revising it critically for important intellectual content: Yusuf Sevim, Cihangir Akyol, Egemen Cicek, Ferit Aydin.
Final approval of the version to be submitted: Atil Cakmak, Cihangir Akyol, Volkan Genc.



Anastomotic leak is the most devastating complication after colorectal surgery, and the blood supply is a very important factor in anastomotic healing. Papaverine is a vasodilatory and antispasmodic agent which has been used in many ischemic conditions because of its potentially protective effects. The aim of this study is to investigate the effects of papaverine on healing colon anastomosis.


Forty 8‑ to 10-week-old female Wistar Albino rats were used in this study. Rats were randomized into 4 groups: control group; ischemia-reperfusion and anastomosis group; ischemia-reperfusion and anastomosis + intraperitoneal one dose papaverine group; and ischemia-reperfusion and anastomosis + intraperitoneal daily (10 days) papaverine group. Anastomotic bursting pressures, the hydroxyproline measurements and macroscopic adhesion gradings were evaluated.


There was a significant difference between papaverine-administered groups and ischemia-reperfusion and anastomosis group for anastomotic bursting pressures, hydroxyproline measurements and macroscopic adhesion grading (p < 0.05).


In the rat model, papaverine had a favorable effect on anastomotic healing.

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