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European Surgery
Erschienen in:

01.08.2017 | original article

Effects of papaverine on healing of colonic anastomosis in rats

verfasst von: Salim Ilksen Basceken, MD, Yusuf Sevim, MD, FTBS, Cihangir Akyol, MD, Egemen Cicek, MD, Ferit Aydın, MD, Akin Firat Kocaay, MD, Ozge Tugce Pasaoglu, PhD, Volkan Genc, MD, Hatice Pasaoglu, PhD, Atil Cakmak, MD

Erschienen in: European Surgery | Ausgabe 4/2017

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Summary

Background

Anastomotic leak is the most devastating complication after colorectal surgery, and the blood supply is a very important factor in anastomotic healing. Papaverine is a vasodilatory and antispasmodic agent which has been used in many ischemic conditions because of its potentially protective effects. The aim of this study is to investigate the effects of papaverine on healing colon anastomosis.

Methods

Forty 8‑ to 10-week-old female Wistar Albino rats were used in this study. Rats were randomized into 4 groups: control group; ischemia-reperfusion and anastomosis group; ischemia-reperfusion and anastomosis + intraperitoneal one dose papaverine group; and ischemia-reperfusion and anastomosis + intraperitoneal daily (10 days) papaverine group. Anastomotic bursting pressures, the hydroxyproline measurements and macroscopic adhesion gradings were evaluated.

Results

There was a significant difference between papaverine-administered groups and ischemia-reperfusion and anastomosis group for anastomotic bursting pressures, hydroxyproline measurements and macroscopic adhesion grading (p < 0.05).

Conclusion

In the rat model, papaverine had a favorable effect on anastomotic healing.
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Metadaten
Titel
Effects of papaverine on healing of colonic anastomosis in rats
verfasst von
Salim Ilksen Basceken, MD
Yusuf Sevim, MD, FTBS
Cihangir Akyol, MD
Egemen Cicek, MD
Ferit Aydın, MD
Akin Firat Kocaay, MD
Ozge Tugce Pasaoglu, PhD
Volkan Genc, MD
Hatice Pasaoglu, PhD
Atil Cakmak, MD
Publikationsdatum
01.08.2017
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 4/2017
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-017-0481-1

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